Výzkumné instituce sdružené v NÚVR se mj. zavázaly k tomu, že vytvoří více než 600 klasifikovatelných výstupů, z toho přes 400 odborných publikací. Zde najdete přehled prací zveřejněných v odborných časopisech spadajících do prvního kvartilu daného oboru a některé další výstupy projektu.
Mitochondrial Transfer Rescues Respiration to Support De Novo Pyrimidine Biosynthesis and Tumor Progression. Dubisova Maria, Bohacova Klara, Nahacka Zuzana, Kraus Daniel, Novak Jaromir, Dvorakova Sarka, Brisudova Petra, Danesova Natalie, Selvi Saba, Hrysiuk Mariia, Endaya Berwini B., Botsios Panagiotis, Le Dan-Diem Thi, Novotna Monika, Vodenkova Sona, Truksa Jaroslav, Chalupsky Karel, Klima Krystof, Prochazka Jan, Sedlacek Radislav, Mengarelli Francesco, Orlando Patrick, Tiano Luca, Boukalova Stepana, Berridge Michael V., Zobalova Renata a Neuzil Jiri. Cancer Research [online], 2026, 86(4), 925-939.
doi: https://doi.org/10.1158/0008-5472.CAN-24-0737. PMID: 41248423
Cell Invasion Analysis of Tumor Spheroids Using 2D Image Data. Přikryl Matěj, Rousová Andrea, Acimovic Ivana, Vaňhara Petr, Jan Lukáš, Beneš Petr, Šmarda Jan, Kozubek Michal, Štěpka Karel a Navrátilová Jarmila. ACS Measurement Science Au [online], 2026, 6(1), 59-67.
doi: https://doi.org/10.1021/acsmeasuresciau.5c00121. PMID: 41727361
Hydrophobic residues in the α‐synuclein NAC domain drive seed‐competent fibril formation and are targeted by peptide inhibitors. Das Viswanath, Modarres Mousavi Sayed Mostafa, Annadurai Narendran, Sukur Sunčica, Mehrnejad Faramarz, Moradi Sajad, Malina Lukáš, Kolaříková Markéta, Ranc Vaclav, Frydrych Ivo, Kouřil Roman, Hosseinkhani Saman, Hajdúch Marián a Nikkhah Maryam. The FEBS Journal [online], 2026, 293(1.0), 134-155.
doi: https://doi.org/10.1111/febs.70222. PMID: 40819250
Novel dimeric dual-modality FAP-targeted agents with favorable tumor retention for image-guided surgery: a preclinical study. Gariglio Giacomo, Hasenöhrl Thomas, Bendova Katerina, Nový Zbyněk, Rangger Christine, Kummer Kai, Smith Bradley D., Matuszczak Barbara, Petrik Milos a Decristoforo Clemens. European Journal of Nuclear Medicine and Molecular Imaging [online], 2026, 53(4.0), 2578-2591.
doi: https://doi.org/10.1007/s00259-025-07626-z. PMID: 41258458
Potent Competitive Inhibitors of Ecto-5′-nucleotidase (CD73) based on 6-(Het)aryl-7-deazapurine Ribonucleoside 5′-O-Bisphosphonates. Šinkevičiu̅tė Ugnė, Šímová Magdalena, Staník Radek, Poštová Slavětínská Lenka, Blažková Kristýna, Šácha Pavel, Lepšík Martin, Řezáč Jan, Konvalinka Jan, Ormsby Tereza, Tichý Michal a Hocek Michal. ACS Pharmacology & Translational Science [online], 2026, 9(1.0), 191-213.
doi: https://doi.org/10.1021/acsptsci.5c00707. PMID: 41536280
The potential of cytochalasins and other cytochalasans as drugs targeting cancer cell invasiveness and metastasis. Brož Alexandr, Volfová Tereza, Javorská Žaneta, Rösel Daniel, Brábek Jan a Perlíková Pavla. European Journal of Medicinal Chemistry [online], 2026, 304, 118502.
doi: https://doi.org/10.1016/j.ejmech.2025.118502. PMID: 41422718
Boosting CAR T-cell efficacy by blocking proteasomal degradation of membrane antigens. Rieger Leonie, Irlinger Kilian, Füchsl Franziska, Tietje Marlene, Purcarea Anna, Barbian Nicolas, Faber Melanie, Vogelsang Carolin, Pfeuffer Lisa, Stotz Sonja, Karpiuk Oleksandra, Schulze Tobias, Augsburger Abirami, Glaisner Nadine, Konetzki Verena, Friedel Sabrina, Besse Andrej, Besse Lenka, Driessen Christoph, Buchner Maike, Schwamborn Kristina, Steiger Katja, Giansanti Piero, Theurich Sebastian, Waldschmidt Johannes, Kortüm K. Martin, Hudecek Michael, Einsele Hermann, Högner Marion, Kuster Bernhard, Krackhardt Angela M., Hecker Judith S. a Bassermann Florian. Blood [online], 2026, 147(5), 534-546.
doi: https://doi.org/10.1182/blood.2024027616. PMID: 40638685
Front-illuminated surface plasmon resonance biosensor for the study of light-responsive proteins and their interactions. Finocchiaro Giusy, Chaudhari Aditya Suresh, Špringer Tomáš, Králová Kateřina, Chadt Karel, Hemmerová Erika, Bukáček Jan, Pham Phuong Ngoc, Chatterjee Aditi, Schneider Bohdan, Fuertes Gustavo a Homola Jiří. Biosensors and Bioelectronics [online], 2026, 291, 117998.
doi: https://doi.org/10.1016/j.bios.2025.117998. PMID: 41014988
2025
SMARCA4-deficient dedifferentiated ovarian carcinoma with rapid progression during adjuvant platinum-based chemotherapy: a case report and implications for molecular-driven treatment strategies. Bednaříková Markéta, Hausnerová Jitka, Pokorná Petra, Felsinger Michal, Richter Svatopluk, Ehrlichová Lucie, Orlíčková Jana, Minář Luboš, Slabý Ondřej a Weinberger Vít. Therapeutic Advances in Medical Oncology [online], 2025, 17, 17588359251376858.
doi: https://doi.org/10.1177/17588359251376858. PMID: 41142476
Endoplasmic reticulum stress disrupts signaling via altered processing of transmembrane receptors. Bosakova Michaela, Abraham Sara P., Wachtell Davis, Zieba Jennifer T., Kot Alexander, Nita Alexandru, Czyrek Aleksandra Anna, Koudelka Adolf, Ursachi Vlad-Constantin, Feketova Zuzana, Rico-Llanos Gustavo, Svozilova Katerina, Kocerova Petra, Fafilek Bohumil, Gregor Tomas, Kotaskova Jana, Duran Ivan, Vanhara Petr, Doubek Michael, Mayer Jiri, Soucek Karel, Krakow Deborah a Krejci Pavel. Cell Communication and Signaling [online], 2025, 23(1), 209.
doi: https://doi.org/10.1186/s12964-025-02208-w. PMID: 40307870
Detection of early relapse in multiple myeloma patients. Růžičková Tereza, Vlachová Monika, Pečinka Lukáš, Brychtová Monika, Večeřa Marek, Radová Lenka, Ševčíková Simona, Jarošová Marie, Havel Josef, Pour Luděk a Ševčíková Sabina. Cell Division [online], 2025, 20(1), 4.
doi: https://doi.org/10.1186/s13008-025-00143-3. PMID: 39881385
Depleting chemoresponsive mitochondrial fission mediator DRP1 does not mitigate sarcoma resistance. Borankova Karolina, Solny Matyas, Krchniakova Maria a Skoda Jan. Life Science Alliance [online], 2025, 8(2), e202402870.
doi: https://doi.org/10.26508/lsa.202402870. PMID: 39643272
Association of the combined parameters including the frequency of primary cilia, PD-L1, Smoothened protein, membranous β-catenin and cytoplasmic β-catenin expression with the outcome of patients with clear cell renal cell carcinoma. Rozsypalova Aneta, Rosova Blanka, Filipova Alzbeta, Nikolov Dimitar Hadzi, Chloupkova Renata, Richter Igor, Zachoval Roman, Matej Radoslav, Melichar Bohuslav, Buchler Tomas a Dvorak Josef. Biomedical Papers [online], 2025, 169(2), 107-115.
doi: https://doi.org/10.5507/bp.2024.005. PMID: 38420990
Multiple polygenic score approach in colorectal cancer risk prediction. Jiang Shangqing Joyce, Thomas Minta, Rosenthal Elisabeth A., Phipps Amanda I., Sakoda Lori C., Van Duijnhoven Franzel J. B., Pellatt Andrew J., Avery Christy L., Berndt Sonja I., Bishop D. Timothy, Castellví-Bel Sergi, Chan Andrew T., Grant Robert C., Gignoux Chris, Gsur Andrea, Gunter Marc J., Haiman Christopher A., Hoffmeister Michael, Jarvik Gail P., Jenkins Mark A., Keku Temitope O., Küry Sébastien, Lee Jeffrey K., Marchand Loic Le, Moreno Victor, Newcomb Polly A., Newton Christina C., Ogino Shuji, Palmer Julie R., Pearlman Rachel, Qu Conghui, Schoen Robert E., Um Caroline Y., Van Guelpen Bethany, Visvanathan Kala, Vymetalkova Veronika, White Emily, Woods Michael O., Platz Elizabeth A., Brenner Hermann, Corley Douglas A., Vogelaar Iris Landorp, Hsu Li a Peters Ulrike. Scientific Reports [online], 2025, 15(1), 38006.
doi: https://doi.org/10.1038/s41598-025-21956-w. PMID: 41168411
Transcriptome-wide Mendelian randomization exploring dynamic CD4+ T cell gene expression in colorectal cancer development. Deslandes Benedita, Wu Xueyan, Lee Matthew A, Goudswaard Lucy J, Jones Gareth W, Gsur Andrea, Lindblom Annika, Ogino Shuji, Vymetalkova Veronika, Wolk Alicja, Wu Anna H, Huyghe Jeroen R, Peters Ulrike, Phipps Amanda I, Thomas Claire E, Pai Rish K, Grant Robert C, Buchanan Daniel D, Yarmolinsky James, Gunter Marc J, Zheng Jie, Hazelwood Emma a Vincent Emma E. Journal of Leukocyte Biology [online], 2025, 117(10), qiaf131.
doi: https://doi.org/10.1093/jleuko/qiaf131. PMID: 40974097
Plasma miR-122-5p and miR-142-5p and their role in chemoresistance of patients with colon cancer. Vokacova Klara, Landecka Aneta, Selvi Saba, Horak Josef, Novosadova Vendula, Manakova Katerina, Levy Miroslav a Vymetalkova Veronika. Mutagenesis [online], 2025, 40(1), 80-86.
doi: https://doi.org/10.1093/mutage/geae023. PMID: 39275807
Defective DNA repair: a putative nexus linking immunological diseases, neurodegenerative disorders, and cancer. Andarawi Safaa, Vodickova Ludmila, Uttarilli Anusha, Hanak Petr a Vodicka Pavel. Mutagenesis [online], 2025, 40(1), 4-19.
doi: https://doi.org/10.1093/mutage/geae029. PMID: 39937585
Novel approaches for the discovery of pharmacogenetic biomarkers of chemotoxicity in patients with colorectal cancer. Simoes Ana Rita, Carlés González Silvia, Lopez‐Doldan María Del Carmen, Duran Goretti, Fernández‐Montes Ana, Fernandez Maria Perfecta, Salgado Fernandez Mercedes, Garcia Mata Jesus, Paez David, Riera Pau, Guino Elisabeth, Lopez‐Fernandez Luis, Garcia De Santiago Belen, López Aspiroz Elena, Rojas Augusto, Castells Antoni, Castellvi‐Bel Sergi, Ruiz Ponte Clara, Vymetalkova Veronika, Carracedo Angel a Fernandez‐Rozadilla Ceres. British Journal of Pharmacology [online], 2025, 182(21), 5340-5354.
doi: https://doi.org/10.1111/bph.70051. PMID: 40624839
Biomimetic Tumour Model Systems for Pancreatic Ductal Adenocarcinoma in Relation to Photodynamic Therapy. Smith Olivia M., Lintern Nicole, Tian Jiahao, Mesquita Bárbara M., Oliveira Sabrina, Vymetalkova Veronika, Prakash Jai, Smith Andrew M., Jayne David G., Heger Michal a Khaled Yazan S.. International Journal of Molecular Sciences [online], 2025, 26(13), 6388.
doi: https://doi.org/10.3390/ijms26136388. PMID: 40650165
Surface plasmon resonance biosensors and their medical applications. Špringer Tomáš, Bocková Markéta, Slabý Jiří, Sohrabi Foozieh, Čapková Magdalena a Homola Jiří. Biosensors and Bioelectronics [online], 2025, 278, 117308.
doi: https://doi.org/10.1016/j.bios.2025.117308. PMID: 40037036
Extracellular vesicles in cancer´s communication: messages we can read and how to answer. Semeradtova Alena, Liegertova Michaela, Herma Regina, Capkova Magdalena, Brignole Chiara a Del Zotto Genny. Molecular Cancer [online], 2025, 24(1), 86.
doi: https://doi.org/10.1186/s12943-025-02282-1. PMID: 40108630
Negative prognostic significance of primary cilia and cytoplasmic β-catenin expression in non-small cell lung cancer. Rosova Blanka, Filipova Alzbeta, Nikolov Dimitar Hadzi, Drösslerova Marie, Matej Radoslav, Rozsypalova Aneta, Richter Igor, Melichar Bohuslav, Mahel Rostislav, Stepanova Radka, Lohynska Radka a Dvorak Josef. Neoplasma [online], 2025, 71(06), 594-602.
doi: https://doi.org/10.4149/neo_2024_241117N476. PMID: 39832204
Exome sequencing identifies HELB as a novel susceptibility gene for non-mucinous, non-high-grade-serous epithelial ovarian cancer. Dicks Ed M., Tyrer Jonthan P., Ezquina Suzana, Jones Michelle, Baierl John, Peng Pei-Chen, Diaz Michael, Goode Ellen, Winham Stacey J., Dörk Thilo, Gorp Toon Van, Fazio Anna De, Bowtell David D. L., Garsed Dale W., Odunsi Kunle, Moysich Kirsten, Pavanello Marina, Fostira Florentia, Webb Penelope M., Soukupová Jana, Cohen Paul A., Sieh Weiva, Fortner Renée Turzanski, Ricker Charite, Karlan Beth, Campbell Ian, Brenton James D., Ramus Susan J., Gayther Simon A. a Pharoah Paul D. P.. European Journal of Human Genetics [online], 2025, 33(3), 297-303.
doi: https://doi.org/10.1038/s41431-025-01786-0. PMID: 39939714
Case-Control Study for 23 Cancer Types With Functional Analysis of CHEK2: Risk Estimation and Clinical Recommendations in East Asia. Takehara Yuri, Usui Yoshiaki, Stolařová Lenka, Kleiblova Petra, Iwasaki Yusuke, Johnson Todd A., Hirata Makoto, Kamatani Yoichiro, Murakami Yoshinori, Endo Mikiko, Shiraishi Kouya, Kohno Takashi, Sugano Kokichi, Matsuda Koichi, Yoshida Teruhiko, Spurdle Amanda B., Nakagawa Hidewaki, Macurek Libor, Kleibl Zdenek a Momozawa Yukihide. JCO Precision Oncology [online], 2025, e2400945.
doi: https://doi.org/10.1200/PO-24-00945. PMID: 40893051
A retrospective single-center pilot study of the genetic background of the transplanted kidney. Novotna Anna, Horackova Klara, Soukupova Jana, Zemankova Petra, Nehasil Petr, Just Pavel, Voska Ludek, Kleiblova Petra a Rajnochova Bloudickova Silvie. PLOS ONE [online], 2025, 20(1), e0316192.
doi: https://doi.org/10.1371/journal.pone.0316192. PMID: 39777909
B-Cell Receptor Signaling and Beyond: The Role of Igα (CD79a)/Igβ (CD79b) in Normal and Malignant B Cells. Tkachenko Anton, Kupcova Kristyna a Havranek Ondrej. International Journal of Molecular Sciences [online], 2023, 25(1), 10.
doi: https://doi.org/10.3390/ijms25010010. PMID: 38203179
Assessing regulated cell death modalities as an efficient tool for in vitro nanotoxicity screening: a review. Tkachenko Anton, Onishchenko Anatolii, Myasoedov Valeriy, Yefimova Svetlana a Havranek Ondrej. Nanotoxicology [online], 2023, 17(3), 218-248.
doi: https://doi.org/10.1080/17435390.2023.2203239. PMID: 37083543
Redox Status of Erythrocytes as an Important Factor in Eryptosis and Erythronecroptosis. Tkachenko Anton a Havránek Ondřej. Folia Biologica [online], 2023, 69(4), 116-126.
doi: https://doi.org/10.14712/fb2023069040116. PMID: 38410969
Cell death signaling in human erythron: erythrocytes lose the complexity of cell death machinery upon maturation. Tkachenko Anton a Havranek Ondrej. Apoptosis [online], 2025, 30(3-4), 652-673.
doi: https://doi.org/10.1007/s10495-025-02081-5. PMID: 39924584
Targeting FMS-like tyrosine kinase 3 (FLT3) in acute myeloid leukemia: Novel molecular approaches and therapeutic challenges. Rataj Jan, Gorecki Lukas, Muthna Darina, Sorf Ales, Krystof Vladimir, Klener Pavel, Ceckova Martina, Rezacova Martina a Korabecny Jan. Biomedicine & Pharmacotherapy [online], 2025, 182, 117788.
doi: https://doi.org/10.1016/j.biopha.2024.117788. PMID: 39733588
Current understanding of eryptosis: mechanisms, physiological functions, role in disease, pharmacological applications, and nomenclature recommendations. Tkachenko Anton, Alfhili Mohammad A., Alsughayyir Jawaher, Attanzio Alessandro, Al Mamun Bhuyan Abdulla, Bukowska Bożena, Cilla Antonio, Quintanar-Escorza Martha A., Föller Michael, Havranek Ondrej, Jilani Kashif, Onishchenko Anatolii, Pretorius Etheresia, Prokopiuk Volodymyr, Restivo Ignazio, Tesoriere Luisa, Virzì Grazia Maria a Wieder Thomas. Cell Death & Disease [online], 2025, 16(1), 467.
doi: https://doi.org/10.1038/s41419-025-07784-w. PMID: 40592821
Long-term adaptation of lymphoma cell lines to hypoxia is mediated by diverse molecular mechanisms that are targetable with specific inhibitors. Daumova Lenka, Manakov Dmitry, Petrak Jiri, Sovilj Dana, Behounek Matej, Andera Ladislav, Vit Ondrej, Souckova Olga, Havranek Ondrej, Dolnikova Alex, Renesova Nicol, Tuskova Liliana, Winkowska Lucie, Bettazova Nardjas, Kupcova Kristyna, Kalbacova Marie Hubalek, Sikorova Miriama, Trneny Marek a Klener Pavel. Cell Death Discovery [online], 2025, 11(1), 65.
doi: https://doi.org/10.1038/s41420-025-02341-y. PMID: 39966387
Circulating tumor DNA as a powerful tool in diagnostics and treatment outcome prediction – focus on large B–cell lymphomas and follicular lymphomas. Hamova Iva, Maco Maria, Tkachenko Anton, Kupcova Kristyna, Velasova Adriana, Trneny Marek, Mocikova Heidi a Havranek Ondrej. Expert Review of Molecular Diagnostics [online], 2025, 25(6), 275-295.
doi: https://doi.org/10.1080/14737159.2025.2500659. PMID: 40326242
Circulating tumour DNA as a predictor of survival of patients with diffuse large B-cell lymphoma in a daily practice. Vodicka Prokop, Hamova Iva, Velasova Adriana, Kupcova Kristyna, Zemankova Petra, Nehasil Petr, Tkachenko Anton, Lochovska Katerina, Muzikova Sarka, Hrabetova Sarka, Dlouha Jitka, Blahovcova Petra, Frouz Tomas, Senavova Jana, Dlouha Lucie, Polgarova Kamila, Klanova Magdalena, Salkova Jana, Benesova Katerina, Klener Pavel, Trneny Marek a Havranek Ondrej. British Journal of Haematology [online], 2025, 207(5), 2135-2139.
doi: https://doi.org/10.1111/bjh.70128. PMID: 40916568
Mn3O4 Nanocrystal-Induced Eryptosis Features Ca2+ Overload, ROS and RNS Accumulation, Calpain Activation, Recruitment of Caspases, and Changes in the Lipid Order of Cell Membranes. Kot Yuriy, Prokopiuk Volodymyr, Klochkov Vladimir, Tryfonyuk Liliya, Maksimchuk Pavel, Aslanov Andrey, Kot Kateryna, Avrunin Oleg, Demchenko Lesya, Kurmangaliyeva Saulesh, Onishchenko Anatolii, Yefimova Svetlana, Havranek Ondrej a Tkachenko Anton. International Journal of Molecular Sciences [online], 2025, 26(7), 3284.
doi: https://doi.org/10.3390/ijms26073284. PMID: 40244142
Autotaxin and Lysophosphatidic Acid Signalling: the Pleiotropic Regulatory Network in Cancer. Vít Ondřej a Petrák Jiří. Folia Biologica [online], 2023, 69(5-6), 149-162.
doi: https://doi.org/10.14712/fb2023069050149. PMID: 38583176
Chromatin Remodeling Enzyme Snf2h Is Essential for Retinal Cell Proliferation and Photoreceptor Maintenance. Kuzelova Andrea, Dupacova Naoko, Antosova Barbora, Sunny Sweetu Susan, Kozmik Zbynek, Paces Jan, Skoultchi Arthur I., Stopka Tomas a Kozmik Zbynek. Cells [online], 2023, 12(7), 1035.
doi: https://doi.org/10.3390/cells12071035. PMID: 37048108
Biomarkers of RV Dysfunction in HFrEF Identified by Direct Tissue Proteomics: Extracellular Proteins Fibromodulin and Fibulin-5. Běhounek Matěj, Lipcseyová Denisa, Vít Ondřej, Žáček Petr, Talacko Pavel, Husková Zuzana, Kikerlová Soňa, Tykvartová Tereza, Wohlfahrt Peter, Melenovský Vojtěch, Beneš Jan a Petrák Jiří. Circulation: Heart Failure [online], 2025, 18(3).
doi: https://doi.org/10.1161/CIRCHEARTFAILURE.124.011984. PMID: 39823288
Investigating resistance to 5-Azacytidine and Venetoclax in PDX models of MDS/AML. Bašová Petra, Minařík Lubomír, Magalhaes-Novais Silvia Carina, Balounová Jana, Zemanová Zuzana, Aghová Tatiana, Špaček Martin, Jonášová Anna, Pimková Kristýna Gloc, Procházka Jan, Sedláček Radislav a Stopka Tomáš. Frontiers in Oncology [online], 2025, 14, 1414950.
doi: https://doi.org/10.3389/fonc.2024.1414950. PMID: 39839764
The role of glycolytic condensates in the cellular stress response during cancer progression. Herencia-Lagunar Elena, Carrera-Bravo Claudia a Sztacho Martin. Advances in Biological Regulation [online], 2025, 98, 101104.
doi: https://doi.org/10.1016/j.jbior.2025.101104. PMID: 40902460
Unveiling the role of biomolecular condensates in cellular function and cancer. Elena Herencia-Lagunar, Claudia Carrera-Bravo, Enrique Castano a Martin Sztacho. Advances in Biological Regulation [online], 2025, 98, 101105.
doi: https://doi.org/10.1016/j.jbior.2025.101105. PMID: 40913895
Plasma membrane and nuclear phosphatidylinositol 4,5-bisphosphate signalling in cancer. Chytła Agnieszka, Rattay Stephanie, Akgül Baki a Sztacho Martin. Lipids in Health and Disease [online], 2025, 24(1), 39.
doi: https://doi.org/10.1186/s12944-025-02452-6. PMID: 39915829
Solid Lipid Nanoparticles Coated with Glucosylated poly(2-oxazoline)s: A Supramolecular Toolbox Approach. Elter Johanna K., Sedlák František, Palušák Tomáš, Bernardová Nicol, Lobaz Volodymyr, Tihlaříková Eva, Neděla Vilém, Šácha Pavel a Hrubý Martin. Biomacromolecules [online], 2025, 26(2), 861-882.
doi: https://doi.org/10.1021/acs.biomac.4c01052. PMID: 39779305
Molecular Landscape of Pediatric Low-Grade Gliomas: Insights From RNA-NGS and Bioinformatic Analysis. Brož Petr, Strnadová Martina, Olejníková Denisa, Kotiš Johana, Pospíšilíková Tereza, Mišove Adéla, Koblížek Miroslav, Zámečník Josef, Zápotocký Michal, Sumerauer David, Vícha Aleš, Kynčl Martin, Libý Petr, Beneš Vladimír a Krsková Lenka. Genes, Chromosomes and Cancer [online], 2025, 64(10), e70085.
doi: https://doi.org/10.1002/gcc.70085. PMID: 41074694
NGS‐MRD negativity in post‐HSCT ALL spares unnecessary therapeutic interventions triggered by borderline qPCR results without an increase in relapse risk. Seferna Krystof, Svaton Michael, Rennerova Andrea, Skotnicova Aneta, Reznickova Leona, Valova Tatana, Sedlacek Petr, Riha Petr, Formankova Renata, Keslova Petra, Sramkova Lucie, Stary Jan, Zuna Jan, Kolenova Alexandra, Salek Cyril, Trka Jan a Fronkova Eva. HemaSphere [online], 2025, 9(4), e70124.
doi: https://doi.org/10.1002/hem3.70124. PMID: 40201744
Minimal residual disease assessment following CD19‐targeted therapy in B‐cell precursor acute lymphoblastic leukemia using standardized 12‐color flow cytometry: A EuroFlow study. Verbeek Martijn W. C., Reiterová Michaela, Laqua Anna, Rodríguez Beatriz Soriano, Sedek Lukasz, Buracchi Chiara, Buysse Malicorne, Oliveira Elen, Engelmann Robby, Desterro Joana, De Jong Anja X., Boettcher Sebastian, Jugooa Romana, Barrena Susana, Kohlscheen Saskia, Nierkens Stefan, Rodriques Joana G., Hofmans Mattias, Gaipa Giuseppe, Sobral De Costa Elaine, Mejstrikova Ester, Szczepanski Tomasz, Brüggemann Monika, Van Dongen Jacques J. M., Orfao Alberto a Van Der Velden Vincent H. J.. HemaSphere [online], 2025, 9(4), e70125.
doi: https://doi.org/10.1002/hem3.70125. PMID: 40224162
Clinical Characteristics and Outcomes of Central Nervous System Tumors Harboring NTRK Gene Fusions. Lamoureux Audrey-Anne, Fisher Michael J., Lemelle Lauriane, Pfaff Elke, Amir-Yazdani Pouneh, Kramm Christof, De Wilde Bram, Kazanowska Bernarda, Hutter Caroline, Pfister Stefan M., Sturm Dominik, Jones David T.W., Orbach Daniel, Pierron Gaëlle, Raskin Scott, Drilon Alexander, Diamond Eli L., Harada Guilherme, Zapotocky Michal, Zamecnik Josef, Krskova Lenka, Ellezam Benjamin, Weil Alexander G., Venne Dominic, Barritault Marc, Leblond Pierre, Coltin Hallie, Hammad Rawan, Tabori Uri, Hawkins Cynthia, Hansford Jordan R., Meyran Deborah, Erker Craig, McFadden Kathryn, Sato Mariko, Gottardo Nicholas G., Dholaria Hetal, Nørøxe Dorte Schou, Goto Hiroaki, Ziegler David S., Lin Frank Y., Parsons Donald Williams, Lindsay Holly, Wong Tai-Tong, Liu Yen-Lin, Wu Kuo-Sheng, Franson Andrea T., Hwang Eugene, Aguilar-Bonilla Ana, Cheng Sylvia, Cacciotti Chantel, Massimino Maura, Schiavello Elisabetta, Wood Paul, Hoffman Lindsey M., Cappellano Andréa, Lassaletta Alvaro, Van Damme An, Llort Anna, Gerber Nicolas U., Spalato Ceruso Mariella, Bendel Anne E., Skrypek Maggie, Hamideh Dima, Mushtaq Naureen, Walter Andrew, Jabado Nada, Alsahlawi Aysha, Farmer Jean-Pierre, Coleman Christina, Mueller Sabine, Mazewski Claire, Aguilera Dolly, Robison Nathan J., O’Halloran Katrina, Abbou Samuel, Berlanga Pablo, Geoerger Birgit, Øra Ingrid, Moertel Christopher L., Razis Evangelia D., Vernadou Anastasia, Ducray François, Bronnimann Charlotte, Seizeur Romuald, Clarke Matthew, Resnick Adam C., Alves Mélanie, Jones Chris, Doz François, Laetsch Theodore W. a Perreault Sébastien. Clinical Cancer Research [online], 2025, 31(3), 561-572.
doi: https://doi.org/10.1158/1078-0432.CCR-24-0581. PMID: 39625867
Flow-cytometric MRD detection in pediatric T-ALL: a multicenter AIEOP-BFM consensus-based guided standardized approach. Reiterová Michaela, Kohlscheen Saskia, Maglia Oscar, Sala Simona, Schumich Angela, Maurer-Granofszky Margarita, Faggin Giovanni, Scarparo Pamela, Varotto Elena, Šestáková Zuzana, Švec Peter, Feuerstein Tamar, Vernitsky Helly, Kužílková Daniela, Hrušák Ondřej, Buldini Barbara, Dworzak Michael, Brüggemann Monika, Gaipa Giuseppe a Kalina Tomáš. Clinical Chemistry and Laboratory Medicine (CCLM) [online], 2025, 63(7), 1419-1426.
doi: https://doi.org/10.1515/cclm-2024-1503. PMID: 40068909
Integrative miRNOMe profiling reveals the miR-195-5p–CHEK1 axis and its impact on luminal breast cancer outcomes. Boušková Veronika, Ehrlichová Marie, Spálenková Alžběta, Krus Ivona, Šůsová Simona, Hlaváč Viktor, Němcová Vlasta, Koževnikovová Renata, Trnková Markéta, Vrána David, Gatěk Jiří, Kopečková Kateřina, Mrhalová Marcela, Měšťáková Soňa a Souček Pavel. Molecular Oncology [online], 2025, 19(11), 3409-3426.
doi: https://doi.org/10.1002/1878-0261.70077. PMID: 40548926
Search for germline gene variants in colorectal cancer families presenting with multiple primary colorectal cancers. Försti Asta, Ambrozkiewicz Filip, Marciniak Magdalena, Lubinski Jan a Hemminki Kari. International Journal of Cancer [online], 2025, 156(7), 1393-1403.
doi: https://doi.org/10.1002/ijc.35283. PMID: 39654522
Sex specific familial risk in lung cancer through changing histologies in Sweden. Hemminki Kari, Zitricky Frantisek, Sundquist Kristina, Sundquist Jan, Försti Asta a Hemminki Akseli. International Journal of Cancer [online], 2025, 157(5), 858-866.
doi: https://doi.org/10.1002/ijc.35431. PMID: 40156379
Association of long-term treatment outcomes with changes in PET/MRI characteristics and the type of early treatment response during concurrent radiochemotherapy in patients with locally advanced cervical cancer. Vojtíšek Radovan, Baxa Jan, Hošek Petr, Kovářová Petra, Vítovec Martin, Sukovská Emília, Kosťun Jan, Vlasák Pavel, Presl Jiří, Ferda Jiří a Fínek Jindřich. Strahlentherapie und Onkologie [online], 2025, 201(5), 546-560.
doi: https://doi.org/10.1007/s00066-025-02389-w. PMID: 40163089
Impact of concomitant use of proton pump inhibitors or cardiovascular medication on survival outcomes of patients with metastatic renal cell carcinoma treated with nivolumab. Fiala Ondřej, Hošek Petr, Tkadlecová Michaela, Melichar Bohuslav, Zemánková Anežka, Kopecký Jindřich, Vočka Michal, Matějů Martin, Lohynská Radka, Šiková Dominika, Stránský Petr, Študentová Hana, Spisarová Martina, Nováková Hana, Priester Peter, Kryštofová Dominika, Grmelová Lucie, Büchler Tomáš a Poprach Alexandr. Clinical & Experimental Metastasis [online], 2025, 42(5), 43.
doi: https://doi.org/10.1007/s10585-025-10347-0. PMID: 40751853
Native and decellularized porcine vena cava: Biomechanical and microstructural comparison. Massaro Maria Stefania, Sommer Gerhard, Pukaluk Anna, Wolinski Heimo, Pálek Richard, Červenková Lenka, Ševčík Jan, Rampitsch Katharina, Bolek Lukáš, Liška Václav, Holzapfel Gerhard A. a Moulisová Vladimíra. Acta Biomaterialia [online], 2025, 201, 429-445.
doi: https://doi.org/10.1016/j.actbio.2025.05.071. PMID: 40456303
Native and decellularized porcine vena cava: Histological analysis and in vitro repopulation. Massaro Maria Stefania, Pálek Richard, Malečková Anna, Grajciarová Martina, Červenková Lenka, Polák Robert, Šarčević Sima, Ševčík Jan, Bolek Lukáš, Tonar Zbyněk, Liška Václav a Moulisová Vladimíra. Biomaterials Advances [online], 2025, 177, 214382.
doi: https://doi.org/10.1016/j.bioadv.2025.214382. PMID: 40532651
The use of patient-derived xenografts and patient-derived organoids in the search for new therapeutic regimens for pancreatic carcinoma. A review. Gayibov Emin, Sychra Tomáš, Spálenková Alžběta, Souček Pavel a Oliverius Martin. Biomedicine & Pharmacotherapy [online], 2025, 182, 117750.
doi: https://doi.org/10.1016/j.biopha.2024.117750. PMID: 39689516
Non-viral HCC miRNA profiling reveals miR-1972 as a potential positive prognostic marker. Mallela Venkata Ramana, Rajtmajerová Marie, Ali Esraa, Červenková Lenka, Trailin Andriy, Hošek Petr, Pálek Richard, Daum Ondřej, Liška Václav, Hemminki Kari a Ambrozkiewicz Filip. Non-coding RNA Research [online], 2025, 15, 100-107.
doi: https://doi.org/10.1016/j.ncrna.2025.07.006. PMID: 40896359
Biomarkers, omics and artificial intelligence for early detection of pancreatic cancer. Murray Kate, Oldfield Lucy, Stefanova Irena, Gentiluomo Manuel, Aretini Paolo, O’Sullivan Rachel, Greenhalf William, Paiella Salvatore, Aoki Mateus N., Pastore Aldo, Birch-Ford James, Rao Bhavana Hemantha, Uysal-Onganer Pinar, Walsh Caoimhe M., Hanna George B., Narang Jagriti, Sharma Pradakshina, Campa Daniele, Rizzato Cosmeri, Turtoi Andrei, Sever Elif Arik, Felici Alessio, Sucularli Ceren, Peduzzi Giulia, Öz Elif, Sezerman Osman Uğur, Van Der Meer Robert, Thompson Nathan a Costello Eithne. Seminars in Cancer Biology [online], 2025, 111, 76-88.
doi: https://doi.org/10.1016/j.semcancer.2025.02.009. PMID: 39986585
Therapeutic pancreatic cancer biomarkers and pharmacogenetics. Langer Ales, Soucek Pavel, Vymetalkova Veronika, Rizzato Cosmeri, Bunduc Stefania, Nikas Ilias P., Hlavac Viktor, Kroupa Michal, Farinella Riccardo, Campa Daniele a Mohelnikova-Duchonova Beatrice. Seminars in Cancer Biology [online], 2025, 116, 31-44.
doi: https://doi.org/10.1016/j.semcancer.2025.08.002. PMID: 40921297
Prioritization of predisposition genes for familial non-medullary thyroid cancer by whole-genome sequencing. Srivastava Aayushi, Skopelitou Diamanto, Miao Beiping, Giagiobbe Sara, Paramasivam Nagarajan, Kumar Abhishek, Diquigiovanni Chiara, Bonora Elena, Bandapalli Obul Reddy, Försti Asta a Hemminki Kari. European Journal of Endocrinology [online], 2025, 192(4.0), 398-407.
doi: https://doi.org/10.1093/ejendo/lvaf045. PMID: 40177881
Genetic and environmental associations of nonspecific chromosomal aberrations. Hemminki Kari, Niazi Yasmeen, Vodickova Ludmila, Vodicka Pavel a Försti Asta. Mutagenesis [online], 2025, 40(1.0), 30-38.
doi: https://doi.org/10.1093/mutage/geae006. PMID: 38422374
Dysregulated mitochondrial homeostasis and DNA repair in the progression from colon adenoma to cancer. Danesova Natalie, Horak Josef, Valickova Anna, Gil-Korilis Adrian, Ergui-Arbizu Jorge, Palek Richard, Bruha Jan, Levy Miroslav, Skrobanek Pavel, Kral Jan, Jungwirth Jiri, Neuzil Jiri, Vymetalkova Veronika, Vodicka Pavel, Vodenkova Sona a Tomasova Kristyna. Molecular Medicine [online], 2025, 31(1.0), 341.
doi: https://doi.org/10.1186/s10020-025-01400-5. PMID: 41275076
Age-specific familial risks in cancer as clues to germline genetic and environmental causes: focus on colorectal, endometrial, prostate, kidney, breast and lung cancers. Hemminki Kari, Försti Asta, Hemminki Otto, Scott Rodney J. a Hemminki Akseli. Hereditary Cancer in Clinical Practice [online], 2025, 23(1.0), 7.
doi: https://doi.org/10.1186/s13053-024-00301-8. PMID: 39985094
Prognostic Role of Prostate-specific Antigen Isoforms and Their Early Kinetics in Patients With Metastatic Castration-resistant Prostate Cancer Receiving New Generation Androgen Receptor Targeted Agents. Fiala Ondřej, Hošek Petr, Korunková Hana, Tkadlecová Michaela, Hora Milan, Šiková Dominika, Stránský Petr, Fínek Jindřich, Kučera Radek, Windrichová Jindra a Topolčan Ondřej. In Vivo [online], 2025, 39(2.0), 859-869.
doi: https://doi.org/10.21873/invivo.13889. PMID: 40010964
Percutaneous transthoracic needle biopsy of lung lesions is a safe method associated with a very low risk of pleural recurrence. Svaton Martin, Havel David, Buresova Marcela, Baxa Jan a Hosek Petr. Biomedical Papers [online], 2025, 169(1.0), 21-25.
doi: https://doi.org/10.5507/bp.2024.030. PMID: 39351663
Pembrolizumab versus Pembrolizumab plus Chemotherapy in Non-small Cell Lung Cancer with High PD-L1 Expression - Multicenter Real-world Evidence Study. Svaton Martin, Knetki-Wroblewska Magdalena, Hosek Petr, Chowaniecova Gabriela, Spacek Jan, Fischer Ondrej, Bilek Ondrej, Hrnciarik Michal a Kauffmann-Guerrero Diego. Journal of Cancer [online], 2025, 16(10.0), 3015-3023.
doi: https://doi.org/10.7150/jca.113815. PMID: 40740241
Clusterin Deficiency Promotes Cellular Senescence in Human Astrocytes. Sultana Pinky, Honc Ondrej, Hodny Zdenek a Novotny Jiri. Molecular Neurobiology [online], 2025, 62(5.0), 5774-5786.
doi: https://doi.org/10.1007/s12035-024-04650-2. PMID: 39627493
Determination of translocase isoform ratios in malignancy and cellular senescence. Liblova Zuzana, Maurencova Dominika, Salovska Barbora, Kratky Marek, Mracek Tomas, Korandova Zuzana, Pecinova Alena, Vasicova Pavla, Rysanek David, Andera Ladislav, Fabrik Ivo, Kupcik Rudolf, Kashmel Pavel, Sultana Pinky, Tambor Vojtech, Bartek Jiri, Novak Josef, Vajrychova Marie a Hodny Zdenek. Molecular Oncology [online], 2025, 19(9.0), 2619-2647.
doi: https://doi.org/10.1002/1878-0261.70039. PMID: 40288905
Upregulation of ALDH1 as an adaptive epigenetic response to anthracyclines in acute myeloid leukemia. Leonetti Francesco, Kosanovic Sladjana, Rebollidos‐Rios Rocio, Manosalva Iris, Baier Céline, Yazir Muhube, Constantinescu Andrada, Souaid Charbel, Pequerul Raquel, Adamcova Miroslava Kari, Shaikh Mehak, Havlová Magdalena, Costello Regis, Farrés Jaume, Martin Guillaume, Alberich‐Jorda Meritxell, Spicuglia Salvatore a Perez‐Alea Mileidys. HemaSphere [online], 2025, 9(10.0), e70244.
doi: https://doi.org/10.1002/hem3.70244. PMID: 41164352
Distinct transcriptional changes in hematopoietic progenitor subsets on LPS-induced emergency granulopoiesis. Kosanovic Sladjana, Vanickova Karolina, Milosevic Mirko, Ribeiro Bas Irina, Chilinski Mateusz, Plewczynski Dariusz, Danek Petr, Rohlena Jakub, Rohlenova Katerina a Alberich-Jorda Meritxell. Experimental Hematology [online], 2025, 147, 104792.
doi: https://doi.org/10.1016/j.exphem.2025.104792. PMID: 40316244
Alternatively spliced NFKB1 transcripts enriched in Andean Aymara modulate inflammation, HIF and hemoglobin. Song Jihyun, Han Seonggyun, Amaru Ricardo, Lanikova Lucie, Quispe Teddy, Kim Dongwook, Crawford Jacob E., Kim Soo Jin, Lee Younghee a Prchal Josef T.. Nature Communications [online], 2025, 16(1.0), 1766.
doi: https://doi.org/10.1038/s41467-025-56848-0. PMID: 39971917
Mechanics of cell sheets: plectin as an integrator of cytoskeletal networks. Outla Zuzana, Prechova Magdalena, Korelova Katerina, Gemperle Jakub a Gregor Martin. Open Biology [online], 2025, 15(1.0), 240208.
doi: https://doi.org/10.1098/rsob.240208. PMID: 39875099
Immunotherapy for rapid bone marrow conditioning and leukemia depletion that allows efficient hematopoietic stem cell transplantation. Dal Collo Giada, Grusanovic Srdjan, Rasouli Milad, Van Hoven-Beijen Antoinette, Mueller Yvonne M, Van Der Sande Zara-Li, Van Hagen Martin, Cornelissen Jan J, He Yun, Wang Yuandong, De Pater Emma, Van Der Velden Vincent H J, Raaijmakers Marc H G P, Alberich-Jorda Meritxell, Zhao Jiuqiao, Katsikis Peter D a Erkeland Stefan J. Journal for ImmunoTherapy of Cancer [online], 2025, 13(6.0), e011888.
doi: https://doi.org/10.1136/jitc-2025-011888. PMID: 40579234
Effect of Side Groups on the Surface Parameters and Antifouling Properties of Poly(N-Alkyl Acrylamide)-Coated Surfaces. Kopilec Ondrej, Svoboda Jan, Sivkova Radoslava, Sedlacek Ondrej a Pop‐Georgievski Ognen. Macromolecular Chemistry and Physics [online], 2025, 226(14.0), 70001.
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Desmoplastic tumor priming using clinical-stage corticosteroid liposomes. Ojha Tarun, Schaefer Gideon J.L., Mihyar Rahaf, Pathak Vertika, Ehling Josef, Rama Elena, De Lorenzi Federica, Elshafei Asmaa Said, Moeckel Diana, Elsafy Sara, Theek Benjamin, Wagner Maike, Ceccarini Paolo, Consolino Lorena, Weiler Marek, Peisker Fabian, Caspers Tim, Peña Quim, Barmin Roman, Gremse Felix, Pola Robert, Pechar Michal, Etrych Tomáš, Meurer Steffen, Weiskirchen Ralf, Kramann Rafael, Kiessling Fabian, Storm Gert, Metselaar Josbert a Lammers Twan. Cell Biomaterials [online], 2025, 1(3.0), 100051.
doi: https://doi.org/10.1016/j.celbio.2025.100051. PMID: 40276304
HPMA-based nitroxide radical containing nanoparticles with controlled radical release: Detailed physico-chemical characterization. Klepac Damir, Tavares Marina R., Vragović Martina, Ogrizović Roberta, Valić Srećko, Kereïche Sami, Filippov Sergey K., Etrych Tomáš, Čakara Duško a Chytil Petr. European Polymer Journal [online], 2025, 225, 113727.
doi: https://doi.org/10.1016/j.eurpolymj.2025.113727. PMID: 38826717
Control of the self-assembly and properties of quaternized dextran/heparin polyelectrolyte multilayer films by the degree of dextran substitution. Matiyani Monika, Arjona-Ruiz Carely, Lobaz Volodymyr, Riedel Tomáš, García-Briones Gabriela S., Pop-Georgievski Ognen a Kubies Dana. Journal of Colloid and Interface Science [online], 2025, 696, 137865.
doi: https://doi.org/10.1016/j.jcis.2025.137865. PMID: 40383025
“Grafting-from” synthesis of fluorinated acrylamide polymer brushes: From controlled polymerization to outstanding antifouling properties. Dorado Daza Diego Fernando, De Los Santos Pereira Andres, Kopilec Ondrej, Sivkova Radoslava, Svoboda Jan, Sedlacek Ondrej a Pop-Georgievski Ognen. Polymer [online], 2025, 323, 128175.
doi: https://doi.org/10.1016/j.polymer.2025.128175. PMID: 38826717
Polymer Nanomedicines with pH-Triggered Pirarubicin Release: Revealing the Role of Carrier Hydrophilicity and Release Kinetics in Anticancer Performance. Pytlíková Sára, Jiang Benchun, Woldřichová Lucie, Kotalík Kevin, Androvič Ladislav, Gao Shanghui, Šubr Vladimír, Rumlerová Anna, Pola Robert, Podhorská Natália, Filipová Marcela, Zhang Mingjie, Pechar Michal, Fang Jun, Laga Richard a Etrych Tomáš. Biomacromolecules [online], 2025, 26(10.0), 7013-7023.
doi: https://doi.org/10.1021/acs.biomac.5c01344. PMID: 40947885
Dual Thermo- and pH-Responsive Polymer Nanoparticle Assemblies for Potential Stimuli-Controlled Drug Delivery. Pytlíková Sára, Konefał Rafal, Pola Robert, Braunová Alena, Lobaz Volodymyr, Šlouf Miroslav, Beneš Hynek, Starenko Daniil, Běhalová Kateřina, Kovář Marek, Etrych Tomáš, Laga Richard a Pechar Michal. ACS Applied Bio Materials [online], 2025, 8(1.0), 271-284.
doi: https://doi.org/10.1021/acsabm.4c01167. PMID: 39661715
Mild-Temperature Synthesis of Gold Colloids with Unique Features Mediated by Polymers of Biomedical Interest. Mondo Gabriela Borba, Ribeiro Caroline Arana Da Silva, Turnovská Alžběta, Hrochová Michaela, Etrych Tomáš, Da Silva Fernanda Dias, Giacomelli Cristiano a Giacomelli Fernando C.. ACS Omega [online], 2025, 10(21.0), 21701-21714.
doi: https://doi.org/10.1021/acsomega.5c01123. PMID: 40488100
Selective Glycopolymer Inhibitors of Galectin-3: Supportive Anti-Cancer Agents Protecting Monocytes and Preserving Interferon-Gamma Function. Filipová Marcela, Tavares Marina, Hovorková Michaela, Heine Viktoria, Nekvasilová Pavlína, Křen Vladimír, Etrych Tomáš, Chytil Petr a Bojarová Pavla. International Journal of Nanomedicine [online], 2025, 6591-6609.
doi: https://doi.org/10.2147/IJN.S503381. PMID: 40438186
Nanomedicines for Delivery of Cytarabine: Effect of Carrier Structure and Spacer on the Anti-Lymphoma Efficacy. Pola Robert, Grosmanová Eliška, Pechar Michal, Kostka Libor, Pokorná Eva, Tušková Liliana, Klener Pavel a Etrych Tomáš. Polymers [online], 2025, 17(21.0), 2837.
doi: https://doi.org/10.3390/polym17212837. PMID: 41228599
May the target be with you: polysaccharide-coated upconverting nanoparticles for macrophage targeting. Zajdel Karolina, Lobaz Volodymyr, Ondra Martin, Konefał Rafal, Moravec Oliver, Pop-Georgievski Ognen, Pánek Jiří, Kalita Damian, Sikora-Dobrowolska Bożena, Lenart Lukáš, Hajdúch Marián, Hrubý Martin a Pruszyński Marek. Nanoscale [online], 2025, 17(43.0), 25120-25135.
doi: https://doi.org/10.1039/D5NR01833A. PMID: 41123462
Protein crystallization and structure determination at room temperature in the CrystalChip. Pachl Petr, Coudray Léna, Vincent Romain, Nilles Léa, Scheer Hélène, Ritzenthaler Christophe, Fejfarová Adéla, Řezáčová Pavlína, Engilberge Sylvain a Sauter Claude. FEBS Open Bio [online], 2025, 15(4.0), 532-541.
doi: https://doi.org/10.1002/2211-5463.13932. PMID: 39572886
JHU-2545 preferentially shields salivary glands and kidneys during PSMA-targeted imaging. Nedelcovych Michael T., Dash Ranjeet P., Wu Ying, Choi Eun Yong, Lapidus Rena S., Majer Pavel, Jančařík Andrej, Abou Diane, Penet Marie-France, Nikolopoulou Anastasia, Amor-Coarasa Alex, Babich John, Thorek Daniel L., Rais Rana, Kratochwil Clemens a Slusher Barbara S.. European Journal of Nuclear Medicine and Molecular Imaging [online], 2025, 52(5.0), 1631-1641.
doi: https://doi.org/10.1007/s00259-024-07044-7. PMID: 39743616
Immune checkpoint inhibitors in cancer therapy: what lies beyond monoclonal antibodies?. Zamani Mohammad Reza a Šácha Pavel. Medical Oncology [online], 2025, 42(7.0), 273.
doi: https://doi.org/10.1007/s12032-025-02822-1. PMID: 40536609
CDK2-based CDK7 mimic as a tool for structural analysis: Biochemical validation and crystal structure with SY5609. Škerlová Jana, Krejčiříková Veronika, Peřina Miroslav, Vojáčková Veronika, Fábry Milan, Kryštof Vladimír, Jorda Radek a Řezáčová Pavlína. International Journal of Biological Macromolecules [online], 2025, 294, 139117.
doi: https://doi.org/10.1016/j.ijbiomac.2024.139117. PMID: 39733900
Affinity and Selectivity of Protein–Ligand Recognition: A Minor Chemical Modification Changes Carbonic Anhydrase Binding Profile. Zakšauskas Audrius, Paketurytė-Latvė Vaida, Janku̅naitė Alberta, Čapkauskaitė Edita, Becart Yann, Smirnov Alexey, Pospíšilová Klára, Leitans Janis, Brynda Jiří, Kazaks Andris, Baranauskienė Lina, Manakova Elena, Gražulis Saulius, Kairys Visvaldas, Tars Kaspars, Řezáčová Pavlína a Matulis Daumantas. Journal of Medicinal Chemistry [online], 2025, 68(16.0), 17752-17773.
doi: https://doi.org/10.1021/acs.jmedchem.5c01421. PMID: 40801814
Identification of 6-Aryl-7-Deazapurine Ribonucleoside Phosphonates as Inhibitors of Ecto-5′-Nucleotidase (CD73). Šímová Magdalena, Ormsby Tereza, Šinkevičiu̅tė Ugnė, Sirotová Veselovská Lucia, Čermáková Kateřina, Hadzima Martin, Bartoň Lenka, Staňurová Jana, Kramná Anežka, Šácha Pavel, Tichý Michal, Hocek Michal, Konvalinka Jan a Blazkova Kristyna. ACS Pharmacology & Translational Science [online], 2025, 8(8.0), 2575-2585.
doi: https://doi.org/10.1021/acsptsci.5c00180. PMID: 40810155
Uncovering the glutamate carboxypeptidase II microenvironment using a multi-labeling proteomic approach. Pokorná Jana, Hadzima Martin, Křenková Alena, Smith Joshua D., Šubr Vladimír, Kryštůfek Robin, Hubálek Martin, Starková Jana, Šrámková Karolína, Etrych Tomáš, Kostka Libor, Sedlák František, Konvalinka Jan a Šácha Pavel. Scientific Reports [online], 2025, 15(1.0), 45461.
doi: https://doi.org/10.1038/s41598-025-28826-5. PMID: 41310061
The structural basis of aldo-keto reductase 1C3 inhibition by 17α-picolyl and 17(E)-picolinylidene androstane derivatives. Plavša-Puž Jovana J., Brynda Jiří, Ajduković Jovana J., Bekić Sofija, Ćelić Andjelka, Řezáčová Pavlína, Škerlová Jana a Petri Edward. Journal of Enzyme Inhibition and Medicinal Chemistry [online], 2025, 40(1.0), 2551979.
doi: https://doi.org/10.1080/14756366.2025.2551979. PMID: 40905588
Inhibition of FLT3-ITD Kinase in Acute Myeloid Leukemia by New Imidazo[1,2-b]pyridazine Derivatives Identified by Scaffold Hopping. Břehová Petra, Řezníčková Eva, Škach Kryštof, Jorda Radek, Dejmek Milan, Vojáčková Veronika, Šála Michal, Kovalová Markéta, Dračínský Martin, Dolníková Alexandra, Strmeň Timotej, Kinnertová Monika, Chalupský Karel, Dvořáková Alexandra, Gucký Tomáš, Mertlíková Kaiserová Helena, Klener Pavel, Nencka Radim a Kryštof Vladimír. Journal of Medicinal Chemistry [online], 2023, 66(16.0), 11133-11157.
doi: https://doi.org/10.1021/acs.jmedchem.3c00575. PMID: 37535845
Isoxazole‐Based Compounds Targeting the Taxane‐Binding Site of Tubulin. Peřina Miroslav, Kiss Márton A., Bělíček Jakub, Vojáčková Veronika, Veselá Denisa, Minorics Renáta, Zupko István, Frank Éva a Jorda Radek. Archiv der Pharmazie [online], 2025, 358(7.0), e70031.
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Platelets, Chromogranin A, and C-Reactive Protein Predict Therapy Failure of Metastatic Hormone-Sensitive Prostate Cancer while miR-375 Outperforms Prostate-Specific Antigen in Stratifying Castration-Resistant Prostate Cancer. Chrenková Eva, Spurná Radka, Holá Kateřina, Vrbková Jana, Knillová Jana, Levková Monika, Študentová Hana a Bouchal Jan. The Journal of Molecular Diagnostics [online], 2025, 27(6.0), 446-456.
doi: https://doi.org/10.1016/j.jmoldx.2025.02.006. PMID: 40139458
Novel C-2 Aromatic Heterocycle-Substituted Triterpenoids Inhibit Hedgehog Signaling in GLI1 Overexpression Cancer Cells. Frydrych Ivo, Choma Barbora, Slavíková Lucie, Pokorný Jan, Jakubcová Nikola, Ludha Sandra, Gurská Soňa, Řehulka Jiří, Lišková Barbora, Džubák Petr, Hajdúch Marián a Urban Milan. ACS Omega [online], 2025, 10(10.0), 10617-10632.
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CBL-B – An upcoming immune-oncology target. Fusco Riccardo, Saedi Zeinab, Capriello Imma, Lubskyy Andriy a Dömling Alexander. Expert Opinion on Therapeutic Patents [online], 2025, 35(1.0), 47-64.
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Deletions of LPL and NKX3.1 in Prostate Cancer Progression: Game Changers or By-Standers in Tumor Evolution. Vodičková Tereza, Wozniaková Mária, Židlík Vladimír, Žmolíková Jana, Dvořáčková Jana, Kondé Adéla, Schwarzerová Jana, Grepl Michal a Bouchal Jan. Biomolecules [online], 2025, 15(6.0), 758.
doi: https://doi.org/10.3390/biom15060758. PMID: 40563400
3D-QSAR Design of New Bcr-Abl Inhibitors Based on Purine Scaffold and Cytotoxicity Studies on CML Cell Lines Sensitive and Resistant to Imatinib. Cabezas David, Delgado Thalía, Sepúlveda Guisselle, Krňávková Petra, Vojáčková Veronika, Kryštof Vladimír, Strnad Miroslav, Silva Nicolás Ignacio, Echeverría Javier, Espinosa-Bustos Christian, Mellado Guido, Luo Jiao, Mella Jaime a Salas Cristian O.. Pharmaceuticals [online], 2025, 18(6.0), 925.
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Development of New Pyrazolo [3,4-b]Pyridine Derivatives as Potent Anti-Leukemic Agents and Topoisomerase IIα Inhibitors with Broad-Spectrum Cytotoxicity. Eldehna Wagdy M., Tawfik Haytham O., Veselá Denisa, Vojáčková Veronika, Negmeldin Ahmed T., Elsayed Zainab M., Majrashi Taghreed A., Krňávková Petra, Elbadawi Mostafa M., Shaldam Moataz A., Al-Ansary Ghada H., Kryštof Vladimír a Abdel-Aziz Hatem A.. Pharmaceuticals [online], 2025, 18(11.0), 1770.
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New biomarkers and multiplex tests for diagnosis of aggressive prostate cancer and therapy management. Kral Milan, Kurfurstova Daniela, Zemla Pavel, Elias Martin a Bouchal Jan. Frontiers in Oncology [online], 2025, 15, 1542511.
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CUL4A exhibits tumor-suppressing role via regulation of HUWE1-mediated SMAD3 intracellular shuttling. Danek Veronika, Tureckova Jolana, Huebner Kerstin, Erlenbach-Wuensch Katharina, Baranova Petra, Dobes Jan, Balounova Jana, Simova Michaela, Novosadova Vendula, Madureira Trufen Carlos Eduardo, Prochazkova Michaela, Talacko Pavel, Harant Karel, Barinka Cyril, Beck Inken M., Schneider-Stock Regine, Sedlacek Radislav a Prochazka Jan. Cancer Letters [online], 2025, 621, 217663.
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Structure–Activity Relationships and Biological Insights into PSMA-617 and Its Derivatives with Modified Lipophilic Linker Regions. Schäfer Martin, Bauder-Wüst Ulrike, Roscher Mareike, Motlová Lucia, Kutilová Zsófia, Remde Yvonne, Klika Karel D., Graf Jürgen, Bařinka Cyril a Benešová-Schäfer Martina. ACS Omega [online], 2025, 10(7), 7077-7090.
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Nickel Ferrite Nanoparticles for In Vivo Multimodal Magnetic Resonance and Magnetic Particle Imaging. Herynek Vít, Rajsiglová Lenka, Babič Michal, Švábová Monika, Kohout Jaroslav, Veverka Miroslav, Kmječ Tomáš, Kubíčková Lenka, Karela Jiří, Gregar Filip, Loula Martin, Matějková Stanislava, Šefc Luděk a Vannucci Luca. ACS Applied Nano Materials [online], 2025, 8(29), 14867-14881.
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Quality of life in early breast cancer patients after adjuvant accelerated partial-breast irradiation (APBI) in randomized trial. Burkon Petr, Selingerova Iveta, Vrzal Miroslav, Holanek Milos, Coufal Oldrich, Polachova Katerina, Andraskova Vera, Jhawar Sachin R., Slampa Pavel, Kazda Tomas a Slavik Marek. Scientific Reports [online], 2025, 15(1), 1387.
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Comprehensive profiling of lncRNAs and mRNAs enriched in small extracellular vesicles for early noninvasive detection of colorectal cancer: diagnostic panel assembly and extensive validation. Vychytilova‐Faltejskova Petra, Pavlikova Marketa, Pifkova Lucie, Jugas Robin, Machackova Tana, Radova Lenka, Sachlova Milana, Bartosova Renata, Samoilenko Tetiana, Feckova Zuzana, Orlickova Jana, Slamova Erika, Ponechal Michu Elleni, Al Tukmachi Dagmar, Ruckova Michaela, Vodinska Martina, Kotoucek Jan, Catela Ivkovic Tina, Boudna Marie, Bohovicova Lucia, Stanek Teodor, Halamkova Jana, Svoboda Martin, Prochazka Vladimir, Grolich Tomas, Kala Zdenek a Slaby Ondrej. Molecular Oncology [online], 2025, 19(11), 3445-3462.
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Hypomethylating agents increase L1 retroelement expression without inducing novel insertions in myeloid malignancies. Pavlová Šárka, Svozilová Hana, Krzyžánková Marcela, Sonnek Radim, Volakhava Anastasiya, Smirnova Anastasia, Grigoreva Tatiana, Jašková Zuzana, Synáčková Hana, Wahl Dennis, Bilčíková Michaela, Červinek Libor, Pospíšilová Šárka, Mamedov Ilgar a Plevová Karla. Molecular Oncology [online], 2025, 19(10), 2764-2775.
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Thieno[3,2-b]pyridine: Attractive scaffold for highly selective inhibitors of underexplored protein kinases with variable binding mode. Moyano Paula Martín, Kubina Tadeáš, Paruch Štěpán Owen, Jarošková Aneta, Novotný Jan, Skočková Veronika, Ovesná Petra, Suchánková Tereza, Prokofeva Polina, Kuster Bernhard, Šmída Michal, Chaikuad Apirat, Krämer Andreas, Knapp Stefan, Souček Karel a Paruch Kamil. Angewandte Chemie International Edition [online], 2025, 64(1), e202412786.
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Real‐World Data From a Molecular Tumor Board‐Assisted Cancer Care From a Single Center in The Czech Republic: Is Precision Oncology an Accessible Option, or a Privilege for a Minority of Patients?. Eid Michal, Bednaříková Markéta, Vlažný Jakub, Hausnerová Jitka, Taslerová Renata, Vilmanová Sára, Jelínková Martina, Homolová Alena, Gryc Martin, Trizuljak Jakub, Pavlovský Zdeněk, Tuček Štěpán, Brančíková Dagmar, Bratová Monika, Rohan Tomáš, Kala Zdeněk, Král Zdeněk, Mayer Jiří, Svobodník Adam a Slabý Ondřej. Cancer Medicine [online], 2025, 14(15), e71119.
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Increased thermal stability of FGF10 leads to ectopic signaling during development. Czyrek Aleksandra A., Baran Karolina, Hruba Eva, Horackova Aneta, Bosakova Veronika, Chudzian Julia, Fafilek Bohumil, Laskova Veronika, Stepankova Veronika, Bednar David, Karl Kelly, Kasparek Petr, Bosakova Michaela, Killinger Michal, Szotkowska Tereza, Prochazka Jan, Zieba Jennifer T., Rico-Llanos Gustavo, Fric Jan, Hadzic Stefan, Loku Edma, Wujak Magdalena, Svozilova Katerina, Stroblova Michaela, Sedlacek Radislav, Hristova Kalina, Krakow Deborah, Kubovciak Jan, Delattre Mathys, Bartoszewski Rafal, Buchtova Marcela, Krowarsch Daniel, Chaloupkova Radka, Zakrzewska Malgorzata a Krejci Pavel. Cellular and Molecular Life Sciences [online], 2025, 82(1), 167.
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Individualized therapeutic approaches for relapsed and refractory pediatric ependymomas: a single institution experience. Tinka Pavel, Pokorná Petra, Kýr Michal, Pavelka Zdeněk, Vejmělková Klára, Pálová Hana, Neradil Jakub, Ježová Marta, Slabý Ondřej a Štěrba Jaroslav. Journal of Neuro-Oncology [online], 2025, 173(2), 479-488.
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Discovery of new inhibitors of nuclease MRE11. Nikulenkov Fedor, Carbain Benoit, Biswas Raktim, Havel Stepan, Prochazkova Jana, Sisakova Alexandra, Zacpalova Magdalena, Chavdarova Melita, Marini Victoria, Vsiansky Vit, Weisova Veronika, Slavikova Kristina, Biradar Dhanraj, Khirsariya Prashant, Vitek Marco, Sedlak David, Bartunek Petr, Daniel Lukas, Brezovsky Jan, Damborsky Jiri, Paruch Kamil a Krejci Lumir. European Journal of Medicinal Chemistry [online], 2025, 285, 117226.
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Specific inhibition of fibroblast growth factor receptor 1 signaling by a DNA aptamer. Zlinska Vladimira, Feketova Zuzana, Czyrek Aleksandra, Chudzian Julia, Zivkovic Martina Lenarcic, Ursachi Vlad-Constantin, Dudeja Pooja, Fafilek Bohumil, Rynes Jan, Rico-Llanos Gustavo, Koudelka Adolf, Roy Tanaya, Biadun Martyna, Raskova Vendula, Svozilova Katerina, Stroblova Michaela, Krzyscik Mateusz, Hristova Kalina, Krowarsch Daniel, Foldynova-Trantirkova Silvie, Zakrzewska Malgorzata, Trantirek Lukas a Krejci Pavel. Molecular Therapy Nucleic Acids [online], 2025, 36(1), 102405.
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Engineering Dehalogenase Enzymes Using Variational Autoencoder-Generated Latent Spaces and Microfluidics. Kohout Pavel, Vasina Michal, Majerova Marika, Novakova Veronika, Damborsky Jiri, Bednar David, Marek Martin, Prokop Zbynek a Mazurenko Stanislav. JACS Au [online], 2025, 5(2), 838-850.
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Absence of CDK12 in oocyte leads to female infertility. Jansova Denisa, Sedmikova Veronika, Berro Fatima J., Aleshkina Daria, Dvoran Michal, Kubelka Michal, Rezacova Jitka, Rutarova Jana, Kohoutek Jiri a Susor Andrej. Cell Death & Disease [online], 2025, 16(1), 213.
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Protein structure and interactions elucidated with in-cell NMR for different cell cycle phases and in 3D human tissue models. Rynes Jan, Istvankova Eva, Dzurov Krafcikova Michaela, Luchinat Enrico, Barbieri Letizia, Banci Lucia, Kamarytova Kristyna, Loja Tomas, Fafilek Bohumil, Rico-Llanos Gustavo, Krejci Pavel, Macurek Libor, Foldynova-Trantirkova Silvie a Trantirek Lukas. Communications Biology [online], 2025, 8(1), 194.
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Visual Support for the Loop Grafting Workflow on Proteins. Opálený Filip, Ulbrich Pavol, Planas-Iglesias Joan, Byška Jan, Štourač Jan, Bednář David, Furmanová Katarína a Kozlíková Barbora. IEEE Transactions on Visualization and Computer Graphics [online], 2025, 31(1), 580-590.
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Patterns of SARS-CoV-2-specific humoral and cellular immune response in actively treated patients with solid cancer following prime BNT162b2 COVID-19 vaccination: results from phase IV CoVigi trial. Obermannova Radka Lordick, Selingerova Iveta, Demlova Regina, Okruhlicova Dominika, Nevrlka Jiri, Cerna-Pilatova Katerina, Greplova Kristina, Cermakova Zdenka, Valik Dalibor, Kiss Igor, Palacova Marketa, Poprach Alexandr, Lejdarova Hana, Selvekerova Sarka, Vaneckova Martina a Zdrazilova-Dubska Lenka. Therapeutic Advances in Medical Oncology [online], 2025, 17, 17588359251316224.
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Analysis of extracellular vesicles of frequently used colorectal cancer cell lines. Boudná Marie, Blavet Nicolas, Samoilenko Tetiana, Macháčková Táňa, Jugas Robin, Vychytilová-Faltejsková Petra, Boudný Miroslav, Bartošová Renata, Kotouček Jan, Bystrý Vojtěch, Koželková Kateřina, Slabý Ondřej a Součková Kamila. BMC Cancer [online], 2025, 25(1), 555.
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Creatine kinase B, a downstream effector of c-Myb, controls migration of osteosarcoma cells via regulation of N-cadherin. Pokludová Jana, Lapčík Petr, Zambo Iva Staniczková, Kohoutek Jiří, Zapletalová Danica, Múdry Peter, Adámková Dagmar, Červinka Jakub, Loja Tomáš, Lexa Matej, Verner Jan, Šmarda Jan, Bouchal Pavel, Knopfová Lucia a Beneš Petr. Cancer Cell International [online], 2025, 26(1), 5.
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Advanced NGS analysis of cell-free tumor DNA supports clonal relation to primary high-grade B-cell lymphoma lesion and CNS relapse despite MRI negativity. Navrkalova Veronika, Mareckova Andrea, Porc Jakub, Hricko Samuel, Hrabcakova Viera, Kissova Jarmila, Kundova Sona, Jarosova Marie, Pospisilova Sarka, Kotaskova Jana a Janikova Andrea. Diagnostic Pathology [online], 2025, 20(1), 14.
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Reliable detection of CNS lymphoma-derived circulating tumor DNA in cerebrospinal fluid using multi-biomarker NGS profiling: insights from a real-world study. Navrkalova Veronika, Mareckova Andrea, Hricko Samuel, Hrabcakova Viera, Radova Lenka, Kubes Vaclav, Porc Jakub, Reigl Tomas, Pospisilova Sarka, Kotaskova Jana a Janikova Andrea. Biomarker Research [online], 2025, 13(1), 71.
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Tropomyosin isoforms encoded by TPM2 control the actin-bundling activity of fascin-1. Siatkowska Małgorzata, Robaszkiewicz Katarzyna, Rousová Andrea, Navrátil Jiří, Knopfová Lucia, Talián Gábor, Beneš Petr a Moraczewska Joanna. Biological Research [online], 2025, 58(1), 60.
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MicroRNA Analysis in Meningiomas with Different Degrees of Tissue Stiffness: A Potential Tool for Effective Preoperative Planning. Duba Milos, Al Tukmachi Dagmar, Samoilenko Tetiana, Vecera Marek, Ruckova Michaela, Vankova Tereza, Radova Lenka, Kerkovsky Milos, Dostal Marek, Koprivova Tereza, Roskova Ivana, Mrlian Andrej, Hrdy Ondrej, Duba Jaroslav, Kren Leos, Smrcka Martin, Slaby Ondrej, Fadrus Pavel a Sana Jiri. Neurosurgery [online], 2025, 96(5), 1155-1165.
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Circulating Serum piRNAs as Diagnostic and Prognostic Tools for Clear Cell Renal Cell Carcinoma. Kasik Marek, Iliev Robert, Vychytilova Petra, Rybecka Silvia, Radova Lenka, Stanik Michal, Fedorko Michal, Dolezel Jan, Slaby Ondrej a Bohosova Julia. Cancer Genomics - Proteomics [online], 2025, 22(6), 888-899.
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Blinatumomab in induction therapy improves molecular response in untreated adults with Ph- B-cell precursor acute lymphoblastic leukemia. Salek Cyril, Hrabovsky Stepan, Folber Frantisek, Koristek Zdenek, Horacek Jan M., Fronkova Eva, Reznickova Leona Rezkova, Pecherkova Pavla, Soukup Petr, Dluhosova Barbora, Polivkova Vaclava, Krizkova Jitka, Polakova Katerina Machova, Vrzalova Zuzana, Halamova Hana, Trka Jan, Cetkovsky Petr a Doubek Michael. Haematologica [online], 2025.
doi: https://doi.org/10.3324/haematol.2024.287062. PMID: 39945021
Acridine-Based Chalcone 1C and ABC Transporters. Franko Ondrej, Čižmáriková Martina, Kello Martin, Michalková Radka, Wesołowska Olga, Środa-Pomianek Kamila, Marques Sérgio M., Bednář David, Háziková Viktória, Liška Tomáš Ján a Habalová Viera. International Journal of Molecular Sciences [online], 2025, 26(9), 4138.
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Anticipating protein evolution with successor sequence predictor. Khan Rayyan Tariq, Kohout Pavel, Musil Milos, Rosinska Monika, Damborsky Jiri, Mazurenko Stanislav a Bednar David. Journal of Cheminformatics [online], 2025, 17(1), 34.
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Associations of environmental pollution with pro-oxidant, antioxidant and inflammatory markers in pregnant mothers and newborns. Ambroz Antonin, Klema Jiri, Rossnerova Andrea, Milcova Alena, Pastorkova Anna, Pulkrabova Jana, Parizek Ondrej, Gomersall Veronika, Gramblicka Tomas, Zelenka Jaroslav, Ruml Tomas, Vrzackova Nikola, Veleminsky Milos, Hasan Newroz, Topinka Jan, Sram Radim J. a Rossner Pavel. Frontiers in Toxicology [online], 2025, 7, 1572486.
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Transcriptomic Profiling of Mouse Mesenchymal Stem Cells Exposed to Metal-Based Nanoparticles. Sima Michal, Libalova Helena, Simova Zuzana, Echalar Barbora, Palacka Katerina, Cervena Tereza, Klema Jiri, Krejcik Zdenek, Holan Vladimir a Rossner Pavel. International Journal of Molecular Sciences [online], 2025, 26(15), 7583.
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Interaction of Selected Anthracycline and Tetracycline Chemotherapeutics with Poly(I:C) Molecules. Skaličková Markéta, Abramenko Nikita, Charnavets Tatsiana, Vellieux Frédéric, Leischner Fialová Jindřiška, Kučnirová Kateřina, Kejík Zdeněk, Masařík Michal, Martásek Pavel, Pacak Karel, Pacák Tomáš a Jakubek Milan. ACS Omega [online], 2025, 10(16), 15935-15946.
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Injecting hope: the potential of intratumoral immunotherapy for locally advanced and metastatic cancer. Skalickova Marketa, Hadrava Vanova Katerina, Uher Ondrej, Leischner Fialova Jindriska, Petrlakova Katerina, Masarik Michal, Kejík Zdeněk, Martasek Pavel, Pacak Karel a Jakubek Milan. Frontiers in Immunology [online], 2025, 15, 1479483.
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The potential of exosomes in regenerative medicine and in the diagnosis and therapies of neurodegenerative diseases and cancer. Odehnalová Nikola, Šandriková Viera, Hromadka Róbert, Skaličková Markéta, Dytrych Petr, Hoskovec David, Kejík Zdeněk, Hajduch Jan, Vellieux Frédéric, Vašáková Martina Koziar, Martásek Pavel a Jakubek Milan. Frontiers in Medicine [online], 2025, 12, 1539714.
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Deficiency of miR-155 in Leukemic B-Cells Results in Cell Cycle Arrest and Deregulation of MIR155HG/TP53INP1/CDKN1A/CCND1 network. Golovina Elena, Kokavec Juraj, Kazantsev Dmitry, Yurikova Oxana, Bajecny Martin, Savvulidi Filipp Georgijevic, Simersky Radim, Lenobel Rene, Tost Jorg, Herynek Vit, Sefc Ludek, Sebela Marek, Klener Pavel, Zemanova Zuzana, Stopka Tomas a Vargova Karina Savvulidi. Archives of Medical Research [online], 2025, 56(3), 103124.
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The HOX code of human adult fibroblasts reflects their ectomesenchymal or mesodermal origin. Pfeiferová Lucie, Španko Michal, Šáchová Jana, Hradilová Miluše, Pienta Kenneth J., Valach Jaroslav, Machoň Vladimír, Výmolová Barbora, Šedo Aleksi, Bušek Petr, Szabo Pavol, Lacina Lukáš, Gál Peter, Kolář Michal a Smetana Karel. Histochemistry and Cell Biology [online], 2025, 163(1), 38.
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Gamma smooth muscle actin as a new potential marker of cancer-associated fibroblasts. Španko Michal, Pfeiferová Lucie, Krejčí Eliška Drobná, Kolář Michal, Dundr Pavel, Valach Jaroslav, Smetana Karel a Lacina Lukáš. Histochemistry and Cell Biology [online], 2025, 163(1), 93.
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Cold, Hot, and Lethal—The Tumour Microenvironment and the Immunology of Head and Neck Squamous Cell Carcinoma. Vyhnánková Svatava, Lacina Lukáš, Chovanec Martin, Plzák Jan, Smetana Karel, Netušil Jiří, Kolář Michal a Šindelka Radek. International Journal of Molecular Sciences [online], 2025, 26(18), 8844.
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The perinucleolar compartment and the oncogenic super-enhancers are part of the same phase-separated structure filled with phosphatidylinositol 4,5-bisphosphate and long non-coding RNA HANR. Miladinović Ana, Antiga Ludovica, Venit Tomáš, Bayona-Hernandez Andrea, Červenka Jakub, Labala Rajendra Kumar, Kolář Michal, Castaño Enrique, Sztacho Martin a Hozák Pavel. Advances in Biological Regulation [online], 2025, 95, 101069.
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Lipid−lncRNA Crossroads: An Overview of Interactions Between Lipids and lncRNA. Bayona-Hernandez Andrea, Miladinović Ana, Antiga Ludovica, Hozak Pavel, Sztacho Martin a Castano Enrique. Cells [online], 2025, 14(15), 1193.
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Pooled analysis of 3,741 stool metagenomes from 18 cohorts for cross-stage and strain-level reproducible microbial biomarkers of colorectal cancer. Piccinno Gianmarco, Thompson Kelsey N., Manghi Paolo, Ghazi Andrew R., Thomas Andrew Maltez, Blanco-Míguez Aitor, Asnicar Francesco, Mladenovic Katarina, Pinto Federica, Armanini Federica, Punčochář Michal, Piperni Elisa, Heidrich Vitor, Fackelmann Gloria, Ferrero Giulio, Tarallo Sonia, Nguyen Long H., Yan Yan, Keles Nazim A., Tuna Bilge G., Vymetalkova Veronika, Trompetto Mario, Liska Vaclav, Hucl Tomas, Vodicka Pavel, Bencsiková Beatrix, Čarnogurská Martina, Popovici Vlad, Marmorino Federica, Cremolini Chiara, Pardini Barbara, Cordero Francesca, Song Mingyang, Chan Andrew T., Derosa Lisa, Zitvogel Laurence, Huttenhower Curtis, Naccarati Alessio, Budinska Eva a Segata Nicola. Nature Medicine [online], 2025, 31(7), 2416-2429.
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DNA damage in oral mucosal epithelial cells cultured in complex and xenobiotic-free media: a comparison study. Cabral Joao Victor, Vodenkova Sona, Tomasova Kristyna, Vodickova Ludmila, El Yamani Naouale, Rundén Pran Elise, Dusinska Maria, Safanda Adam a Jirsova Katerina. Mutagenesis [online], 2025, 40(3), 526-532.
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Microtubule‐associated <span style="font-variant:small-caps;">NAV3</span> regulates invasive phenotypes in glioblastoma cells. Škarková Aneta, Pelantová Markéta, Tolde Ondřej, Legátová Anna, Mateu Rosana, Bušek Petr, Garcia‐Borja Elena, Šedo Aleksi, Etienne‐Manneville Sandrine, Rösel Daniel a Brábek Jan. Brain Pathology [online], 2025, 35(1), e13294.
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Development of a new flippase-dependent mouse model for red fluorescence-based isolation of KRASG12D oncogene-expressing tumor cells. Hrckulak Dusan, Onhajzer Jakub, Krausova Michaela, Stastna Monika, Kriz Vitezslav, Janeckova Lucie a Korinek Vladimir. Transgenic Research [online], 2025, 34(1), 9.
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Germline Jak2-R1063H mutation interferes with normal hematopoietic development and increases risk of thrombosis and leukemic transformation. Zimolova Veronika, Burocziova Monika, Berkova Linda, Grusanovic Srdjan, Gursky Jan, Janotka Lubos, Kasparek Petr, Pecinova Alena, Kundrat David, Hrckulak Dusan, Onhajzer Jakub, Jeziskova Ivana, Nekvindova Lucie, Weinbergerova Barbora, Pospisilova Sarka, Doubek Michael, Alberich-Jorda Meritxell, Korinek Vladimir, Divoky Vladimir a Lanikova Lucie. Leukemia [online], 2025, 39(11), 2745-2757.
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In-frame germline TP53 variant impairs p53 oligomerization and predisposes to cancer. Vanikova Lucie, Machackova Eva, Nemcova Barbora, Soukupova Jana, Petrezselyova Silvia, Novakova Klara, Zenatova Marcela, Pavlova Sarka, Kleiblova Petra, Kleibl Zdenek, Foretova Lenka a Macurek Libor. Scientific Reports [online], 2025, 15(1), 30459.
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Live-cell magnetic manipulation of recycling endosomes reveals their direct effect on actin protrusions to promote invasive migration. Gemperle Jakub, Liße Domenik, Kappen Marie, Secret Emilie, Coppey Mathieu, Gregor Martin, Menager Christine, Piehler Jacob a Caswell Patrick. Science Advances [online], 2025, 11(27), eadu6361.
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Regulation of microtubule nucleation in glioblastoma cells by ARF GTPase-activating proteins GIT1 and GIT2 and protein kinase C. Sulimenko Vadym, Dráberová Eduarda, Sládková Vladimíra, Sulimenko Tetyana, Vosecká Věra, Skalli Omar a Dráber Pavel. Cancer Cell International [online], 2025, 25(1), 125.
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Tcf4 regulates secretory cell fate decisions in the small intestine and colon tumors: insights from transcriptomic, histological, and microbiome analyses. Janeckova Lucie, Stastna Monika, Hrckulak Dusan, Berkova Linda, Kubovciak Jan, Onhajzer Jakub, Kriz Vitezslav, Dostalikova Stela, Mullerova Tereza, Vecerkova Katerina, Tenglerova Marketa, Coufal Stepan, Kostovcikova Klara, Blumberg Richard S., Filipp Dominik, Basler Konrad, Valenta Tomas, Kolar Michal a Korinek Vladimir. Stem Cell Research & Therapy [online], 2025, 16(1), 170.
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Plectin-mediated cytoskeletal crosstalk as a target for inhibition of hepatocellular carcinoma growth and metastasis. Outla Zuzana, Oyman-Eyrilmez Gizem, Korelova Katerina, Prechova Magdalena, Frick Lukas, Sarnova Lenka, Bisht Piyush, Novotna Petra, Kosla Jan, Bortel Patricia, Borutzki Yasmin, Bileck Andrea, Gerner Christopher, Rahbari Mohammad, Rahbari Nuh, Birgin Emrullah, Kvasnicova Bibiana, Galisova Andrea, Sulkova Katerina, Bauer Andreas, Jobe Njainday, Tolde Ondrej, Sticova Eva, Rösel Daniel, O'Connor Tracy, Otahal Martin, Jirak Daniel, Heikenwälder Mathias, Wiche Gerhard, Meier-Menches Samuel M a Gregor Martin. eLife [online], 2025, 13, RP102205.
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Dynamics of compartment-specific proteomic landscapes of hepatotoxic and cholestatic models of liver fibrosis. Jirouskova Marketa, Harant Karel, Cejnar Pavel, Ojha Srikant, Korelova Katerina, Sarnova Lenka, Sticova Eva, Mayr Christoph H, Schiller Herbert B a Gregor Martin. eLife [online], 2025, 13, RP98023.
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Antibody polymer drug conjugates with increased drug to antibody ratio: CD38-targeting nanomedicines for innovative therapy of relapsed lymphomas. Lidický Ondřej, Renešová Nicol, Kudláčová Júlia, Filipová Marcela, Běláková Tereza, Kovaříková Petra, Manakov Dmitry, Pankrác Jan, Dolníková Alexandra, Pokorná Eva, Klener Pavel a Etrych Tomáš. Journal of Controlled Release [online], 2025, 384, 113876.
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Theranostic Verteporfin-Conjugated Upconversion Nanoparticles for Cancer Treatment. Shapoval Oleksandr, Patsula Vitalii, Větvička David, Šlouf Miroslav, Kabešová Martina, Vasylyshyn Taras, Svobodová Ludmila Maffei, Konefal Magdalena, Kočková Olga, Pankrác Jan, Matouš Petr, Herynek Vít a Horák Daniel. Nanomaterials [online], 2025, 15(22), 1690.
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Synthesis and Biological Activity of 2,6‐Disubstituted 7‐Deazapurine Ribonucleosides. Šinkevičiūtė Ugnė, Dvořáková Marcela, Tichý Michal, Gurská Soňa, Ječmeňová Kateřina, Poštová Slavětínská Lenka, Džubák Petr, Hajdúch Marián a Hocek Michal. European Journal of Organic Chemistry [online], 2025, 28(5.0), e202401187.
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On-Resin Assembly of Macrocyclic Inhibitors of Cryptococcus neoformans May1: A Pathway to Potent Antifungal Agents. Kryštůfek Robin, Verner Václav, Šácha Pavel, Hadzima Martin, Trajhan Filip, Starková Jana, Tloušt’ová Eva, Dvořáková Alexandra, Pecina Adam, Brynda Jiří, Chalupský Karel, Hájek Miroslav, Boucher Michael J., Majer Pavel, Řezáč Jan, Madhani Hiten D., Craik Charles S. a Konvalinka Jan. Journal of Medicinal Chemistry [online], 2025, 68(9.0), 9623-9637.
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Isoform-Directed Control of c-Myc Functions: Understanding the Balance from Proliferation to Growth Arrest. Kubickova Agata, De Sanctis Juan a Hajduch Marian. International Journal of Molecular Sciences [online], 2023, 24(24.0), 17524.
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Minimal residual disease and prognostic significance of circulating tumour cells in early-stage colorectal cancer. Tolmaci Benjamin, Stejskal Pavel, Zuffa Peter, Rehulkova Alona, Kourilova Pavla, Berta Emil, Hajduch Marian, Klein Jiri a Srovnal Josef. Biomedical Papers [online], 2025.
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PET/CT imaging of esophageal cancer targeting tumor cell specific αvβ6-integrin expression. Bendová Kateřina Dvořáková, Groll Tanja, Neužilová Barbora, Krasulová Kristýna, Nový Zbyněk, Reissig Falco, Steiger Katja, Boxberg Melanie, Eppard Elisabeth, Wuestemann Jan, Hajdúch Marián, Jesinghaus Moritz, Šimeček Jakub, Kreissl Michael C., Petřík Miloš a Notni Johannes. European Journal of Nuclear Medicine and Molecular Imaging [online], 2025, 53(1.0), 607-618.
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Pre-existing cell subpopulations in primary prostate cancer tumors display surface fingerprints of docetaxel-resistant cells. Drápela Stanislav, Kvokačková Barbora, Slabáková Eva, Kotrbová Anna, Gömöryová Kristína, Fedr Radek, Kurfürstová Daniela, Eliáš Martin, Študent Jr Vladimír, Lenčéšová Frederika, Ranjani Ganji Sri, Pospíchalová Vendula, Bryja Vítězslav, Van Weerden Wytske M., Puhr Martin, Culig Zoran, Bouchal Jan a Souček Karel. Cellular Oncology [online], 2025, 48(1.0), 205-218.
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Surface-enhanced Raman spectroscopy-assisted lateral flow test for adenine and IgG analysis. Chaloupková Zuzana, Gajdošová Klára, Poláková Kateřina a Ranc Václav. Analytica Chimica Acta [online], 2025, 1376, 344595.
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Identification of a novel Azaspirooxindolinone-based PROTAC for selective BTK degradation and enhanced anticancer activity. Rampeesa Naveen Kumar, Gundla Rambabu, Mudasani Gopal, Tangallapalli Sudhakar, Anugu Sreenivasa Reddy, Gurská Soňa, De Sanctis Juan Bautista, Džubák Petr, Hajdúch Marián a Das Viswanath. Bioorganic Chemistry [online], 2025, 157, 108316.
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Synthesis and evaluation of cyclobut-3-ene-1,2-dione-3-hydrazones with benzothiazole moiety as novel anticancer agents inducing nonapoptotic oncosis-like cell death. Srovnalová Alžběta, Kaplánek Robert, Kejík Zdeněk, Hajduch Jan, Gurská Soňa, Martásek Pavel, Hajdúch Marián, Džubák Petr a Jakubek Milan. Biomedicine & Pharmacotherapy [online], 2025, 190, 118404.
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Design, synthesis, and biological evaluation of novel azaspirooxindolinone derivatives as potent inhibitors of ITK and BTK-dependent cancers. Mudasani Gopal, Rampeesa Naveen Kumar, Anugu Sreenivasa Reddy, Muddasani Pullareddy, Gurská Soňa, Džubák Petr, Hajdúch Marián, Das Viswanath a Gundla Rambabu. Bioorganic & Medicinal Chemistry [online], 2025, 121, 118116.
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Triterpenoid phthalimides as selective anti-cancer agents targeting mitochondrial apoptosis. Kazakova Anna, Frydrych Ivo, Jakubcová Nikola, Pokorný Jan, Lišková Barbora, Gurská Soňa, Buriánová Renata, Přibylka Adam, Džubák Petr, Hajdúch Marián a Urban Milan. European Journal of Medicinal Chemistry [online], 2025, 283, 117126.
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Triterpenoid derivatives inhibit Gli-mediated transcription in human glioblastoma cell line via direct interaction with Gli1. Frydrych Ivo, Řehulka Jiří, Slavíková Lucie, Hodoň Jiří, Pokorný Jan, Šidová Veronika, Medvedíková Martina, Slavík Hanuš, Polishchuk Pavel, Oždian Tomáš, Vrbková Jana, Šarek Jan, Džubák Petr, Hajdúch Marián a Urban Milan. Journal of Biological Chemistry [online], 2025, 301(9.0), 110472.
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The kinetics of uracil-N-glycosylase distribution inside replication foci. Ligasová Anna, Frydrych Ivo, Piskláková Barbora, Friedecký David a Koberna Karel. Scientific Reports [online], 2025, 15(1.0), 3026.
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High-risk HPV prevalence in the Czech cervical cancer screening population: a comparison of clinician-collected and self-collected sampling. Jaworek Hana, Bouska Ondrej, Kourilova Pavla, Hajduch Marian a Koudelakova Vladimira. European Journal of Public Health [online], 2025, 35(4.0), 760-765.
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In vitro and in vivo evaluation of anti-HER2 antibody conjugates labelled with 225Ac. Ondrák Fialová Kateřina, Ondrák Lukáš, Vlk Martin, Kozempel Ján, Nováková Kateřina, Nový Zbyněk, Hajduová Katarína, Hajdúch Marián, Petřík Miloš, Pruszynski Marek, Bruchertseifer Frank a Morgenstern Alfred. EJNMMI Radiopharmacy and Chemistry [online], 2025, 10(1.0), 16.
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It’s a match: use of the radionuclide theranostic pair 133La/225Ac for the radiopharmacological characterization of EGFR-targeted single-domain antibodies. Trommer Johanna, Ullrich Martin, Reissig Falco, Brühlmann Santiago Andres, Nitt-Weber Anne-Kathrin, Novy Zbynek, Hajduova Katarina, Kurfurstova Daniela, Hendrychova Romana, Bouchal Jan, Petrik Milos, Neuber Christin, Sihver Wiebke, Stadlbauer Sven, Pietzsch Jens, Kreller Martin, Kopka Klaus, Mamat Constantin a Zarschler Kristof. EJNMMI Radiopharmacy and Chemistry [online], 2025, 10(1.0), 31.
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Magnetic 2D Transition-Metal-Based Nanomaterials in Biomedicine: Opportunities and Challenges in Cancer Therapy. Sukur Sunčica a Ranc Václav. Materials [online], 2025, 18(11.0), 2570.
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New Derivatives of Caracasine Acid with Anti-Leukemic Activity and Limited Effectiveness in Spheroid Cultures. Suárez Alírica Isabel, Chávez Katiuska, Garmendia Jenny Valentina, De Sanctis Claudia Valentina, Gurská Soňa, Džubák Petr, Hajduch Marian a De Sanctis Juan Bautista. Pharmaceuticals [online], 2025, 18(7.0), 1043.
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Colchicine-BODIPY Probes: Evidence for the Involvement of Intracellular Membranes in the Targeting of Colchicine to Tubulin. Jurášek Michal, Dráberová Eduarda, Řehulka Jiří, Gurská Soňa, Ivanova Aleksandra, Polishchuk Pavel, Ječmeňová Kateřina, Fähnrich Jan, Marešová Anna, Tauchen Jan, Romero Atilio Reyes, Dömling Alexander, Hajdúch Marián, Drašar Pavel B., Dráber Pavel a Džubák Petr. ACS Pharmacology & Translational Science [online], 2025, 8(7.0), 1965-1985.
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Paving the way for future PSMA inhibitors: insights from comparative preclinical evaluations of structure modifications. Hajduová Katarína, Bendová Kateřina Dvořáková, Petřík Miloš, Benešová-Schäfer Martina, Schäfer Martin, Hajdúch Marián a Nový Zbyněk. EJNMMI Radiopharmacy and Chemistry [online], 2025, 10(1.0), 63.
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Why sex and gender matter in cancer research and care. Stanková Jarmila a Hajdúch Marián. Klinicka onkologie [online], 2025, 38(6.0).
doi: https://doi.org/10.48095/ccko2025436. PMID: 41553809
Increasing recombinant protein production in E. coli via FACS‐based selection of N‐terminal coding DNA libraries. Herynek Štěpán, Svoboda Jakub, Huličiak Maroš, Peleg Yoav, Škultétyová Ľubica, Mikulecký Pavel a Schneider Bohdan. The FEBS Journal [online], 2025, 292(5.0), 1070-1085.
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Production and inhibition of human Heparan 6-O-Endosulfatase SULF1. Aljuhani Reem, Benicky Julius, Panigrahi Aswini, Mukherjee Pritha, Sanda Miloslav, Zhu Shiya, Nováková Zora, Pomin Vitor H, Liu Jian, Davidson Bruce, Bařinka Cyril a Goldman Radoslav. Glycobiology [online], 2025, 35(12.0), cwaf059.
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Immunologically active cell wall polysaccharides of green microalga Dictyosphaerium chlorelloides (Chlorellacea). Sushytskyi Leonid, Synytsya Andriy, Lukáč Pavol, Rajsiglová Lenka, Capek Peter, Pohl Radek, Bleha Roman, Vannucci Luca E., Smrz Daniel, Čopíková Jana a Kaštánek Petr. Carbohydrate Polymers [online], 2025, 353, 123242.
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A first-in-class non-cytotoxic nanocarrier based on a recombinant human ferritin boosts targeted therapy, chemotherapy and immunotherapy. Tisci Giada, Rajsiglova Lenka, Bibbo Sandra, Ziccheddu Giovanna, Ricciardi Elena, Falvo Elisabetta, De Laurenzi Vincenzo, Sala Gianluca, Capone Emily, Colotti Gianni, Arcovito Alessandro, Giacon Noah, Makovický Peter, Sushytskyi Leonid, Lukac Pavol, Vannucci Luca, Giacomini Patrizio a Ceci Pierpaolo. International Journal of Biological Macromolecules [online], 2025, 309, 142843.
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Overcoming P-glycoprotein-mediated multidrug resistance in cancer cells through micelle-forming PHPMA-b-PPO diblock copolymers for doxorubicin delivery. Kaňa Martin, Braunová Alena, Starenko Daniil, Frejková Markéta, Bouček Jan, Říhová Blanka, Kovář Marek, Etrych Tomáš a Šírová Milada. Journal of Controlled Release [online], 2025, 381, 113645.
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Temporal optimization of CD25-biased IL-2 agonists and immune checkpoint blockade leads to synergistic anticancer activity despite robust regulatory T cell expansion. Kilic Irfan Baki, Weberova Petra, VanDyke Derek, Sirova Milada, Kubesova Katerina, Fabilane Charina S, Mazhara Vladyslav, Liu Kathy, Behalova Katerina, Ptacek Bohumil, Rihova Blanka, Spangler Jamie B a Kovar Marek. Journal for ImmunoTherapy of Cancer [online], 2025, 13(8.0), e010465.
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Novel PD-1-targeted, activity-optimized IL-15 mutein SOT201 acting in cis provides antitumor activity superior to PD1-IL2v. Matuskova Hana, Marasek Pavel, Mazhara Vladyslav, Simonova Ekaterina, Kosinova Lucie, Danek Petr, Danova Klara, Sajnerova Katerina, Malatova Iva, Hrabankova Klara, Greco Denise, Martinec Ondrej, Fabisik Matej, Podzimkova Nada, Hladikova Kamila, Behalova Katerina, Antosova Zuzana, Sirova Milada, Mikyskova Romana, Reinis Milan, Kovar Marek, Béchard David, Moebius Ulrich, Palova Jelinkova Lenka, Spisek Radek, Steegmaier Martin a Adkins Irena. Journal for ImmunoTherapy of Cancer [online], 2025, 13(4.0), e010736.
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Impact of galectin-1's redox state on its lectin activity and monomer-dimer equilibrium. Focusing on oxidized Gal-1. Staroňová Tatiana, Holčáková Jitka, Voňka Petr, Hrstka Roman a Ostatná Veronika. International Journal of Biological Macromolecules [online], 2025, 295, 139452.
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FoxO1 signaling in B cell malignancies and its therapeutic targeting. Hlavac Krystof, Pavelkova Petra, Ondrisova Laura a Mraz Marek. FEBS Letters [online], 2025, 599(20.0), 2911-2931.
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Robust acute myeloid leukemia engraftment in humanized scaffolds using injectable biomaterials and intravenous xenotransplantation. Busa Daniel, Herudkova Zdenka, Hyl Jan, Vlazny Jakub, Sokol Filip, Matulova Kvetoslava, Folta Adam, Hynst Jakub, Vojtova Lucy, Kren Leos, Repko Martin, Racil Zdenek, Mayer Jiri a Culen Martin. Molecular Oncology [online], 2025, 19(5.0), 1371-1385.
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Clinical and Prognostic Significance of Additional Chromosomal Abnormalities at Diagnosis of Chronic Myeloid Leukemia. Mayer Jiří, Čičátková Petra, Kováčová Lenka, Jarošová Marie, Karas Michal, Jindra Pavel, Klamová Hana, Poláková Kateřina Machová, Černá Olga, Cmunt Eduard, Bělohlávková Petra, Žák Pavel, Faber Edgar, Papajík Tomáš, Stejskal Lukáš, Ježíšková Ivana, Weinbergerová Barbora, Jurček Tomáš, Horňák Tomáš, Žáčková Daniela, Ransdorfová Šárka, Holzerová Milena a Pavlík Tomáš. American Journal of Hematology [online], 2025, 100(4.0), 729-734.
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Detection of clinically relevant variants in the TP53 gene below 10% allelic frequency: A multicenter study by ERIC, the European Research Initiative on CLL. Pavlova Sarka, Malcikova Jitka, Radova Lenka, Bonfiglio Silvia, Cowland Jack B., Brieghel Christian, Andersen Mette K., Karypidou Maria, Biderman Bella, Doubek Michael, Lazarian Gregory, Rapado Inmaculada, Vynck Matthijs, Porret Naomi A., Andres Martin, Rosenberg Dina, Sahar Dvora, Martínez‐Laperche Carolina, Buño Ismael, Hindley Andrew, Donaldson David, Sánchez Julio B., García‐Marco José A., Serrano‐Alcalá Alicia, Ferrer‐Lores Blanca, Fernández‐Rodriguez Concepción, Bellosillo Beatriz, Stilgenbauer Stephan, Tausch Eugen, Nikdin Hero, Quinn Fiona, Atkinson Emer, Van De Corput Lisette, Yildiz Cafer, Bilbao‐Sieyro Cristina, Florido Yanira, Thiede Christian, Schuster Caroline, Stoj Anastazja, Czekalska Sylwia, Chatzidimitriou Anastasia, Laidou Stamatia, Bidet Audrey, Dussiau Charles, Nollet Friedel, Piras Giovanna, Monne Maria, Smirnova Svetlana, Nikitin Eugene, Sloma Ivan, Claudel Alexis, Largeaud Laetitia, Ysebaert Loïc, Valk Peter J. M., Christian Amy, Walewska Renata, Oscier David, Sebastião Marta, Da Silva Maria Gomes, Galieni Piero, Angelini Mario, Rossi Davide, Spina Valeria, Matos Sónia, Martins Vânia, Stokłosa Tomasz, Pepek Monika, Baliakas Panagiotis, Andreu Rafa, Luna Irene, Kahre Tiina, Murumets Ülle, Pikousova Tereza, Kurucova Terezia, Laird Sophie, Ward Daniel, Alcoceba Miguel, Balanzategui Ana, Scarfo Lydia, Gandini Francesca, Zapparoli Ettore, Blanco Adoración, Abrisqueta Pau, Rodríguez‐Vicente Ana E., Benito Rocío, Bravetti Clotilde, Davi Frédéric, Gameiro Paula, Martinez‐Lopez Joaquin, Tazón‐Vega Bárbara, Baran‐Marszak Fanny, Davis Zadie, Catherwood Mark, Sudarikov Andrey, Rosenquist Richard, Niemann Carsten U., Stamatopoulos Kostas, Ghia Paolo a Pospisilova Sarka. HemaSphere [online], 2025, 9(1.0), e70065.
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MicroRNA Profiling of Bone Marrow Plasma Extracellular Vesicles in Multiple Myeloma, Extramedullary Disease, and Plasma Cell Leukemia. Gregorova Jana, Vlachova Monika, Vychytilova‐Faltejskova Petra, Dostalova Adela, Ruzickova Tereza, Vecera Marek, Radova Lenka, Pospichalova Vendula, Sladecek Stanislava, Hyzdalova Martina, Kotaskova Jana, Jarosova Marie, Masek Josef, Benesova Klara, Jarkovsky Jiri, Rihova Lucie, Bezdekova Renata, Almasi Martina, Boichuk Ivanna, Stork Martin, Pour Ludek a Sevcikova Sabina. Hematological Oncology [online], 2025, 43(1.0), e70036.
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Data‐Independent Acquisition Mass Spectrometry in Tumor Classification and Cancer Biomarker Research. Simonik Jan, Lapcik Petr, Bouchalova Pavla a Bouchal Pavel. Mass Spectrometry Reviews [online], 2025, mas.70014.
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Total psoriasis regression in a patient with chronic myeloid leukemia treated using nilotinib. Horňák Tomáš, Žáčková Daniela a Mayer Jiří. Annals of Hematology [online], 2025, 104(3.0), 2001-2004.
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Potential differences between real-life and randomized controlled trial populations in chronic myeloid leukemia. Horňák Tomáš, Žáčková Daniela a Mayer Jiří. Annals of Hematology [online], 2025, 104(11.0), 6105-6108.
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Establishment of Coala: a novel 3D and 2D cancer cell line derived from colorectal cancer liver metastasis. Mersakova Sandra, Marcinek Juraj, Brany Dusan, Chodelkova Olga, Vorcak Martin, Cermak Martin, Poturnajova Martina, Kozovska Zuzana, Skovierova Henrieta, Novakova Slavomira, Mitruskova Barbora, Loderer Dusan, Grendar Marian, Holubekova Veronika, Hornakova Andrea, Melegova Jana, Brozmanova Mariana, Palkoci Blazej, Vojtko Martin, Kycina Roman, Pindura Miroslav, Janik Jan, Mikolajcik Peter, Gabonova Eva, Laca Ludovit, Nicodemou Andreas, Danisovic Lubos, Plank Lukas, Halasova Erika, Mraz Marek, Matuskova Miroslava, Lasabova Zora, Kalman Michal a Strnadel Jan. Human Cell [online], 2025, 38(5.0), 137.
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PD-L1 Clones and Their Relevance in Glioblastoma, IDH-Wildtype: A Comparative Analysis. Hendrych Michal, Vana Frantisek, Hermanova Marketa, Lakomy Radek, Kazda Tomas, Matulova Kvetoslava, Kopkova Alena, Jelinkova Martina, Jancalek Radim, Smrcka Martin, Vybihal Vaclav a Sana Jiri. Bratislava Medical Journal [online], 2025, 126(9.0), 2233-2240.
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Cancer stem cells: Masters of all traits. Leck Lionel Y.W., Abd El-Aziz Yomna S., McKelvey Kelly J., Park Kyung Chan, Sahni Sumit, Lane Darius J.R., Skoda Jan a Jansson Patric J.. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease [online], 2025, 1871(3.0), 167549.
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Improving mitochondria-associated endoplasmic reticulum membranes integrity as converging therapeutic strategy for rare neurodegenerative diseases and cancer. Cagalinec Michal, Mohd Adnan, Borecka Silvia, Bultynck Geert, Choubey Vinay, Yanovsky-Dagan Shira, Ezer Shlomit, Gasperikova Daniela, Harel Tamar, Jurkovicova Dana, Kaasik Allen, Liévens Jean-Charles, Maurice Tangui, Peviani Marco, Richard Elodie Marie, Skoda Jan, Skopkova Martina, Tarot Pauline, Van Gorp Robbe, Zvejniece Liga a Delprat Benjamin. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research [online], 2025, 1872(5.0), 119954.
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Biomarkers and therapeutic targets in giant cell tumor of bone: A comprehensive review. Knechtova Veronika, Mahdal Michal, Zambo Iva Staniczkova, Skoda Jan a Neradil Jakub. Bone [online], 2025, 199, 117566.
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Improving neuroblastoma therapy with a new p53 family-activating agent. Almeida Joana, Resende Diana I.S.P., Silva Rita, Villasante Aranzazu, Murphy Catherine, Zingales Veronica, Palmeira Andreia, Škoda Jan, Broso Francesca, Vadivellu Aiswariya, Oliveira Paula, Reis Salette, Nunes Cláudia, Loh Amos Hong Pheng, Ferreira Joana M., Martins Eduarda P., Costa Bruno M., Inga Alberto, Samitier Josep, Sousa Emília a Saraiva Lucília. European Journal of Pharmacology [online], 2025, 1007, 178295.
doi: https://doi.org/10.1016/j.ejphar.2025.178295. PMID: 38826717
Carfilzomib-specific proteasome β5/β2 inhibition drives cardiotoxicity via remodeling of protein homeostasis and the renin-angiotensin-system. Mendez-Lopez Max, Besse Andrej, Zuppinger Christian, Perez-Shibayama Christian, Gil-Cruz Cristina, Florea Bogdan I., De Martin Angelina, Lütge Mechthild, Beckerova Deborah, Klimovic Simon, Zhou Xiang, Rasche Leo, Pribyl Jan, Rotrekl Vladimir, Ludewig Burkhard, Overkleeft Herman S., Besse Lenka a Driessen Christoph. iScience [online], 2025, 28(9.0), 113228.
doi: https://doi.org/10.1016/j.isci.2025.113228. PMID: 40894880
In-cell NMR spectroscopy of nucleic acids: Basic concepts, practical aspects, and applications. Foldynova-Trantirkova Silvie, Harnos Jakub, Rynes Jan, Zlinska Vladimira a Trantirek Lukas. Progress in Nuclear Magnetic Resonance Spectroscopy [online], 2025, 101560.
doi: https://doi.org/10.1016/j.pnmrs.2025.101560. PMID: 40912878
ATM aberrations in chronic lymphocytic leukemia: del(11q) rather than ATM mutations is an adverse-prognostic biomarker. Thorvaldsdottir Birna, Mansouri Larry, Sutton Lesley-Ann, Nadeu Ferran, Meggendorfer Manja, Parker Helen, Brieghel Christian, Laidou Stamatia, Moia Riccardo, Rossi Davide, Kotaskova Jana, Delgado Julio, Rodríguez-Vicente Ana E., Benito Rocío, Rigolin Gian Matteo, Bonfiglio Silvia, Scarfò Lydia, Mattsson Mattias, Davis Zadie, Baliakas Panagiotis, Rapado Inmaculada, Miras Fatima, Martinez-Lopez Joaquín, De La Serna Javier, Hernández Rivas Jesús María, Larráyoz María José, Calasanz María José, Smedby Karin E., Espinet Blanca, Puiggros Anna, Bullinger Lars, Bosch Francesc, Tazón-Vega Bárbara, Baran-Marszak Fanny, Oscier David, Nguyen-Khac Florence, Zenz Thorsten, Terol Maria Jose, Cuneo Antonio, Hernández-Sánchez María, Pospisilova Sarka, Gaidano Gianluca, Niemann Carsten U., Campo Elias, Strefford Jonathan C., Ghia Paolo, Stamatopoulos Kostas a Rosenquist Richard. Leukemia [online], 2025, 39(7.0), 1650-1660.
doi: https://doi.org/10.1038/s41375-025-02615-5. PMID: 40275070
Disease-specific U1 spliceosomal RNA mutations in mature B-cell neoplasms. Nadeu Ferran, Shuai Shimin, Clot Guillem, Hilton Laura K., Diaz-Navarro Ander, Martín Silvia, Royo Romina, Baumann Tycho, Kulis Marta, López-Oreja Irene, Cossio Manuel, Lu Junyan, Ljungström Viktor, Young Emma, Plevova Karla, Knisbacher Binyamin A., Lin Ziao, Hahn Cynthia K., Bousquets Pablo, Alcoceba Miguel, González Marcos, Colado Enrique, Payer Ángel R., Aymerich Marta, Terol María J., Rivas-Delgado Alfredo, Enjuanes Anna, Ruiz-Gaspà Sílvia, Chatzikonstantinou Thomas, Hägerstrand Daniel, Jylhä Cecilia, Skaftason Aron, Mansouri Larry, Stranska Kamila, Doubek Michael, Van Gastel-Mol Ellen J., Davis Zadie, Walewska Renata, Scarfò Lydia, Trentin Livio, Visentin Andrea, Parikh Sameer A., Rabe Kari G., Moia Riccardo, Armand Marine, Rossi Davide, Davi Frederic, Gaidano Gianluca, Kay Neil E., Shanafelt Tait D., Ghia Paolo, Oscier David, Langerak Anton W., Beà Sílvia, López-Guillermo Armando, Neuberg Donna, Wu Catherine J., Getz Gad, Pospisilova Sarka, Stamatopoulos Kostas, Rosenquist Richard, Huber Wolfgang, Zenz Thorsten, Colomer Dolors, Martín-Subero José I., Delgado Julio, Morin Ryan D., Stein Lincoln D., Puente Xose S. a Campo Elías. Leukemia [online], 2025, 39(9.0), 2076-2086.
doi: https://doi.org/10.1038/s41375-025-02667-7. PMID: 40588565
Targeting proteostasis in multiple myeloma through inhibition of LTK. Våtsveen Thea Kristin, Giliberto Mariaserena, Bjornsdottir Valgerdur, Centonze Federica, Besse Andrej, Frey Yannick, Skånland Sigrid S., Tveita Anders, Alirezaylavasani Amin, Imbery John Franklin, Misund Kristine, Reiterer Veronika, Zahoor Muhammad, Driessen Christoph, Besse Lenka, Tasken Kjetil, Schjesvold Fredrik H., Farhan Hesso a Munthe Ludvig A.. Leukemia [online], 2025, 39(9.0), 2237-2245.
doi: https://doi.org/10.1038/s41375-025-02682-8. PMID: 40634511
Uncovering pre-cytokinetic block in cancer cells under shear stress using a disturbed flow-generating device. Beresova Lucie, Vitecek Jan, Protivánková Iva, Dudka Michal, Chroma Katarina, Skrott Zdenek, Buchtova Tereza, Poláková Kamila, Novotny Jan, Novakova Ludmila, Bartek Jiri a Mistrik Martin. Scientific Reports [online], 2025, 15(1.0), 6457.
doi: https://doi.org/10.1038/s41598-024-83058-3. PMID: 39987149
crossNN is an explainable framework for cross-platform DNA methylation-based classification of tumors. Yuan Dongsheng, Jugas Robin, Pokorna Petra, Sterba Jaroslav, Slaby Ondrej, Schmid Simone, Siewert Christin, Osberg Brendan, Capper David, Halldorsson Skarphedinn, Vik-Mo Einar O., Zeiner Pia S., Weber Katharina J., Harter Patrick N., Thomas Christian, Albers Anne, Rechsteiner Markus, Reimann Regina, Appelt Anton, Schüller Ulrich, Jabareen Nabil, Mackowiak Sebastian, Ishaque Naveed, Eils Roland, Lukassen Sören a Euskirchen Philipp. Nature Cancer [online], 2025, 6(7.0), 1283-1294.
doi: https://doi.org/10.1038/s43018-025-00976-5. PMID: 40481322
FGFR2 residence in primary cilia is necessary for epithelial cell signaling. Nita Alexandru, Abraham Sara P., Elrefaay Eman R., Fafilek Bohumil, Cizkova Eliska, Ursachi Vlad Constantin, Gudernova Iva, Koudelka Adolf, Dudeja Pooja, Gregor Tomas, Feketova Zuzana, Rico Gustavo, Svozilova Katerina, Celiker Canan, Czyrek Aleksandra A., Barta Tomas, Trantirek Lukas, Wiedlocha Antoni, Krejci Pavel a Bosakova Michaela. Journal of Cell Biology [online], 2025, 224(7.0), e202311030.
doi: https://doi.org/10.1083/jcb.202311030. PMID: 40257378
Incidental germline findings during comprehensive genomic profiling of pancreatic and colorectal cancer: single-centre, molecular tumour board experience. Eid Michal, Trizuljak Jakub, Taslerova Renata, Gryc Martin, Vlazny Jakub, Vilmanova Sara, Jelinkova Martina, Homolova Alena, Tucek Stepan, Hlavsa Jan, Grolich Tomas, Kala Zdenek, Kral Zdenek a Slaby Ondrej. Mutagenesis [online], 2025, 40(1.0), 20-29.
doi: https://doi.org/10.1093/mutage/geae014. PMID: 38773787
Sinonasal adenosquamous carcinomas arising in seromucinous hamartoma or respiratory epithelial adenomatoid hamartoma with atypical features: Report of five detailed clinicopathological and molecular characterisation of rare entity. Bradová Martina, Costes‐Martineau Valerie, Laco Jan, Vaněček Tomáš, Grossmann Petr, Němcová Jana, Pavlovský Zdeněk, Skálová Alena a Michal Michal. Histopathology [online], 2025, 86(4.0), 585-602.
doi: https://doi.org/10.1111/his.15369. PMID: 39564605
2024
Multistep allelic conversion in mouse pre-implantation embryos by AAV vectors. Nickl Petr, Jenickova Irena, Elias Jan, Kasparek Petr, Barinka Cyril, Kopkanova Jana a Sedlacek Radislav. Scientific Reports [online], 2024, 14(1), 20160.
doi: https://doi.org/10.1038/s41598-024-70853-1. PMID: 39215103
Achondroplasia: aligning mouse model with human clinical studies shows crucial importance of immediate postnatal start of the therapy. Rico-Llanos Gustavo, Spoutil Frantisek, Blahova Eva, Koudelka Adolf, Prochazkova Michaela, Czyrek Aleksandra, Fafilek Bohumil, Prochazka Jan, Gonzalez Lopez Marcos, Krivanek Jan, Sedlacek Radislav, Krakow Deborah, Nonaka Yosuke, Nakamura Yoshikazu a Krejci Pavel. Journal of Bone and Mineral Research [online], 2024, 39(12), 1783-1792.
doi: https://doi.org/10.1093/jbmr/zjae173. PMID: 39423254
In vitro culture of leukemic cells in collagen scaffolds and carboxymethyl cellulose-polyethylene glycol gel. Svozilova Hana, Vojtova Lucy, Matulova Jana, Bruknerova Jana, Polakova Veronika, Radova Lenka, Doubek Michael, Plevova Karla a Pospisilova Sarka. PeerJ [online], 2024, 12, e18637.
doi: https://doi.org/10.7717/peerj.18637. PMID: 39655330
Genetic Predisposition to Male Breast Cancer. Janatová Markéta, Borecká Marianna, Zemánková Petra, Matějková Kateřina, Nehasil Petr, Černá Leona, Černá Marta, Dušková Petra, Doležalová Taťána, Foretová Lenka, Havránek Ondřej, Házová Jana, Horáčková Klára, Hovhannisyan Milena, Hrušková Lucie, Chvojka Štěpán, Janíková Mária, Kalousová Marta, Kosařová Marcela, Koudová Monika, Krhutová Veronika, Krulišová Veronika, Macháčková Eva, Michalovská Renáta, Němcová Barbora, Novotný Jan, Šafaříková Markéta, Šťastná Barbora, Stránecký Viktor, Šubrt Ivan, Tavandzis Spiros, Vlčková Zdeňka, Vočka Michal, Vrtěl Radek, Zima Tomáš, Soukupová Jana, Kleiblová Petra a Kleibl Zdeněk. Folia Biologica [online], 2024, 70(5-6), 274-284.
doi: https://doi.org/10.14712/fb2024070050274. PMID: 39889220
Perturbations in eIF3 subunit stoichiometry alter expression of ribosomal proteins and key components of the MAPK signaling pathways. Herrmannová Anna, Jelínek Jan, Pospíšilová Klára, Kerényi Farkas, Vomastek Tomáš, Watt Kathleen, Brábek Jan, Mohammad Mahabub Pasha, Wagner Susan, Topisirovic Ivan a Valášek Leoš Shivaya. eLife [online], 2024, 13, RP95846.
doi: https://doi.org/10.7554/eLife.95846. PMID: 39495207
P26.11.B PIWIL2 AS A POTENTIAL REGULATOR OF STEM-CELL PHENOTYPE IN GLIOBLASTOMA. Garcia-Borja E, Mateu R, Siegl F, Šána J, Šedo A a Bušek P. Neuro-Oncology [online], 2024, 26(Supplement_5), v135-v135.
doi: https://doi.org/10.1093/neuonc/noae144.459. PMID: 33061623
Comparison of Two Chelator Scaffolds as Basis for Cholecystokinin-2 Receptor Targeting Bimodal Imaging Probes. Gariglio Giacomo, Bendova Katerina, Hermann Martin, Olafsdottir Asta, Sosabowski Jane K., Petrik Milos, Von Guggenberg Elisabeth a Decristoforo Clemens. Pharmaceuticals [online], 2024, 17(12.0), 1569.
doi: https://doi.org/10.3390/ph17121569. PMID: 39770411
Synthesis and Biological Evaluation of Oxindole Sulfonamide Derivatives as Bruton's Tyrosine Kinase Inhibitors**. Koraboina Chandra Prakash, Maddipati Venkatanarayana Chowdary, Annadurai Narendran, Gurská Soňa, Džubák Petr, Hajdúch Marián, Das Viswanath a Gundla Rambabu. ChemMedChem [online], 2024, 19(1.0), e202300511.
doi: https://doi.org/10.1002/cmdc.202300511. PMID: 37916435
Dysregulation of the p53 pathway provides a therapeutic target in aggressive pediatric sarcomas with stem-like traits. Curylova Lucie, Staniczkova Zambo Iva, Neradil Jakub, Kyr Michal, Jurackova Nicola, Pavlova Sarka, Polaskova Kristyna, Mudry Peter, Sterba Jaroslav, Veselska Renata a Skoda Jan. Cellular Oncology [online], 2024, 47(6.0), 2317-2334.
doi: https://doi.org/10.1007/s13402-024-01020-x. PMID: 39630408
Splice variants of CK1α and CK1α-like: Comparative analysis of subcellular localization, kinase activity, and function in the Wnt signaling pathway. Gybeľ Tomáš, Čada Štěpán, Klementová Darja, Schwalm Martin P., Berger Benedict-Tilman, Šebesta Marek, Knapp Stefan a Bryja Vítězslav. Journal of Biological Chemistry [online], 2024, 300(7.0), 107407.
doi: https://doi.org/10.1016/j.jbc.2024.107407. PMID: 38796065
Bio-responsive polymers for dual 31P/19F-magnetic resonance to detect reactive oxygen species in vivo. Jirát-Ziółkowska Natalia, Sulková Kateřina, Kracíková Lucie, Androvič Ladislav, Havliček Dominik, Laga Richard a Jirák Daniel. Communications Materials [online], 2024, 5(1.0), 178.
doi: https://doi.org/10.1038/s43246-024-00623-z. PMID: 37880705
Multicomponent Reactions: A Promising Approach to Isotope Labeling. Xiao Siyu, Conte Antonio, Cornelissen Bart T., Domling Alexander a Elsinga Philip H.. Synlett [online], 2024, 35(19.0), 2174-2190.
doi: https://doi.org/10.1055/a-2331-6399. PMID: 3785596
Synthesis and migrastatic activity of cytochalasin analogues lacking a macrocyclic moiety. Formánek Bedřich, Dupommier Dorian, Volfová Tereza, Rimpelová Silvie, Škarková Aneta, Herciková Jana, Rösel Daniel, Brábek Jan a Perlíková Pavla. RSC Medicinal Chemistry [online], 2024, 15(1.0), 322-343.
doi: https://doi.org/10.1039/D3MD00535F. PMID: 38283219
Frequencies of chromosomal aberrations and related biochemical parameters in welders. Pavel Vodicka, Ludovit Musak, Marian Grendar, Jela Valachova, Ludmila Vodickova a Erika Halasova. Mutation Research - Genetic Toxicology and Environmental Mutagenesis [online], 2024, 898, 503806.
doi: https://doi.org/10.1016/j.mrgentox.2024.503806. PMID: 39147451
Genome-wide meta-analyses of restless legs syndrome yield insights into genetic architecture, disease biology and risk prediction. Schormair Barbara, Zhao Chen, Bell Steven, Didriksen Maria, Nawaz Muhammad S., Schandra Nathalie, Stefani Ambra, Högl Birgit, Dauvilliers Yves, Bachmann Cornelius G., Kemlink David, Sonka Karel, Paulus Walter, Trenkwalder Claudia, Oertel Wolfgang H., Hornyak Magdolna, Teder-Laving Maris, Metspalu Andres, Hadjigeorgiou Georgios M., Polo Olli, Fietze Ingo, Ross Owen A., Wszolek Zbigniew K., Ibrahim Abubaker, Bergmann Melanie, Kittke Volker, Harrer Philip, Dowsett Joseph, Chenini Sofiene, Ostrowski Sisse Rye, Sørensen Erik, Erikstrup Christian, Pedersen Ole B., Topholm Bruun Mie, Nielsen Kaspar R., Butterworth Adam S., Soranzo Nicole, Ouwehand Willem H., Roberts David J., Danesh John, Burchell Brendan, Furlotte Nicholas A., Nandakumar Priyanka, 23andMe Research Team, D.E.S.I.R. study group, Bonnefond Amélie, Potier Louis, Earley Christopher J., Ondo William G., Xiong Lan, Desautels Alex, Perola Markus, Vodicka Pavel, Dina Christian, Stoll Monika, Franke Andre, Lieb Wolfgang, Stewart Alexandre F. R., Shah Svati H., Gieger Christian, Peters Annette, Rye David B., Rouleau Guy A., Berger Klaus, Stefansson Hreinn, Ullum Henrik, Stefansson Kari, Hinds David A., Di Angelantonio Emanuele, Oexle Konrad a Winkelmann Juliane. Nature Genetics [online], 2024, 56(6), 1090-1099.
doi: https://doi.org/10.1038/s41588-024-01763-1. PMID: 38839884
TBK1-associated adapters TANK and AZI2 protect mice against TNF-induced cell death and severe autoinflammatory diseases. Ujevic Andrea, Knizkova Daniela, Synackova Alzbeta, Pribikova Michaela, Trivic Tijana, Dalinskaya Anna, Drobek Ales, Niederlova Veronika, Paprckova Darina, De Guia Roldan, Kasparek Petr, Prochazka Jan, Labaj Juraj, Fedosieieva Olha, Roeck Bernhard Florian, Mihola Ondrej, Trachtulec Zdenek, Sedlacek Radislav, Stepanek Ondrej a Draber Peter. Nature Communications [online], 2024, 15(1), 10013.
doi: https://doi.org/10.1038/s41467-024-54399-4. PMID: 39562788
The guidelines for clinical practice for carriers of germline mutations in hereditary breast, ovarian, prostate, and pancreatic cancer predisposition genes BRCA1, BRCA2, PALB2, ATM, and CHEK2 (4.2024). Kleiblová Petra, Novotný Jan, Cibula David, Curtisová Václava, Dubová Olga, Foretová Lenka, Germanová Anna, Janatová Markéta, Havránek Ondřej, Hojsáková Markéta, Hudcová Markéta, Koudová Monika, Krutílková Věra, Palácová Markéta, Paulich Sviatlana, Petráková Katarína, Presl Jiří, Puchmajerová Alena, Soukupová Jana, Šenkeříková Mária, Šimková Zuzana, Štěpánková Helena, Šubrt Ivan, Tachecí Ija, Tesner Pavel, Urban Ondřej, Veselá Kamila, Vilímová Šárka, Vlčková Zdeňka, Vočka Michal, Weinberger Vít, Zikán Michal, Zimovjanová Martina a Kleibl Zdeněk. Klinicka onkologie [online], 2024, 37(4).
doi: https://doi.org/10.48095/ccko2024292. PMID: 39174333
The guidelines for clinical practice for carriers of germline mutations in the Lynch syndrome predisposition genes MLH1, MSH2, MSH6, PMS2 and large deletions of EPCAM (4.2024). Novotný Jan, Cibula David, Curtisová Václava, Dubová Olga, Foretová Lenka, Germanová Anna, Janatová Markéta, Havránek Ondřej, Hojsáková Markéta, Hudcová Markéta, Koudová Monika, Krutílková Věra, Palácová Markéta, Paulich Sviatlana, Petráková Katarína, Presl Jří, Puchmajerová Alena, Soukupová Jana, Šenkeříková Mária, Šimková Zuzana, Štěpánková Helena, Šubrt Ivan, Tachecí Ilja, Tesner Pavel, Urban Ondřej, Veselá Kamila, Vilímová Šárka, Vlčková Zdeňka, Vočka Michal, Weinberger Vít, Zikán Michal, Zimovjanová Martina, Kleibl Zdeněk a Kleiblová Petra. Klinicka onkologie [online], 2024, 37(5).
doi: https://doi.org/10.48095/ccko2024384. PMID: 39516038
Antigen-independent, autonomous B cell receptor signaling drives activated B cell DLBCL. Eken Janneke A., Koning Marvyn T., Kupcova Kristyna, Sepúlveda Yáñez Julieta H., De Groen Ruben A.L., Quinten Edwin, Janssen Jurriaan, Van Bergen Cornelis A.M., Vermaat Joost S.P., Cleven Arjen, Navarrete Marcelo A., Ylstra Bauke, De Jong Daphne, Havranek Ondrej, Jumaa Hassan a Veelken Hendrik. Journal of Experimental Medicine [online], 2024, 221(5), e20230941.
doi: https://doi.org/10.1084/jem.20230941. PMID: 38512136
Immune Checkpoints and Their Inhibition in T-Cell Lymphomas. Seňavová Jana, Rajmonová Anežka, Heřman Václav, Jura Filip, Veľasová Adriana, Hamová Iva, Tkachenko Anton, Kupcová Kristýna a Havránek Ondřej. Folia Biologica [online], 2024, 70(3), 123-151.
doi: https://doi.org/10.14712/fb2024070030123. PMID: 396441091
Multistep allelic conversion in mouse pre-implantation embryos by AAV vectors. Nickl Petr, Jenickova Irena, Elias Jan, Kasparek Petr, Barinka Cyril, Kopkanova Jana a Sedlacek Radislav. Scientific Reports [online], 2024, 14(1), 20160.
doi: https://doi.org/10.1038/s41598-024-70853-1. PMID: 39215103
Investigation of the potential effects of estrogen receptor modulators on immune checkpoint molecules. Abramenko, Nikita, Fréderic Vellieux, Kateřina Veselá, Zdeněk Kejík, Jan Hajduch, Michal Masařík, Petr Babula, David Hoskovec, Karel Pacák, Pavel Martásek, Karel Smetana a Milan Jakubek. Scientific Reports [online], 2024, 14(1), 3043.
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Mechanism of BCDX2-mediated RAD51 nucleation on short ssDNA stretches and fork DNA. Akita, Masaki, Paul Girvan, Mario Spirek, Jiri Novacek, David Rueda, Zbynek Prokop A Lumir Krejci. Nucleic Acids Research [online], 2024, 52(19), 11738–11752.
doi: 10.1093/nar/gkae770
Topological stress triggers persistent DNA lesions in ribosomal DNA with ensuing formation of PML-nucleolar compartment. Alexandra Urbancokova, Terezie Hornofova, Josef Novak, Sarka Andrs Salajkova, Sona Stemberkova Hubackova, Alena Uvizl, Tereza Buchtova Martin Mistrik, Brian McStay, Zdenek Hodny, Jiri Bartek a Pavla Vasicova. Elife, 2024 Oct 10:12:RP91304.
doi: 10.7554/eLife.91304.3.sa0
Chemical modification of bradykinin-polymer conjugates for optimum delivery of nanomedicines to tumors. Appiah, Enoch, Hideaki Nakamura, Anthony Assumang, Tomáš Etrych a Mamoru Haratake. Nanomedicine: Nanotechnology, Biology and Medicine [online], 2024, 57, 102744.
doi: 10.1016/j.nano.2024.102744
FAM110A promotes mitotic spindle formation by linking microtubules with actin cytoskeleton. Aquino-Perez, Cecilia, Mahira Safaralizade, Roman Podhajecky, Hong Wang, Zdenek Lansky, Robert Grosse A Libor Macurek. Proceedings of the National Academy of Sciences [online], 2024, 121(29), e2321647121.
Extensive targeting of chemical space at the prime side of ketoamide inhibitors of rhomboid proteases by branched substituents empowers their selectivity and potency. Bach, Kathrin, Jan Dohnálek, Jana Škerlová, Ján Kuzmík, Edita Poláchová, Stancho Stanchev, Pavel Majer, Jindřich Fanfrlík, Adam Pecina, Jan Řezáč, Martin Lepšík, Valentin Borshchevskiy, Vitaly Polovinkin A Kvido Strisovsky. European Journal of Medicinal Chemistry [online], 2024, 275, 116606.
doi: 10.1016/j.ejmech.2024.116606
Advanced technologies towards improved HPV diagnostics. Bartosik, Martin, Ludmila Moranova, Nasim Izadi, Johana Strmiskova, Ravery Sebuyoya, Jitka Holcakova a Roman Hrstka. Journal of Medical Virology [online], 2024, 96(2), e29409.
doi: 10.1002/jmv.29409
HIV-protease inhibitors potentiate the activity of carfilzomib in triple-negative breast cancer. Besse, Andrej, Lenka Sedlarikova, Lorina Buechler, Marianne Kraus, Chieh-Hsiang Yang, Nicol Strakova, Karel Soucek, Jiri Navratil, Marek Svoboda, Alana L. Welm, Markus Joerger, Christoph Driessen a Lenka Besse. British Journal of Cancer [online], 2024, 131(5), 918–930.
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Impact of PIK3CA gain and PTEN loss on mantle cell lymphoma biology and sensitivity to targeted therapies. Bettazova, Nardjas, Jana Senavova, Kristyna Kupcova, Dana Sovilj, Anezka Rajmonova, Ladislav Andera, Karla Svobodova, Adela Berkova, Zuzana Zemanova, Lenka Daumova, Vaclav Herman, Alexandra Dolníkova, R. Eric Davis, Marek Trneny, Pavel Klener a Ondrej Havranek. Blood Advances [online], 2024, 8(20), 5279–5289.
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CD20 expression regulates CD37 levels in B-cell lymphoma – implications for immunotherapies. Bobrowicz, Malgorzata, Aleksandra Kusowska, Marta Krawczyk, Andriy Zhylko, Christopher Forcados, Aleksander Slusarczyk, Joanna Barankiewicz, Joanna Domagala, Matylda Kubacz, Michal Šmída, Lenka Dostalova, Katsiaryna Marhelava, Klaudyna Fidyt, Monika Pepek, Iwona Baranowska, Anna Szumera-Cieckiewicz, Else Marit Inderberg, Sébastien Wälchli, Monika Granica, Agnieszka Graczyk-Jarzynka, Martyna Majchrzak, Marcin Poreba, Carina Lynn Gehlert, Matthias Peipp, Malgorzata Firczuk, Monika Prochorec-Sobieszek a Magdalena Winiarska. OncoImmunology [online], 2024, 13(1), 2362454.
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In vivo interaction screening reveals liver-derived constraints to metastasis. Borrelli, Costanza, Morgan Roberts, Davide Eletto, Marie-Didiée Hussherr, Hassan Fazilaty, Tomas Valenta, Atefeh Lafzi, Jonas A. Kretz, Elena Guido Vinzoni, Andromachi Karakatsani, Srivathsan Adivarahan, Ardian Mannhart, Shoichiro Kimura, Ab Meijs, Farah Baccouche Mhamedi, Ilhan E. Acar, Kristina Handler, Xenia Ficht, Randall J. Platt, Salvatore Piscuoglio a Andreas E. Moor. Nature [online], 2024, 632(8024), 411–418.
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Iron chelators as mitophagy agents: Potential and limitations. Brogyanyi, Tereza, Zdeněk Kejík, Kateřina Veselá, Petr Dytrych, David Hoskovec, Michal Masařik, Petr Babula, Robert Kaplánek, Tomáš Přibyl, Jaroslav Zelenka, Tomáš Ruml, Martin Vokurka, Pavel Martásek a Milan Jakubek. Biomedicine & Pharmacotherapy [online], 2024, 179, 117407.
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Imatinib therapy of chronic myeloid leukemia significantly reduces carnitine cell intake, resulting in adverse events. Burda, Pavel, Alzbeta Hlavackova, Vendula Polivkova, Nikola Curik, Adam Laznicka, Jitka Krizkova, Jiri Suttnar, Pavel Klener a Katerina Machova Polakova. Molecular Metabolism [online], 2024, 88, 102016.
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The non-canonical BAF chromatin remodeling complex is a novel target of spliceosome dysregulation in SF3B1-mutated chronic lymphocytic leukemia. Hägerstrand, Daniel, Blaž Oder, Diego Cortese, Ying Qu, Amrei Binzer-Panchal, Cecilia Österholm, Teresa Del Peso Santos, Leily Rabbani, Hassan Foroughi Asl, Aron Skaftason, Viktor Ljungström, August Lundholm, Maria Koutroumani, Zahra Haider, Cecilia Jylhä, John Mollstedt, Larry Mansouri, Karla Plevova, Andreas Agathangelidis, Lydia Scarfò, Marine Armand, Alice F. Muggen, Neil E. Kay, Tait Shanafelt, Davide Rossi, Lukas M. Orre, Sarka Pospisilova, Konstantin Barylyuk, Frederic Davi, Mattias Vesterlund, Anton W. Langerak, Janne Lehtiö, Paolo Ghia, Kostas Stamatopoulos, Lesley-Ann Sutton a Richard Rosenquist. Leukemia [online], 2024, 38(11), 2429–2442.
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Stromal cells engineered to express T cell factors induce robust CLL cell proliferation in vitro and in PDX co-transplantations allowing the identification of RAF inhibitors as anti-proliferative drugs. Hoferkova, Eva, Vaclav Seda, Sona Kadakova, Jan Verner, Tomas Loja, Kvetoslava Matulova, Hana Skuhrova Francova, Eva Ondrouskova, Daniel Filip, Nicolas Blavet, Miroslav Boudny, Gabriela Mladonicka Pavlasova, Josef Vecera, Laura Ondrisova, Petra Pavelkova, Krystof Hlavac, Lenka Kostalova, Androniki Michaelou, Sarka Pospisilova, Jana Dorazilova, Vaclav Chochola, Josef Jaros, Michael Doubek, Marie Jarosova, Ales Hampl, Lucy Vojtova, Leos Kren, Jiri Mayer a Marek Mraz. Leukemia [online], 2024, 38(8), 1699–1711.
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Therapeutic strategies and treatment sequencing in patients with chronic lymphocytic leukemia: An international study of ERIC, the European Research Initiative on CLL. Chatzikonstantinou, Thomas, Lydia Scarfò, Eva Minga, Georgios Karakatsoulis, Dimitra Chamou, Jana Kotaskova, Gloria Iacoboni, Christos Demosthenous, Elisa Albi, Miguel Alcoceba, Salem Al‐Shemari, Thérèse Aurran‐Schleinitz, Francesca Bacchiarri, Sofia Chatzileontiadou, Rosa Collado, Zadie Davis, Marcos Daniel De Deus Santos, Maria Dimou, Elena Dmitrieva, David Donaldson, Gimena Dos Santos, Barbara Dreta, Maria Efstathopoulou, Shaimaa El‐Ashwah, Alicia Enrico, Andrzej Frygier, Sara Galimberti, Andrea Galitzia, Eva Gimeno, Valerio Guarente, Romain Guieze, Sean Harrop, Eleftheria Hatzimichael, Yair Herishanu, José‐Ángel Hernández‐Rivas, Ozren Jaksic, Elżbieta Kalicińska, Kamel Laribi, Volkan Karakus, Arnon P. Kater, Bonnie Kho, Maria Kislova, Εliana Konstantinou, Maya Koren‐Michowitz, Ioannis Kotsianidis, Zuzana Kubova, Jorge Labrador, Deepesh Lad, Luca Laurenti, Thomas Longval, Alberto Lopez‐Garcia, Juan Marquet, Stanislava Maslejova, Carlota Mayor‐Bastida, Biljana Mihaljevic, Ivana Milosevic, Fatima Miras, Riccardo Moia, Marta Morawska, Uttam K. Nath, Almudena Navarro‐Bailón, Jacopo Olivieri, Irina Panovska‐Stavridis, Maria Papaioannou, Cheyenne Pierie, Anna Puiggros, Gianluigi Reda, Gian M. Rigolin, Rosa Ruchlemer, Mattia Schipani, Annett Schiwitza, Yandong Shen, Tereza Shokralla, Martin Simkovic, Svetlana Smirnova, Dina S. A. Soliman, Stephan Stilgenbauer, Tamar Tadmor, Kristina Tomic, Eric Tse, Theodoros Vassilakopoulos, Andrea Visentin, Candida Vitale, George Vrachiolias, Vojin Vukovic, Renata Walewska, Zhenshu Xu, Munci Yagci, Lucrecia Yañez, Mohamed Yassin, Jana Zuchnicka, David Oscier, Alessandro Gozzetti, Panagiotis Panagiotidis, Francesc Bosch, Paolo Sportoletti, Blanca Espinet, Gerassimos A. Pangalis, Viola M. Popov, Stephen Mulligan, Maria Angelopoulou, Fatih Demirkan, Tomas Papajík, Bella Biderman, Roberta Murru, Marta Coscia, Constantine Tam, Antonio Cuneo, Gianluca Gaidano, Rainer Claus, Niki Stavroyianni, Livio Trentin, Darko Antic, Lukas Smolej, Olga B. Kalashnikova, Mark Catherwood, Martin Spacek, Sarka Pospisilova, Michael Doubek, Eugene Nikitin, Anastasia Chatzidimitriou, Paolo Ghia a Kostas Stamatopoulos. HemaSphere [online], 2024, 8(9), e70004.
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LAMP‐based electrochemical platform for monitoring HPV genome integration at the mRNA level associated with higher risk of cervical cancer progression. Izadi, Nasim, Johana Strmiskova, Milan Anton, Jitka Hausnerova a Martin Bartosik. Journal of Medical Virology [online], 2024, 96(10), e70008.
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Molecular Screening in Anaplastic Lymphoma Kinase–Positive Anaplastic Large Cell Lymphoma: Anaplastic Lymphoma Kinase Analysis, Next-Generation Sequencing Fusion Gene Detection, and T-Cell Receptor Immunoprofiling. Kalinova, Marketa, Marcela Mrhalova, Edita Kabickova, Michael Svaton, Aneta Skotnicova, Zuzana Prouzova, Zdenka Krenova, Alexandra Kolenova, Martina Divoka, Eva Fronkova a Roman Kodet. Modern Pathology [online], 2024, 37(3), 100428.
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Tertiary lymphoid structures and B cells determine clinically relevant T cell phenotypes in ovarian cancer. Kasikova, Lenka, Jana Rakova, Michal Hensler, Tereza Lanickova, Jana Tomankova, Josef Pasulka, Jana Drozenova, Katerina Mojzisova, Anna Fialova, Sarka Vosahlikova, Jan Laco, Ales Ryska, Pavel Dundr, Roman Kocian, Tomas Brtnicky, Petr Skapa, Linda Capkova, Marek Kovar, Jan Prochazka, Ivan Praznovec, Vladimir Koblizek, Alice Taskova, Hisashi Tanaka, Robert Lischke, Fernando Casas Mendez, Jiri Vachtenheim, Viola Heinzelmann-Schwarz, Francis Jacob, Iain A. Mcneish, Michal J. Halaska, Lukas Rob, David Cibula, Sandra Orsulic, Lorenzo Galluzzi, Radek Spisek a Jitka Fucikova. Nature Communications [online], 2024, 15(1), 2528.
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Novel triterpenoid pyrones, phthalimides and phthalates are selectively cytotoxic in CCRF-CEM cancer cells – Synthesis, potency, and mitochondrial mechanism of action. Kazakova, Anna, Ivo Frydrych, Nikola Jakubcová, Jan Pokorný, Barbora Lišková, Soňa Gurská, Petr Džubák, Marián Hajdúch a Milan Urban. European Journal of Medicinal Chemistry [online], 2024, 269, 116336.
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Cyanine dyes in the mitochondria-targeting photodynamic and photothermal therapy. Kejík, Zdeněk, Jan Hajduch, Nikita Abramenko, Frédéric Vellieux, Kateřina Veselá, Jindřiška Leischner Fialová, Kateřina Petrláková, Kateřina Kučnirová, Robert Kaplánek, Ameneh Tatar, Markéta Skaličková, Michal Masařík, Petr Babula, Petr Dytrych, David Hoskovec, Pavel Martásek a Milan Jakubek. Communications Chemistry [online], 2024, 7(1), 180.
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A computational workflow for analysis of missense mutations in precision oncology. Khan, Rayyan Tariq, Petra Pokorna, Jan Stourac, Simeon Borko, Ihor Arefiev, Joan Planas-Iglesias, Adam Dobias, Gaspar Pinto, Veronika Szotkowska, Jaroslav Sterba, Ondrej Slaby, Jiri Damborsky, Stanislav Mazurenko a David Bednar. Journal of Cheminformatics [online], 2024, 16(1), 86.
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A deep intronic recurrent CHEK2 variant c.1009-118_1009-87delinsC affects pre-mRNA splicing and contributes to hereditary breast cancer predisposition. Zemankova, Petra, Marta Cerna, Klara Horackova, Corinna Ernst, Jana Soukupova, Marianna Borecka, Britta Blümcke, Leona Cerna, Monika Cerna, Vaclava Curtisova, Tatana Dolezalova, Petra Duskova, Lenka Dvorakova, Lenka Foretova, Ondrej Havranek, Jan Hauke, Eric Hahnen, Miloslava Hodulova, Milena Hovhannisyan, Lucie Hruskova, Marketa Janatova, Maria Janikova, Sandra Jelinkova, Pavel Just, Marcela Kosarova, Monika Koudova, Vera Krutilkova, Eva Machackova, Katerina Matejkova, Renata Michalovska, Adela Misove, Petr Nehasil, Barbora Nemcova, Jan Novotny, Ales Panczak, Pavel Pesek, Ondrej Scheinost, Drahomira Springer, Barbora Stastna, Viktor Stranecky, Ivan Subrt, Spiros Tavandzis, Eva Tureckova, Kamila Vesela, Zdenka Vlckova, Michal Vocka, Barbara Wappenschmidt, Tomas Zima, Zdenek Kleibl a Petra Kleiblova. The Breast [online], 2024, 75, 103721.
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Major improvement in thyroid cancer survival of elderly patients in the Nordic countries. Zitrický, František, Anni Koskinen, Vaclav Liska, Asta Försti, Akseli Hemminki a Kari Hemminki. European Journal of Endocrinology [online], 2024, 190(3), K32–K36.
Integrative NGS testing reveals clonal dynamics of adverse genomic defects contributing to a natural progression in treatment-naïve CLL patients. Veronika Navrkalová, Karla Plevová, Lenka Radová, Jakub Paweł Porc, Karol Pál, Jitka Malčíková, Šárka Pavlová, Michael Doubek, Anna Panovská, Jana Kotašková a Šárka Pospíšilová. British journal of haematology. Hoboken: Wiley-Blackwell, 2024, roč. 204, č. 1, s. 240-249.
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De novo accelerated phase of chronic myeloid leukemia should be recognized even in the era of tyrosine kinase inhibitors. Tomáš Horňák, Jiří Mayer, Petra Čičátková, Lukáš Semerád, Anežka Kvetková, Hana Klamova, Edgar Faber, Petra Belohlavkova, Michal Karas, Lukas Stejskal, Eduard Cmunt, Olga Cerna, Dana Srbova, Hana Zizkova, Lucia Vrablova, Ivana Skoumalova, Jaroslava Voglova, Tereza Jurkova, Marika Chrpava, Tomáš Jurček, Ivana Ježíšková, Marie Jarošová, Katerina Machova Polakova, Tomas Papajik, Pavel Zak, Pavel Jindra a Daniela Žáčková. American Journal of Hematology. Hoboken: Wiley-Blackwell, 2024, 4 s.
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Proteomic analysis of ascitic extracellular vesicles describes tumour microenvironment and predicts patient survival in ovarian cancer. Anna Vyhlídalová Kotrbová, Kristína Gömöryová, Antónia Mikulová, Hana Plešingerová, Stanislava Sladeček, Marek Kravec, Šárka Hrachovinová, David Potěšil, Garett Dunsmore, Camille Bleriot, Mathilde Bied, Jan Kotouček, Markéta Bednaříková, Jitka Hausnerová, Luboš Minář, Igor Crha, Michal Felsinger, Zbyněk Zdráhal, Florent Ginhoux, Vít Weinberger, Vítězslav Bryja a Vendula Hlaváčková Pospíchalová. Journal of Extracellular Vesicles. Wiley, 2024, roč. 13, č. 3, s. 1-22.
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Critical appraisal of the piRNA-PIWI axis in cancer and cancer stem cells. Elena Garcia-Borja, František Siegl, Rosana Mateu, Ondřej Slabý, Aleksi Šedo, Petr Bušek a Jiří Šána. Biomarker Research. London: BMC, 2024, roč. 12, č. 1, s. 1-24.
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STAT3 couples activated tyrosine kinase signaling to the oncogenic core transcriptional regulatory circuitry of anaplastic large cell lymphoma. Nicole Prutsch, Shuning He, Alla Berezovskaya, Adam D Durbin, Neekesh V Dharia, Kelsey A Maher, Jamie D Matthews, Lucy Hare, Suzanne Dawn Turner, Kimberly Stegmaier, Lukas Kenner, Olaf Merkel, A Thomas Look, Brian J Abraham a Mark W Zimmerman. Cell Reports Medicine. Amsterda: Elsevier, 2024, roč. 5, č. 3, s. 1-20.
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Adjuvant radiotherapy after brain metastasectomy: analysis of consecutive cohort of 118 patients from real world practice. Pavel Fardus, Václav Vybíhal, Ivana Rošková, Iveta Selingerová, Martin Smrčka, Radim Jančálek, Jiří Šána, Ondřej Slabý, Petr Pospíšil, Ludmila Hynková, Jan Garcic, Renata Belanová, Jan Kristek, Andrea Šprláková-Puková, Zdeněk Mackerle, Vilém Juráň, Marek Sova, Eduard Neuman, Hana Valeková, Radek Lakomý, Miloš Holánek, Roman Hrstka, Michaela Švajdová, Kateřina Poláchová, Ivana Koloušková, Pavel Šlampa a Tomáš Kazda. Reports of Practical Oncology and Radiotherapy. Gdansk: Via Medica, 2024, roč. 29, č. 1, s. 30-41.
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Optimized procedure for high-throughput transcriptome profiling of small extracellular vesicles isolated from low volume serum samples. Petra Vychytilová, Sára Vilmanová, Lucie Pifková, Tina Catela Ivković, Marie Madrzyk, Robin Jugas, Táňa Macháčková, Jan Kotouček, Milana Šachlová, Lucia Bohovicová, Teodor Staněk, Jana Halámková, Igor Kiss a Ondřej Slabý. Clinical Chemistry and Laboratory Medicine. Berlin: Walter De Gruyter, 2024, roč. 62, č. 1, s. 157-167.
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ChannelsDB 2.0: a comprehensive database of protein tunnels and pores in AlphaFold era. Anna Špačková, Ondřej Vávra, Tomáš Raček, Václav Bazgier, David Sehnal, Jiří Damborský, Radka Svobodová, David Bednář a Karel Berka. Nucleic Acids Research. Oxford University Press, 2024, roč. 52, D1, s. "D413"-"D418", 6 s.
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ChOP-CT: quantitative morphometrical analysis of the Hindbrain Choroid Plexus by X-ray micro-computed tomography. Viktória Parobková, Petra Kompaníková, Jakub Lázňovský, Michaela Kavková, Marek Hampl, Marcela Buchtová, Tomáš Zikmund, Jozef Kaiser a Vítězslav Bryja. Fluids and Barriers of the CNS. BMC, 2024, roč. 21, č. 1, s. 1-18.
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Orthotopic model for the analysis of melanoma circulating tumor cells. Markéta Pícková, Zuzana Kahounová, Tomasz Witold Radaszkiewicz, Jiřina Procházková, Radek Fedr, Michaela Nosková, Katarzyna Anna Radaszkiewicz, Petra Ovesná, Vítězslav Bryja a Karel Souček. Scientific Reports. Nature Research, 2024, roč. 14, č. 1, s. 1-13.
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Targeting NRAS via miR-1304-5p or farnesyltransferase inhibition confers sensitivity to ALK inhibitors in ALK-mutant neuroblastoma. Perla Pucci, Liam C Lee, Miaojun Han, Jamie D Matthews, Leila Jahangiri, Michaela Sschlederer, Eleanor Manners, Annabel Sorby-Adams, Joshua Kaggie, Ricky M Trigg, Christopher Steel, Lucy Hare, Emily R James, Nina Prokoph, Stephen P Ducray, Olaf Merkel, Firkret Rifatbegovic, Ji Luo, Sabine Taschner-Mandl, Lukas Kenner, G A Amos Burke a Suzanne Dawn Turner. Nature Communications. Berlin: Nature, 2024, roč. 15, č. 1, s. 1-19.
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Ligand bias underlies differential signaling of multiple FGFs via FGFR1. Kelly Karl, Del Piccolo Nuala, Taylor Light, Tanaya Roy, Pooja Dudeja, Vlad-Constantin Ursachi, Bohumil Fafílek, Pavel Krejčí a Kalina Hristova. eLife. Cambridge: eLife Sciences Publications Ltd, 2024, roč. 12, April 2024, s. 1-28.
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Unveiling the dynamics and molecular landscape of a rare chronic lymphocytic leukemia subpopulation driving refractoriness: insights from single-cell RNA sequencing. Terézia Kurucová, Kamila Réblová, Pavlína Janovská, Jakub Paweł Porc, Veronika Navrkalová, Šárka Pavlová, Jitka Malčíková, Karla Plevová, Boris Tichý, Michael Doubek, Vítězslav Bryja, Jana Kotašková a Šárka Pospíšilová. Molecular oncology. Hoboken: Wiley, 2024, 13 s.
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In-cell NMR suggests that DNA i-motif levels are strongly depleted in living human cells. Pavlína Víšková, Eva Ištvánková, Jan Ryneš, Šimon Džatko, Tomáš Loja, Martina Lenarčič Živkovic, Riccardo Rigo, Roberto El-Khoury, Israel Serrano-Chacon, Masad J Damha, Carlos Gonzalez, Jean-Louis Mergny, Silvie Trantírková a Lukáš Trantírek. Nature Communications. Berlin: Nature, 2024, roč. 15, č. 1, 12 s.
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MiR-4646-5p Acts as a Tumor-Suppressive Factor in Triple Negative Breast Cancer and Targets the Cholesterol Transport Protein GRAMD1B. Katharina Jonas, Felix Prinz, Manuela Ferracin, Katarina Krajina, Alexander Deutsch, Tobias Madl, Beate Rinner, Ondřej Slabý, Christiane Klec a Martin Pichler. Non-coding RNA. Švýcarsko: MDPI, 2024, roč. 10, č. 1, s. 1-24.
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ERIC recommendations for TP53 mutation analysis in chronic lymphocytic leukemia-2024 update. Jitka Malčíková, Šárka Pavlová, Panagiotis Baliakas, Thomas Chatzikonstantinou, Eugen Tausch, Mark Catherwood, Davide Rossi, Thierry Soussi, Boris Tichy, Arnon P Kater, Carsten U Niemann, Frederic Davi, Gianluca Gaidano, Stephan Stilgenbauer, Richard Rosenquist, Kostas Stamatopoulos, Paolo Ghia a Šárka Pospíšilová. Leukemia. London: Nature Publishing Group, 2024, 14 s.
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PredictONCO: a web tool supporting decision-making in precision oncology by extending the bioinformatics predictions with advanced computing and machine learning. Jan Štourač, Simeon Borko, Rayyan Tariq Khan, Petra Pokorná, Adam Dobiáš, Joan Planas Iglesias, Stanislav Mazurenko, José Gaspar Rangel Pamplona Pizarro Pinto, Veronika Szotkowská, Jaroslav Štěrba, Ondřej Slabý, Jiří Damborský a David Bednář. Briefings in Bioinformatics. Oxford University Press, 2024, roč. 25, č. 1, s. 1-10.
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A replicating LCMV-based vaccine for the treatment of solid tumors. Purde Mette-Triin, Jovana Cupovic, Yannick A Palmowski, Ahmad Makky, Sarah Schmidt, Alexander Rochwarger, Fabienne Hartmann, Felix Stemeseder, Alexander Lercher, Abdou Marie-Therese, David Bomze, Lenka Bešše, Fiamma Berner, Thomas Tüting, Michael Hölzel, Andreas Bergthaler, Stefan Kochanek, Burkhard Ludewig, Henning Lauterbach, Klaus K Orlinger, Tobias Bald, Andrea Schietinger, Christian Schürch, Sandra S Ring a Lukas Flatz. Molecular Therapy. Cambridge: Cell Press, 2024, roč. 32, č. 2, s. 426-439.
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A sodium/potassium switch for G4-prone G/C-rich sequences. Yu Luo, Martina Lenarčič Živkovic, Jiawei Wang, Jan Ryneš, Silvie Trantírková, Lukáš Trantírek, Daniela Verga a Jean-Louis Mergny. Nucleic acids research. Oxford: Oxford University Press, 2024, roč. 52, č. 1, s. 448-461.
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Global interactome mapping reveals pro-tumorigenic interactions of NF-κB in breast cancer. Petr Lapčík, R. Greg Stacey, David Potěšil, Petr Kulhánek, Leonard J. Foster a Pavel Bouchal. Molecular and Cellular Proteomics. Elsevier, 2024, roč. 23, č. 4, s. 1-20.
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Why are not all eligible chronic myeloid leukemia patients willing to attempt tyrosine kinase inhibitor discontinuation? A Czech nationwide analysis related to the TKI stopping trial HALF. Daniela Žáčková, Lukáš Semerád, Edgar Faber, Hana Klamová, Lukáš Stejskal, Petra Bělohlávková, Michal Karas, Eduard Cmunt, Olga Černá, Jiřina Procházková, Petra Čičátková, Anežka Kvetková, Tomáš Horňák, Ivana Skoumalová, Dana Srbová, Cyril Šálek, David Buffa, Jaroslava Voglová, Tomáš Jurček, Adam Folta, Ivana Ježíšková, Hana Žižková, Kateřina Machová Poláková, Tomáš Papajík, Pavel Žák, Pavel Jindra, Adam Svobodník, Radka Štěpánová a Jiří Mayer. Leukemia. London: Springer Nature, 2024, roč. 38, č. 4, s. 893-897.
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Unilateral hippocampal sparing during whole brain radiotherapy for multiple brain metastases: narrative and critical review. Petr Pospíšil, Ludmila Hynková, Lucie Hnidáková, Jana Maistryszinová, Pavel Šlampa a Tomáš Kazda. Frontiers in Oncology. Lausanne: Frontiers Media SA, 2024, roč. 14, January 2024, s. 1-11.
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Hippocampal subfield volumetric changes after radiotherapy for brain metastases. Klára Holíková, Iveta Selingerova, Petr Pospíšil, Martin Bulik, Ludmila Hynková, Ivana Kolouskova, Lucie Hnidakova, Petr Burkoň, Marek Slávik, Jiří Šána, Tomáš Holeček, Jiří Vaníček, Pavel Šlampa, Radim Jančálek a Tomáš Kazda. Neuro-Oncology Advances. Oxford: Oxford Univ Press, 2024, roč. 6, č. 1, 9 s.
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Investigation of long non-coding RNAs in extracellular vesicles from low-volume blood serum specimens of colorectal cancer patients. Marie Boudná, Táňa Macháčková, Petra Vychytilová, Karolína Trachtová, Renata Bartošová, Tina Catela Ivković, Dagmar Al Tukmachi, Robin Jugas, Lucie Pifková, Jana Orlíčková, Jan Kotouček, Marketa Pavlikova, Milana Šachlová, Lucia Bohovicová, Teodor Staněk, Jana Halámková, Igor Kiss, Tomáš Grolich, Martin Svoboda, Zdeněk Kala, Kamila Součková a Ondřej Slabý. Clinical and Experimental Medicine. Milan: Springer-Verlag Italia SRL, 2024, roč. 24, č. 1, s. 1-14.
doi: 10.1007/s10238-024-01323-1. PMID: 38568288
Real-world data on diagnostics, treatment and outcomes of patients with hairy cell leukemia: The HCL-CLLEAR study. Anna Panovská, Pavel Zak, Tereza Jurkova, Tomáš Arpáš, Yvona Brychtová, Alžběta Vašíčková, Viera Hrabáčková, Adéla Prchlíková, Martina Filipová a Michael Doubek. Hematological Oncology. Hoboken: Wiley-Blackwell, 2024, roč. 42, č. 3, s. 1-9.
doi: 10.1002/hon.3280. PMID: 38741354
IκBε deficiency accelerates disease development in chronic lymphocytic leukemia. Jessica Bordini, Chiara Lenzi, Michela Frenquelli, Alessia Morabito, Athanasios Pseftogas, Daniela Belloni, Larry Mansouri, George Tsiolas, Eleonora Perotta, Pamela Ranghetti, Francesca Gandini, Francesca Genova, Daniel Hagerstrand, Georgios Gavriilidis, Sofoklis Keisaris, Nikolaos Pechlivanis, Frederic Davi, Neil E Kay, Anton W Langerak, Šárka Pospíšilová, Lydia Scarfo, Antonios Makris, Fotis E Psomopoulos, Kostas Stamatopoulos, Richard Rosenquist, Alessandro Campanella a Paolo Ghia. Leukemia. London: Nature Publishing Group, 2024, 12 s.
doi: 10.1038/s41375-024-02236-4.
Precision immuno-oncology approach for four malignant tumors in siblings with constitutional mismatch repair deficiency syndrome. Hana Pálová, Anirban Das, Petra Pokorná, Viera Bajčiová, Zdenek Pavelka, Marta Ježová, Karol Pál, Jose R Dimayacyac, Logine Negm, Lucie Stengs, Vanessa Bianchi, Klára Vejmělková, Kristýna Nosková, Marie Jarošová, Soňa Mejstříková, Peter Múdry, Michal Kýr, Tomáš Merta, Pavel Tinka, Klára Drábová, Štefánia Aulická, Robin Jugas, Uri Tabori, Ondřej Slabý a Jaroslav Štěrba. NPJ Precision Oncology. Belin: Nature Portfolio, 2024, roč. 8, č. 1, s. 1-9.
doi: 10.1038/s41698-024-00597-8.
Strategies for labelling of exogenous and endogenous extracellular vesicles and their application for in vitro and in vivo functional studies. Marie Boudná, Andres Delgado Campos, Petra Vychytilová, Táňa Macháčková, Ondřej Slabý a Kamila Součková. Cell Communication and Signaling. London: BMC, 2024, roč. 22, č. 1, s. 1-15.
doi: 10.1186/s12964-024-01548-3. PMID: 38461237
Toxicity of external beam accelerated partial-breast irradiation (APBI) in adjuvant therapy of early-stage breast cancer: prospective randomized study. Petr Burkoň, Iveta Selingerová, Marek Slávik, Miloš Holánek, Miroslav Vrzal, Oldřich Coufal, Kateřina Poláchová, Petr Müller, Pavel Šlampa a Tomáš Kazda. Radiation Oncology. BMC: Elsevier, 2024, roč. 19, č. 1, s. 1-12.
doi: 10.1186/s13014-024-02412-x. PMID: 38310249
FasL impacts Tgfb signaling in osteoblastic cells. Adela Kratochvilova, Lucia Knopfová, Janka Gregorkova, Reinhard Gruber, Eva Janeckova, Yang Chai a Eva Matalova. Cells & Development. Elsevier B.V., 2024, 6 s.
doi: 10.1016/j.cdev.2024.203929. PMID: 38810946
InVADo: Interactive Visual Analysis of Molecular Docking Data. Marco Schäfer, Nicolas Brich, Jan Byška, Sérgio Manuel Marques, David Bednář, Philipp Thiel, Barbora Kozlíková a Michael Krone. IEEE Transactions on Visualization and Computer Graphics. IEEE Computer Society, 2024, roč. 30, č. 4, s. 1984-1997.
doi: 10.1109/TVCG.2023.3337642. PMID: 38019636
Caspase-9 Is a Positive Regulator of Osteoblastic Cell Migration Identified by diaPASEF Proteomics. Kamila Říhová, Petr Lapčík, Barbora Veselá, Lucia Knopfová, David Potěšil, Jana Pokludová, Jan Šmarda, Eva Matalová, Pavel Bouchal a Petr Beneš. Journal of Proteome Research. American Chemical Society, 2024, 13 s.
doi: 10.1021/acs.jproteome.3c00641. PMID: 38498986
Emerging roles of prominin-1 (CD133) in the dynamics of plasma membrane architecture and cell signaling pathways in health and disease. Petr Pleskač, Christine A. Fargeas, Renata Veselská, Denis Corbeil a Jan Škoda. Cellular and Molecular Biology Letters. BMC, 2024, roč. 29, č. 1, s. 1-47.
doi: 10.1186/s11658-024-00554-0. PMID: 38532366
Challenges with hippocampal MR spectroscopy as a surrogate for pre-radiotherapy assessment of neurocognitive impairment in patients with brain metastasis. Iveta Selingerová, Klára Holíková, Tomas Chodur, Ludmila Hynková, Petr Pospíšil, Martin Bulik, Renata Belanová, Kamila Siffelova, Ivana Koloušková, Marek Slávik, Petr Burkoň, Roman Hrstka, Radim Jančálek, Jiří Šána, Pavel Šlampa a Tomáš Kazda. Biomedical Papers, Olomouc: Palacky University. Olomouc: Palacky University, 2024, 8 s.
doi: 10.5507/bp.2024.012. PMID: 38623639
Blockage of BCL-XL overcomes venetoclax resistance across BCL2-positive lymphoid malignancies irrespective of BIM status. Alexandra Dolnikova, Dmitry Kazanstev, Magdalena Klanova, Eva Pokorna, Dana Sovilj, Cristina Daniela Kelemen, Liliana Tuskova, Eva Hoferková, Marek Mráz, Karel Helman, Nikola Curik, Katerina Machova Polakova, Ladislav Anděra, Marek Trněný a Pavel Klener. Blood Advances. Amsterdam: Elsevier, 2024, roč. 10.1182/bl.
doi: 10.1182/bloodadvances.2024012906. PMID: 38713893
Stromal cells engineered to express T cell factors induce robust CLL cell proliferation in vitro and in PDX co-transplantations allowing the identification of RAF inhibitors as anti-proliferative drug. Eva Hoferková, Václav Šeda, Soňa Cesnáriková, Jan Verner, Tomáš Loja, Květoslava Matulová, Hana Skuhrová Francová, Eva Ondroušková, Daniel Filip, Nicolas Blavet, Miroslav Boudný, Gabriela Mladonická Pavlasová, Josef Večeřa, Laura Ondrišová, Petra Pavelková, Kryštof Hlaváč, Lenka Košťálová, Androniki Michaelou, Šárka Pospíšilová, Jana Dorazilová, Václav Chochola, Josef Jaroš, Michael Doubek, Marie Jarošová, Aleš Hampl, Lucy Vojtová, Leoš Křen, Jiří Mayer a Marek Mráz. Leukemia. London: Springer Nature, 2024.
doi: 10.1038/s41375-024-02284-w. PMID: 38877102
Unraveling the epigenetic landscape of pulmonary arterial hypertension: implications for personalized medicine development. Jaydev Dave, Vineeta Jagana, Radoslav Janostiak, Malik Bisserier. J Transl Med. 2023 Jul 17;21(1):477.
doi: 10.1186/s12967-023-04339-5. PMID: 37461108; PMCID: PMC10353122.
2023
Sequencing-based analysis of clonal evolution of 25 mantle cell lymphoma patients at diagnosis and after failure of standard immunochemotherapy. Jana Karolová, Dmitry Kazantsev, Michael Svatoň, Liliana Tušková, Kristina Forsterová, Diana Maláriková, Kateřina Benešová, Tomáš Heizer, Alexandra Dolníková, Magdalena Klánová, Lucie Winkowska, Karla Svobodová, Jan Hojný, Eva Krkavcová, Eva Froňková, Zuzana Zemanová, Marek Trněný, Pavel Klener. Am J Hematol. 2023; 98(10): 1627-1636.
doi:10.1002/ajh.27044. PMID: 37605345
Early-Onset Ovarian Cancer <30 Years: What Do We Know about Its Genetic Predisposition? Klara Horackova, Marketa Janatova, Petra Kleiblova, Zdenek Kleibl and Jana Soukupova. Int J Mol Sci. 2023 Nov 30;24(23):17020.
doi: 10.3390/ijms242317020. PMID: 38069345; PMCID: PMC10707471.
Total neoadjuvant therapy in rectal cancer: the evidence and expectations. Ludmila Boublikova, Alena Novakova, Jaromir Simsa, Radka Lohynska. Critical Reviews in Oncology/hematology. 2023 Dec;192:104196.
doi: 10.1016/j.critrevonc.2023.104196. PMID: 37926376.
Combination of quinoxaline with pentamethinium system: Mitochondrial staining and targeting. Zdeněk Kejík, Nela Koubková, Lucie Krčová, David Sýkora, Nikita Abramenko, Kateřina Veselá, Robert Kaplánek, Jan Hajduch, Magdalena Houdová Megová, Petr Bušek, Aleksi Šedo, Lukáš Lacina, Karel Smetana Jr., Pavel Martásek, Milan Jakubek. Bioorg Chem. 2023 Dec;141:106816.
doi: 10.1016/j.bioorg.2023.106816. PMID: 37716274.
TET protein inhibitors: Potential and limitations. Robert Kaplánek, Zdeněk Kejík, Jan Hajduch, Kateřina Veselá, Kateřina Kučnirová, Markéta Skaličková, Anna Venhauerová, Božena Hosnedlová, Róbert Hromádka, Petr Dytrych, Petr Novotný, Nikita Abramenko, Veronika Antonyová, David Hoskovec, Petr Babula, Michal Masařík, Pavel Martásek, Milan Jakubek.. Biomed Pharmacother. 2023 Oct;166:115324.
doi: 10.1016/j.biopha.2023.115324. PMID: 37598475.
Fibroblast activation protein as a potential theranostic target in brain metastases of diverse solid tumours. Michal Zubaľ, Barbora Výmolová, Ivana Matrasová, Petr Výmola, Jana Vepřková, Martin Syrůček, Robert Tomáš, Zdislava Vaníčková, Evžen Křepela, Dora Konečná, Petr Bušek, Aleksi Šedo. Pathology. 2023 Oct;55(6):806-817.
doi: 10.1016/j.pathol.2023.05.003. PMID: 37419841.
Tuning polymer-blood and polymer-cytoplasm membrane interactions by manipulating the architecture of poly(2-oxazoline) triblock copolymers. Volodymyr Lobaz, Veronika Liščáková, František Sedlák, Dominik Musil, Svetlana Lukáš Petrova, Ivana Šeděnková, Jiří Pánek, Jan Kučka, Rafał Konefał, Eva Tihlaříková, Vilém Neděla, Jan Pankrác, Luděk Šefc, Martin Hrubý, Pavel Šácha, Petr Štěpánek. Colloids Surf B Biointerfaces. 2023 Nov; 231:113564.
doi: 10.1016/j.colsurfb.2023.113564. PMID: 37742364.
Dual detection system for cancer-associated point mutations assisted by a multiplexed LNA-based amperometric bioplatform coupled with rolling circle amplification, Ravery Sebuyoya, Alejandro Valverde, Ludmila Moranova, Johana Strmiskova, Roman Hrstka, Víctor Ruiz-Valdepeñas Montiel, José M. Pingarrón, Rodrigo Barderas, Susana Campuzano, Martin Bartosik. Sensors and Actuators B: Chemical, Volume 394, 2023, 134375.
doi: 10.1016/j.snb.2023.134375.
Primary assessment of medicines for expected migrastatic potential with holographic incoherent quantitative phase imaging. Markéta Šuráňová, Miroslav Ďuriš, Irena Štenglová Netíková, Jan Brábek, Tomáš Horák, Veronika Jůzová, Radim Chmelík, Pavel Veselý. Biomed Opt Express. 2023 May 16;14(6):2689-2708.
doi: 10.1364/BOE.488630. PMID: 37342686; PMCID: PMC10278600.
Phosphorylation of tyrosine 90 in SH3 domain is a new regulatory switch controlling Src kinase. Lenka Koudelková, Markéta Pelantová, Zuzana Brůhová, Martin Sztacho, Vojtěch Pavlík, Dalibor Pánek, Jakub Gemperle, Pavel Talacko, Jan Brábek, Daniel Rösel. Elife. 2023 Jul 10;12:e82428.
doi: 10.7554/eLife.82428. PMID: 37428018; PMCID: PMC10361714.
Th1/interferon-γ bias in 22q11.2 deletion syndrome is driven by memory T cells and exacerbated by IL-7. Ondrej Vladyka, Petra Vrabcova, Michaela Reiterova, Zuzana Parackova, Robert Haesler, Anna Sediva, Tomas Kalina, Adam Klocperk. Clin Immunol. 2023 Nov; 256:109793.
doi: 10.1016/j.clim.2023.109793. PMID: 37776967.
Posttreatment positivity of BCR::ABL1 in acute lymphoblastic leukemia: Should we keep track? Jan Zuna, Lenka Hovorkova, Justina Krotka, Lucie Winkowska, Zbynek Novak, Lucie Sramkova, Jan Stary, Jan Trka, Giovanni Cazzaniga, Gunnar Cario, Marketa Zaliova. Am J Hematol. 2023 Oct;98(10):E269-E271.
doi: 10.1002/ajh.27022. PMID: 37449465.
Chimeric JAK2 Kinases Trigger Non-uniform Changes of Cellular Metabolism in BCR-ABL1-like Childhood ALL. Julius Lukes Jr, Eliska Potuckova, Natividad Alquezar-Artieda, Ivana Hermanova, Sladjana Kosanovic, Katerina Hlozkova, Meritxell Alberich Jorda, Jan Zuna, Jan Trka, Daniel A Tennant, Martin Stanulla, Marketa Zaliova, Julia Starkova. Hemasphere. 2023 Aug 23;7(9):e946.
doi: 10.1097/HS9.0000000000000946. PMID: 37637992; PMCID: PMC10448929.
Hybrid Macromolecular Constructs as a Platform for Spectral Nanoprobes for Advanced Cellular Barcoding in Flow Cytometry. Júlia Kudláčová, Daniela Kužílková, František Bárta, Naděžda Brdičková, Adéla Vávrová, Libor Kostka, Ondřej Hovorka, Tomáš Kalina, Tomáš Etrych. Macromol Biosci. 2023 Sep 11:e2300306.
doi: 10.1002/mabi.202300306. PMID: 37691533.
Survival in melanoma in the nordic countries into the era of targeted and immunological therapies. Filip Tichanek, Asta Försti, Akseli Hemminki, Otto Hemminki, Kari Hemminki. Eur J Cancer. 2023 Jun;186:133-141.
doi: 10.1016/j.ejca.2023.03.019. PMID: 37068406; PMCID: PMC10209636.
Survival in Lung Cancer in the Nordic Countries Through A Half Century. Filip Tichanek, Asta Försti, Otto Hemminki, Akseli Hemminki, Kari Hemminki. Clin Epidemiol. 2023 May 1;15:503-510.
doi: 10.2147/CLEP.S406606. PMID: 37153073; PMCID: PMC10162394.
The dynamics of telomere length in primary and metastatic colorectal cancer lesions. Michal Kroupa, Ondrej Kubecek, Kristyna Tomasova, Petr Hanak, Marketa Krupova, Klara Cervena, Anna Siskova, Jachym Rosendorf, Petr Hosek , Ludmila Vodickova, Pavel Vodicka, Vaclav Liska, Stanislav John, Veronika Vymetalkova, Jiri Petera. Sci Rep. 2023 Jun 5;13(1):9097.
doi: 10.1038/s41598-023-35835-9. PMID: 37277368; PMCID: PMC10241861.
A Fecal MicroRNA Signature by Small RNA Sequencing Accurately Distinguishes Colorectal Cancers: Results From a Multicenter Study. Barbara Pardini, Giulio Ferrero, Sonia Tarallo, Gaetano Gallo, Antonio Francavilla, Nicola Licheri, Mario Trompetto, Giuseppe Clerico, Carlo Senore, Sergio Peyre, Veronika Vymetalkova, Ludmila Vodickova, Vaclav Liska, Ondrej Vycital, Miroslav Levy, Peter Macinga, Tomas Hucl, Eva Budinska, Pavel Vodicka, Francesca Cordero, Alessio Naccarati. Gastroenterology. 2023 Sep;165(3):582-599.e8.
doi: 10.1053/j.gastro.2023.05.037. PMID: 37263306.
Autoimmune diseases as comorbidities for liver, gallbladder, and biliary duct cancers in Sweden. Kari Hemminki, Kristina Sundquist, Jan Sundquist, Asta Försti, Vaclav Liska, Akseli Hemminki, Xinjun Li. Cancer. 2023 Jan 30.
doi: 10.1002/cncr.34663. PMID: 36715017.
Type I interferon signaling in malignant blasts contributes to treatment efficacy in AML patients. Peter Holicek, Iva Truxova, Jana Rakova, Cyril Salek, Michal Hensler, Marek Kovar, Milan Reinis, Romana Mikyskova, Josef Pasulka, Sarka Vosahlikova, Hana Remesova, Iva Valentova, Daniel Lysak, Monika Holubova, Petr Kaspar, Jan Prochazka, Lenka Kasikova, Radek Spisek, Lorenzo Galluzzi, Jitka Fucikova. Cell Death Dis. 2023 Mar 24;14(3):209.
doi: 10.1038/s41419-023-05728-w. PMID: 36964168; PMCID: PMC10039058.
Regulatory T cells suppress the formation of potent KLRK1 and IL-7R expressing effector CD8 T cells by limiting IL-2. Oksana Tsyklauri, Tereza Chadimova, Veronika Niederlova, Jirina Kovarova, Juraj Michalik, Iva Malatova, Sarka Janusova, Olha Ivashchenko, Helene Rossez, Ales Drobek, Hana Vecerova, Virginie Galati, Marek Kovar, Ondrej Stepanek. Elife. 2023 Jan 27;12:e79342.
doi: 10.7554/eLife.79342. PMID: 36705564; PMCID: PMC9977273.
IL-2-driven CD8+ T cell phenotypes: implications for immunotherapy. Veronika Niederlova, Oksana Tsyklauri, Marek Kovar, Ondrej Stepanek. Trends Immunol. 2023 Nov;44(11):890-901.
doi: 10.1016/j.it.2023.09.003. PMID: 37827864; PMCID: PMC7615502.
Antifouling Properties of Poly(2-Oxazoline)s and Poly(2-Oxazine)s: Direct Comparison of Polymer-Coated Surfaces with the Same Coating Parameters. Jan Svoboda, Niccolo Lusiani, Radoslava Sivkova, Ognen Pop-Georgievski, Ondrej Sedlacek. Macromol Rapid Commun. 2023 Sep;44(17):e2300168.
doi: 10.1002/marc.202300168. PMID: 37220400.
Hydrophilic Copolymers with Hydroxamic Acid Groups as a Protective Biocompatible Coating of Maghemite Nanoparticles: Synthesis, Physico-Chemical Characterization and MRI Biodistribution Study. Hana Charvátová, Zdeněk Plichta, Jiřina Hromádková, Vít Herynek, Michal Babič. Pharmaceutics. 2023 Jul 19;15(7):1982.
doi: 10.3390/pharmaceutics15071982. PMID: 37514168; PMCID: PMC10384990.
Polyelectrolyte nanoparticles based on poly[N-(2-hydroxypropyl)methacrylamide-block-poly(N-(3-aminopropyl)methacrylamide] copolymers for delivery of heparin-binding proteins. Gabriela S. García-Briones, Richard Laga, Zulfiya Černochová, Carely Arjona-Ruiz, Olga Janoušková, Miroslav Šlouf, Ognen Pop-Georgievski, Dana Kubies. European Polymer Journal, Volume 191, 2023, 111976, ISSN 0014-3057.
doi: 10.1016/j.eurpolymj.2023.111976.
Singlet Oxygen In Vivo: It Is All about Intensity-Part 2. Steffen Hackbarth, Shanghui Gao, Vladimír Šubr, Lisheng Lin, Jakob Pohl, Tomáš Etrych, Jun Fang. J Pers Med. 2023 Apr 30;13(5):781.
doi: 10.3390/jpm13050781. PMID: 37240951; PMCID: PMC10222680.
Adaptable polymerization platform for therapeutics with tunable biodegradability. Hrochová M, Kotrchová L, Frejková M, Konefał R, Gao S, Fang J, Kostka L, Etrych T. Acta Biomater. 2023 Nov;171:417-427.
doi: 10.1016/j.actbio.2023.09.004. PMID: 37696413.
Stimuli-Responsive Polymer Nanoprobes Intended for Fluorescence-Guided Surgery of Malignant Head-and-Neck Tumors and Metastases. Robert Pola, Eliška Grosmanová, Michal Pechar, Dominik Horák, Tereza Krunclová, Jan Pankrác, Maxime Henry, Martin Kaňa, Jan Bouček, Luděk Šefc, Jean-Luc Coll, Tomáš Etrych. Adv Healthc Mater. 2023 Nov;12(28):e2301183.
doi: 10.1002/adhm.202301183. PMID: 37288946.
Polymer theranostics with multiple stimuli-based activation of photodynamic therapy and tumor imaging. Marina Rodrigues Tavares, Rayhanul Islam, Vladimír Šubr, Steffen Hackbarth, Shanghui Gao, Kai Yang, Volodymyr Lobaz, Jun Fang, Tomáš Etrych. Theranostics. 2023 Sep 4;13(14):4952-4973.
doi: 10.7150/thno.86211. PMID: 37771769; PMCID: PMC10526675.
The PANcreatic Disease ReseArch (PANDoRA) consortium: Ten years' experience of association studies to understand the genetic architecture of pancreatic cancer. Daniele Campa, Manuel Gentiluomo, Angelika Stein, Mateus Nóbrega Aoki, Martin Oliverius, Ludmila Vodičková, Krzysztof Jamroziak, George Theodoropoulos, Claudio Pasquali, William Greenhalf, Paolo Giorgio Arcidiacono, Faik Uzunoglu, Raffaele Pezzilli, Claudio Luchini, Marta Puzzono, Martin Loos, Matteo Giaccherini, Verena Katzke, Andrea Mambrini, Edita Kiudeliene, Kauffmann Emanuele Federico, Julia Johansen, Tamás Hussein, Beatrice Mohelnikova-Duchonova, Casper H J van Eijck, Hermann Brenner, Riccardo Farinella, Juan Sainz Pérez, Martin Lovecek, Markus W Büchler, Viktor Hlavac, Jakob R Izbicki, Thilo Hackert, Roger Chammas, Alessandro Zerbi, Rita Lawlor, Alessio Felici, Mara Götz, Gabriele Capurso, Laura Ginocchi, Maria Gazouli, Juozas Kupcinskas, Giulia Martina Cavestro, Pavel Vodicka, Stefania Moz, John P Neoptolemos, Lumir Kunovsky, Stig E Bojesen, Silvia Carrara, Domenica Gioffreda, Egidijus Morkunas, Olga Abian, Stefania Bunduc, Daniela Basso, Ugo Boggi, Barbara Wlodarczyk, Andrea Szentesi, Giuseppe Vanella, Inna Chen, Maarten F Bijlsma, Vytautas Kiudelis, Stefano Landi, Ben Schöttker, Chiara Corradi, Nathalia Giese, Rudolf Kaaks, Giulia Peduzzi, Péter Hegyi, Luca Morelli, Niccolò Furbetta, Pavel Soucek, Anna Latiano, Renata Talar-Wojnarowska, Sidsel C Lindgaard, Frederike Dijk, Anna Caterina Milanetto, Francesca Tavano, Klara Cervena, Bálint Erőss, Sabrina G Testoni, Judith H E Verhagen-Oldenampsen, Ewa Małecka-Wojciesko, Eithne Costello, Roberto Salvia, Evaristo Maiello, Stefano Ermini, Cosimo Sperti, Bernd Holleczek, Francesco Perri, Jurgita Skieceviciene, Livia Archibugi, Maurizio Lucchesi, Cosmeri Rizzato, Federico Canzian. Crit Rev Oncol Hematol. 2023 Jun;186:104020.
doi: 10.1016/j.critrevonc.2023.104020. PMID: 37164172.
Mitochondrially targeted tamoxifen in patients with metastatic solid tumours: an open-label, phase I/Ib single-centre trial. Zuzana Bielcikova, Jan Stursa, Ludmila Krizova, Lanfeng Dong, Jan Spacek, Stanislav Hlousek, Michal Vocka, Katerina Rohlenova, Olga Bartosova, Vladimir Cerny, Tomas Padrta, Michal Pesta, Pavel Michalek, Sona Stemberkova Hubackova, Katarina Kolostova, Eliska Pospisilova, Vladimir Bobek, Peter Klezl, Renata Zobalova, Berwini Endaya, Jakub Rohlena, Lubos Petruzelka, Lukas Werner, Jiri Neuzil. EClinicalMedicine. 2023 Feb 23;57:101873.
doi: 10.1016/j.eclinm.2023.101873. PMID: 37064512; PMCID: PMC10102891.
Targeting Prostate Cancer Using Bispecific T-Cell Engagers against Prostate-Specific Membrane Antigen. Gargi Das, Jakub Ptacek, Barbora Havlinova, Jana Nedvedova, Cyril Barinka, Zora Novakova. ACS Pharmacol Transl Sci. 2023 Oct 6;6(11):1703-1714.
doi: 10.1021/acsptsci.3c00159. PMID: 37974624.
Frentizole derivatives with mTOR inhibiting and senomorphic properties. Zofia Chrienova, David Rysanek, Josef Novak, Pavla Vasicova, Patrik Oleksak, Rudolf Andrys, Adam Skarka, Jelena Dumanovic, Zoran Milovanovic, Vesna Jacevic, Marketa Chvojkova, Kristina Holubova, Karel Vales, Veronika Skoupilova, Marian Valko, Klaudia Jomova, Suliman Y Alomar, Fernanda D Botelho, Tanos C C Franca, Kamil Kuca, Zdenek Hodny, Eugenie Nepovimova. Biomed Pharmacother. 2023 Nov;167:115600.
doi: 10.1016/j.biopha.2023.115600. PMID: 37783152.
Terminal differentiation of villus tip enterocytes is governed by distinct Tgfβ superfamily members. Linda Berková, Hassan Fazilaty, Qiutan Yang, Jan Kubovčiak, Monika Stastna, Dusan Hrckulak, Martina Vojtechova, Tosca Dalessi, Michael David Brügger, George Hausmann, Prisca Liberali, Vladimir Korinek, Konrad Basler, Tomas Valenta. EMBO Rep. 2023 Sep 6;24(9):e56454.
doi: 10.15252/embr.202256454. PMID: 37493498; PMCID: PMC10481656.
Ppm1d truncating mutations promote the development of genotoxic stress-induced AML. Monika Burocziova, Petr Danek, Anna Oravetzova, Zuzana Chalupova, Meritxell Alberich-Jorda, Libor Macurek. Leukemia. 2023 Nov;37(11):2209-2220.
doi: 10.1038/s41375-023-02030-8. PMID: 37709843; PMCID: PMC10624630.
ENIGMA CHEK2gether Project: A Comprehensive Study Identifies Functionally Impaired CHEK2 Germline Missense Variants Associated with Increased Breast Cancer Risk. Lenka Stolarova, Petra Kleiblova, Petra Zemankova, Barbora Stastna, Marketa Janatova, Jana Soukupova, Maria Isabel Achatz, Christine Ambrosone, Paraskevi Apostolou, Banu K Arun, Paul Auer, Mollie Barnard, Birgitte Bertelsen; Biobank Japan; Marinus J Blok, Nicholas Boddicker, Joan Brunet, Elizabeth S Burnside, Mariarosaria Calvello, Ian Campbell, Sock Hoai Chan, Fei Chen, Jian Bang Chiang, Anna Coppa, Laura Cortesi, Ana Crujeiras-González; Consortium CZECANCA; Kim De Leeneer, Robin De Putter, Allison DePersia, Lisa Devereux, Susan Domchek, Anna Efremidis, Christoph Engel, Corinna Ernst, D Gareth R Evans, Lidia Feliubadaló, Florentia Fostira, Olivia Fuentes-Ríos, Encarna B Gómez-García, Sara González, Christopher Haiman, Thomas van Overeem Hansen, Jan Hauke, James Hodge, Chunling Hu, Hongyan Huang, Nur Diana Binte Ishak, Yusuke Iwasaki, Irene Konstantopoulou, Peter Kraft, James Lacey, Conxi Lázaro, Na Li, Weng Khong Lim, Sara Lindstrom, Adriana Lori, Elana Martinez, Alexandra Martins, Koichi Matsuda, Giuseppe Matullo, Simone McInerny, Kyriaki Michailidou, Marco Montagna, Alvaro N A Monteiro, Luigi Mori, Katherine Nathanson, Susan L Neuhausen, Heli Nevanlinna, Janet E Olson, Julie Palmer, Barbara Pasini, Alpa Patel, Maria Piane, Bruce Poppe, Paolo Radice, Alessandra Renieri, Nicoletta Resta, Marcy E Richardson, Toon Rosseel, Kathryn J Ruddy, Marta Santamariña, Elizabeth Santana Dos Santos, Lauren Teras, Amanda E Toland, Amy Trentham-Dietz, Celine M Vachon, Alexander E Volk, Nana Weber-Lassalle, Jeffrey N Weitzel, Lisa Wiesmuller, Stacey Winham, Siddhartha Yadav, Drakoulis Yannoukakos, Song Yao, Valentina Zampiga, Magnus Zethoven, Ze Wen Zhang, Tomas Zima, Amanda B Spurdle, Ana Vega, Maria Rossing, Jesús Del Valle, Arcangela De Nicolo, Eric Hahnen, Kathleen B M Claes, Joanne Ngeow, Yukihide Momozawa, Paul A James, Fergus J Couch, Libor Macurek, Zdenek Kleibl. Clin Cancer Res. 2023 Aug 15;29(16):3037-3050.
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Chronic inflammation promotes cancer progression as a second hit. Monika Burocziova, Srdjan Grusanovic, Karolina Vanickova, Sladjana Kosanovic, Meritxell Alberich-Jorda. Exp Hematol. 2023 Dec;128:30-37.
doi: 10.1016/j.exphem.2023.09.002. PMID: 37709251.
Hematopoietic stem cells undergo a lymphoid to myeloid switch in early stages of emergency granulopoiesis. Karolina Vanickova, Mirko Milosevic, Irina Ribeiro Bas, Monika Burocziova, Asumi Yokota, Petr Danek, Srdjan Grusanovic, Mateusz Chiliński, Dariusz Plewczynski, Jakub Rohlena, Hideyo Hirai, Katerina Rohlenova, Meritxell Alberich-Jorda. EMBO J. 2023 Dec 1;42(23):e113527.
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Discovery of tert-Butyl Ester Based 6-Diazo-5-oxo-l-norleucine Prodrugs for Enhanced Metabolic Stability and Tumor Delivery. Kateřina Novotná, Lukáš Tenora, Eva Prchalová, James Paule, Jesse Alt, Vijay Veeravalli, Jenny Lam, Ying Wu, Ivan Šnajdr, Sadakatali Gori, Vijaya Saradhi Mettu, Takashi Tsukamoto, Pavel Majer, Barbara S Slusher, Rana Rais. J Med Chem. 2023 Nov 23;66(22):15493-15510.
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Randomizing for Alzheimer's disease drug trials should consider the cancer history of participants. Viswanath Das, Marián Hajdúch. Brain. 2023 Oct 3;146(10):e75-e76.
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Drug-Drug Interactions of Cannabidiol with Standard-of-Care Chemotherapeutics. Tereza Buchtova, David Lukac, Zdenek Skrott, Katarina Chroma, Jiri Bartek, Martin Mistrik. Int J Mol Sci. 2023 Feb 2;24(3):2885.
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Increased blood reactive oxygen species and hepcidin in obstructive sleep apnea precludes expected erythrocytosis. Jihyun Song, Krishna M Sundar, Monika Horvathova, Radhika Gangaraju, Karel Indrak, Robert D Christensen, Samuel Genzor, Carsten Lundby, Vladimir Divoky, Tomas Ganz, Josef T Prchal. Am J Hematol. 2023 Aug;98(8):1265-1276.
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2,4-Diaryl-pyrimido[1,2-a]benzimidazole derivatives as novel anticancer agents endowed with potent anti-leukemia activity: Synthesis, biological evaluation and kinase profiling. Moataz A Shaldam, Denisa Hendrychová, Radwan El-Haggar, Veronika Vojáčková, Taghreed A Majrashi, Eslam B Elkaeed, Nicolas Masurier, Vladimír Kryštof, Haytham O Tawfik, Wagdy M Eldehna. Eur J Med Chem. 2023 Oct 5;258:115610.
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A unique case of AH-dominant type nodular pulmonary amyloidosis presenting as a spontaneous pneumothorax: a case report and review of the literature. Valeria Skopelidou, Pavel Hurník, Lubomír Tulinský, Vladimir Židlík, Jiří Lenz, Patricie Delongová, Helena Hornychová, Patrik Flodr, Tomáš Jelínek, Ludmila Muroňová, Dušan Holub, Petr Džubák, Marián Hajdúch. Pathol Oncol Res. 2023 Sep 22;29:1611390.
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Circulating tumor cell-derived preclinical models: current status and future perspectives. Zuzana Kahounová, Markéta Pícková, Stanislav Drápela, Jan Bouchal, Eva Szczyrbová, Jiří Navrátil, Karel Souček. Cell Death Dis. 2023 Aug 17;14(8):530.
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Discrimination of resected glioma tissues using surface enhanced Raman spectroscopy and Au@ZrO2 plasmonic nanosensor. Vaclav Ranc, Ondrej Pavlacka, Ondrej Kalita, Miroslav Vaverka. Spectrochim Acta A Mol Biomol Spectrosc. 2024 Jan 15;305:123521.
doi: 10.1016/j.saa.2023.123521. PMID: 37862838.
Nucleoside-based anticancer drugs: Mechanism of action and drug resistance. Lenka Hruba, Viswanath Das, Marian Hajduch, Petr Dzubak. Biochem Pharmacol. 2023 Sep;215:115741.
doi: 10.1016/j.bcp.2023.115741. PMID: 37567317.
Pathogenesis of Alzheimer's disease: Involvement of the choroid plexus. Maria Čarna, Isaac G Onyango, Stanislav Katina, Dušan Holub, Jan Sebastian Novotny, Marketa Nezvedova, Durga Jha, Zuzana Nedelska, Valentina Lacovich, Thijs Vande Vyvere, Ruben Houbrechts, Krystine Garcia-Mansfield, Ritin Sharma, Victoria David-Dirgo, Martin Vyhnalek, Kateřina Texlova, Hernan Chaves, Nadine Bakkar, Lucia Pertierra, Mojmir Vinkler, Hana Markova, Jan Laczo, Kateřina Sheardova, Marcela Hortova-Kohoutkova, Jan Frič, Giancarlo Forte, Petr Kaňovsky, Silvie Belaškova, Jiři Damborsky, Jakub Hort, Nicholas T Seyfried, Robert Bowser, Gustavo Sevlever, Robert A Rissman, Richard A Smith, Marian Hajduch, Patrick Pirrotte, Zdenek Spacil, Eric B Dammer, Clara Limbäck-Stokin, Gorazd B Stokin. Alzheimers Dement. 2023 Aug;19(8):3537-3554.
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More Than 2% of Circulating Tumor Plasma Cells Defines Plasma Cell Leukemia-Like Multiple Myeloma. Tomas Jelinek, Renata Bezdekova, David Zihala, Tereza Sevcikova, Anjana Anilkumar Sithara, Lenka Pospisilova, Sabina Sevcikova, Petra Polackova, Martin Stork, Zdenka Knechtova, Ondrej Venglar, Veronika Kapustova, Tereza Popkova, Ludmila Muronova, Zuzana Chyra, Matous Hrdinka, Michal Simicek, Juan-Jose Garcés, Noemi Puig, Maria-Teresa Cedena, Artur Jurczyszyn, Jorge J Castillo, Miroslav Penka, Jakub Radocha, Maria Victoria Mateos, Jesús F San-Miguel, Bruno Paiva, Ludek Pour, Lucie Rihova, Roman Hajek. J Clin Oncol. 2023 Mar 1;41(7):1383-1392.
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From fish to cells: Establishment of continuous cell lines from embryos of annual killifish Nothobranchius furzeri and N. kadleci. Kamila Součková, Matej Jasík, Iva Sovadinová, Alexandr Sember, Eliška Sychrová, Anna Konieczna, Vojtěch Bystrý, Iva Dyková, Radim Blažek, Karolína Lukšíková, Tomáš Pavlica, Marek Jankásek, Marie Altmanová, Jakub Žák, Adriana Zbončáková, Martin Reichard, Ondřej Slabý. Aquat Toxicol. 2023 Jun;259:106517.
doi: 10.1016/j.aquatox.2023.106517. PMID: 37087860.
Gemtuzumab ozogamicin plus midostaurin in conjunction with standard intensive therapy for FLT3- mutated acute myeloid leukemia patients - Czech center experience. Barbora Weinbergerová, Martin Čerňan, Tomáš Kabut, Lukáš Semerád, Natália Podstavková, Tomáš Szotkowski, Ivana Ježíšková, Jiří Mayer. Haematologica. 2023 Oct 1;108(10):2826-2829.
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Targeted treatment of severe vascular malformations harboring PIK3CA and TEK mutations with alpelisib is highly effective with limited toxicity. Martin Sterba, Petra Pokorna, Renata Faberova, Blanka Pinkova, Jarmila Skotakova, Anna Seehofnerova, Jan Blatny, Lucia Janigova, Olga Koskova, Hana Palova, Michal Mahdal, Lukas Pazourek, Petr Jabandziev, Ondrej Slaby, Peter Mudry, Jaroslav Sterba. Sci Rep. 2023 Jun 28;13(1):10499.
doi: 10.1038/s41598-023-37468-4. PMID: 37380669; PMCID: PMC10307862.
Desmocollin-1 is associated with pro-metastatic phenotype of luminal A breast cancer cells and is modulated by parthenolide. Petr Lapcik, Petr Sulc, Lucia Janacova, Katerina Jilkova, David Potesil, Pavla Bouchalova, Petr Müller, Pavel Bouchal Cell Mol Biol Lett. 2023 Aug 24;28(1):68.
doi: 10.1186/s11658-023-00481-6. PMID: 37620794; PMCID: PMC10464112.
Electrochemical biosensors for analysis of DNA point mutations in cancer research. Katerina Ondraskova, Ravery Sebuyoya, Ludmila Moranova, Jitka Holcakova, Petr Vonka, Roman Hrstka, Martin Bartosik. Anal Bioanal Chem. 2023 Mar;415(6):1065-1085.
doi: 10.1007/s00216-022-04388-7. PMID: 36289102.
Expression dynamics of metalloproteinases during mandibular bone formation: association with Myb transcription factor. Varadinkova S, Oralova V, Clarke M, Frampton J, Knopfova L, Lesot H, Bartos P, Matalova E. Front Cell Dev Biol. 2023 Aug 28;11:1168866.
doi: 10.3389/fcell.2023.1168866. PMID: 37701782; PMCID: PMC10493412.
In-depth analysis of biocatalysts by microfluidics: An emerging source of data for machine learning. Michal Vasina, David Kovar, Jiri Damborsky, Yun Ding, Tianjin Yang, Andrew deMello, Stanislav Mazurenko, Stavros Stavrakis, Zbynek Prokop. Biotechnol Adv. 2023 Sep;66:108171.
doi: 10.1016/j.biotechadv.2023.108171. PMID: 37150331.
Lysin (K)-specific demethylase 1 inhibition enhances proteasome inhibitor response and overcomes drug resistance in multiple myeloma. Cecilia Bandini, Elisabetta Mereu, Tina Paradzik, Maria Labrador, Monica Maccagno, Michela Cumerlato, Federico Oreglia, Lorenzo Prever, Veronica Manicardi, Elisa Taiana, Domenica Ronchetti, Mattia D'Agostino, Francesca Gay, Alessandra Larocca, Lenka Besse, Giorgio Roberto Merlo, Emilio Hirsch, Alessia Ciarrocchi, Giorgio Inghirami, Antonino Neri, Roberto Piva. Exp Hematol Oncol. 2023 Aug 10;12(1):71.
doi: 10.1186/s40164-023-00434-x. PMID: 37563685; PMCID: PMC10413620.
Optimized procedure for high-throughput transcriptome profiling of small extracellular vesicles isolated from low volume serum samples. Petra Vychytilova-Faltejskova, Sara Vilmanova, Lucie Pifkova, Tina Catela Ivković, Marie Mᶏdrzyk, Robin Jugas, Tana Machackova, Jan Kotoucek, Milana Sachlova, Lucia Bohovicova, Teodor Stanek, Jana Halamkova, Igor Kiss, Ondrej Slaby. Clin Chem Lab Med. 2023 Jul 31;62(1):157-167.
doi: 10.1515/cclm-2023-0610. PMID: 37505924.
pyCaverDock: Python implementation of the popular tool for analysis of ligand transport with advanced caching and batch calculation support. Ondrej Vavra, Jakub Beranek, Jan Stourac, Martin Surkovsky, Jiri Filipovic , Jiri Damborsky, Jan Martinovic, David Bednar. Bioinformatics. 2023 Aug 1;39(8):btad443.
doi: 10.1093/bioinformatics/btad443. PMID: 37471591; PMCID: PMC10397418.
SBILib: a handle for protein modeling and engineering. Patrick Gohl, Jaume Bonet, Oriol Fornes, Joan Planas-Iglesias, Narcís Fernandez-Fuentes, Baldo Oliva. Bioinformatics. 2023 Oct 3;39(10):btad613.
doi: 10.1093/bioinformatics/btad613. PMID: 37796837; PMCID: PMC10589914.
Tumor Cell-Intrinsic c-Myb Upregulation Stimulates Antitumor Immunity in a Murine Colorectal Cancer Model. Merel van Gogh, Jesus F Glaus Garzon, Dilara Sahin, Lucia Knopfova, Petr Benes, Onur Boyman, Igor Jurisica, Lubor Borsig. Cancer Immunol Res. 2023 Oct 4;11(10):1432-1444.
doi: 10.1158/2326-6066.CIR-22-0912. PMID: 37478172; PMCID: PMC10548106.
Molecular portraits of colorectal cancer morphological regions. Eva Budinská, Martina Hrivňáková, Tina Catela Ivkovic, Marie Madrzyk, Rudolf Nenutil, Beatrix Bencsiková, Dagmar Al Tukmachi, Michaela Ručková, Lenka Zdražilová Dubská, Ondřej Slabý, Josef Feit, Mihnea-Paul Dragomir, Petra Borilova Linhartova, Sabine Tejpar, Vlad Popovici. Elife. 2023 Nov 13;12:RP86655.
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MiR-4649-5p acts as a tumor-suppressive microRNA in triple negative breast cancer by direct interaction with PIP5K1C, thereby potentiating growth-inhibitory effects of the AKT inhibitor capivasertib. Katharina Jonas, Felix Prinz, Manuela Ferracin, Katarina Krajina, Barbara Pasculli, Alexander Deutsch, Tobias Madl, Beate Rinner, Ondrej Slaby, Christiane Klec, Martin Pichler. Breast Cancer Res. 2023 Oct 6;25(1):119.
doi: 10.1186/s13058-023-01716-2. PMID: 37803350; PMCID: PMC10559525.
Disclosing quantitative RT-PCR raw data during manuscript submission: a call for action. Andreas Untergasser, Jan Hellemans, Michael W Pfaffl, Jan M Ruijter, Maurice J B van den Hoff, Mihnea P Dragomir, Douglas Adamoski, Sandra Martha Gomes Dias, Rui Manuel Reis, Manuela Ferracin, Emmanuel Dias-Neto, Ian Marsh, Mikael Kubista, Muller Fabbri, Ajay Goel, Ondřej Slabý, Erik Knutsen, Baoqing Chen, Massimo Negrini, Koshi Mimori, Martin Pichler, Maria Papatriantafyllou, Simone Anfossi, Thomas D Schmittgen, Jim Huggett, Stephen Bustin, Jo Vandesompele, George A Calin; HEROIC (tHe initiativE gRoup On qRT dIsClosure) Consortium. Mol Oncol. 2023 May;17(5):713-717.
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Intestinal Paneth cell differentiation relies on asymmetric regulation of Wnt signaling by Daam1/2. Gabriele Colozza, Heetak Lee, Alessandra Merenda, Szu-Hsien Sam Wu, Andrea Català-Bordes, Tomasz W Radaszkiewicz, Ingrid Jordens, Ji-Hyun Lee, Aileen-Diane Bamford, Fiona Farnhammer, Teck Yew Low, Madelon M Maurice, Vítězslav Bryja, Jihoon Kim, Bon-Kyoung Koo. Sci Adv. 2023 Nov 24;9(47):eadh9673.
doi: 10.1126/sciadv.adh9673. PMID: 38000028; PMCID: PMC10672176.
Spatiotemporal monitoring of hard tissue development reveals unknown features of tooth and bone development. Marcos Gonzalez Lopez, Barbora Huteckova, Josef Lavicky, Nikodem Zezula, Vladislav Rakultsev, Vendula Fridrichova, Haneen Tuaima, Cita Nottmeier, Julian Petersen, Michaela Kavkova, Tomas Zikmund, Jozef Kaiser, Rupali Lav, Haza Star, Vítězslav Bryja, Petr Henyš, Miroslav Vořechovský, Abigail S Tucker, Jakub Harnos, Marcela Buchtova, Jan Krivanek. Sci Adv. 2023 Aug 2;9(31):eadi0482.
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High-dose aciclovir in CMV infection prophylaxis after allogeneic HSCT: a single-center long-term experience. Tomáš Kabut, Barbora Weinbergerová, František Folber, Martina Lengerová, Jiří Mayer. Bone Marrow Transplant. 2023 Nov;58(11):1229-1236.
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Different prognostic impact of recurrent gene mutations in chronic lymphocytic leukemia depending on IGHV gene somatic hypermutation status: a study by ERIC in HARMONY. Larry Mansouri, Birna Thorvaldsdottir, Lesley-Ann Sutton, Georgios Karakatsoulis, Manja Meggendorfer, Helen Parker, Ferran Nadeu, Christian Brieghel, Stamatia Laidou, Riccardo Moia, Davide Rossi, Mark Catherwood, Jana Kotaskova, Julio Delgado, Ana E Rodríguez-Vicente, Rocío Benito, Gian Matteo Rigolin, Silvia Bonfiglio, Lydia Scarfo, Mattias Mattsson, Zadie Davis, Ajay Gogia, Lata Rani, Panagiotis Baliakas, Hassan Foroughi-Asl, Cecilia Jylhä, Aron Skaftason, Inmaculada Rapado, Fatima Miras, Joaquín Martinez-Lopez, Javier de la Serna, Jesús María Hernández Rivas, Patrick Thornton, María José Larráyoz, María José Calasanz, Viktória Fésüs, Zoltán Mátrai, Csaba Bödör, Karin E Smedby, Blanca Espinet, Anna Puiggros, Ritu Gupta, Lars Bullinger, Francesc Bosch, Bárbara Tazón-Vega, Fanny Baran-Marszak, David Oscier, Florence Nguyen-Khac, Thorsten Zenz, Maria Jose Terol, Antonio Cuneo, María Hernández-Sánchez, Sarka Pospisilova, Ken Mills, Gianluca Gaidano, Carsten U Niemann, Elias Campo, Jonathan C Strefford, Paolo Ghia, Kostas Stamatopoulos, Richard Rosenquist. Leukemia. 2023 Feb;37(2):339-347.
doi: 10.1038/s41375-022-01802-y. PMID: 36566271; PMCID: PMC9898037.
Infrared Laser Desorption of Intact Nanoparticles for Digital Tissue Imaging. Marek Stiborek, Lenka Jindřichová, Stanislava Meliorisová, Antonín Bednařík, Vadym Prysiazhnyi, Jiří Kroupa, Pavel Houška, Barbora Adamová, Jarmila Navrátilová, Viktor Kanický, Jan Preisler. Anal Chem. 2022 Dec 27;94(51):18114-18120.
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Serum concentrations of proinflammatory biomarker interleukin-6 (IL-6) as a predictor of postoperative complications after elective colorectal surgery. Vladimír Procházka, Lukáš Lacina, Karel Smetana Jr, Martin Svoboda, Kateřina Skřivanová, Miroslava Beňovská, Jiří Jarkovský, Leoš Křen, Zdeněk Kala. World J Surg Oncol. 2023 Dec 14;21(1):384.
doi: 10.1186/s12957-023-03270-9. PMID: 38098074; PMCID: PMC10720211.
Molecular interactions of adaptor protein PSTPIP2 control neutrophil-mediated responses leading to autoinflammation. Nataliia Pavliuchenko, Iris Duric, Jarmila Kralova, Matej Fabisik, Frantisek Spoutil, Jan Prochazka, Petr Kasparek, Jana Pokorna, Tereza Skopcova, Radislav Sedlacek, Tomas Brdicka. Front Immunol. 2022 Dec 20;13:1035226.
doi: 10.3389/fimmu.2022.1035226. PMID: 36605205; PMCID: PMC9807597.
A patent review of cyclin-dependent kinase 7 (CDK7) inhibitors (2018-2022). Marketa Kovalová, Joseph Peter Baraka, Václav Mik, Radek Jorda, Lei Luo, Hao Shao, Vladimír Kryštof. Expert Opin Ther Pat. 2023 Feb;33(2):67-87.
doi: 10.1080/13543776.2023.2195547. PMID: 36975020
Active eosinophils regulate host defence and immune responses in colitis. Alessandra Gurtner, Costanza Borrelli, Ignacio Gonzalez-Perez, Karsten Bach, Ilhan E Acar, Nicolás G Núñez, Daniel Crepaz, Kristina Handler, Vivian P Vu, Atefeh Lafzi, Kristin Stirm, Deeksha Raju, Julia Gschwend, Konrad Basler, Christoph Schneider, Emma Slack, Tomas Valenta, Burkhard Becher, Philippe Krebs, Andreas E Moor, Isabelle C Arnold. Nature 2023, 615(7950):151-157.
doi: 10.1038/s41586-022-05628-7. PMID: 36509106
AMACR Expression is a Potential Diagnostic Marker in Apocrine Lesions of Breast, and is Associated with High Histologic Grade and Lymph Node Metastases in Some Invasive Apocrine Breast Cancers. Gabriel Lerner, Haiming Tang, Kamaljeet Singh, Reza Golestani, Samantha St Claire, Peter A Humphrey, Donald Lannin, Radoslav Janostiak, Malini Harigopal. Clin Breast Cancer. 2023 Feb;23(2):199-210.
doi: 10.1016/j.clbc.2022.11.012. PMID: 36577560
A-ring-fused pyrazoles of dihydrotestosterone targeting prostate cancer cells via the downregulation of the androgen receptor. Miroslav Peřina, Márton A Kiss, Gergo Motoyán, Eva Szczyrbová, Martin Eliáš, Vladimír Študent Jr, Daniela Kurfurstová, Markéta Kovalová, Lukáš Mada, Jan Bouchal, Eva Frank, Radek Jorda. Eur J Med Chem. 2023 Mar 5;249:115086.
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Cannabis-derived products antagonize platinum drugs by altered cellular transport. Tereza Buchtová, Lucie Beresova, Katarina Chromá, Tomáš Pluhacek, Tibor Beres, Dominika Kaczorova, Petr Tarkowski, Jiri Bartek, Martin Mistrík. Biomed Pharmacother. 2023 May 1;163:114801.
doi: 10.1016/j.biopha.2023.114801. PMID: 37137184
Circulating tumor nucleic acids: biology, release mechanisms, and clinical relevance. Pavel Stejskal, Hani Goodarzi, Josef Srovnal, Marián Hajdúch, Laura J vant Veer, Mark Jesus M Magbanua. Mol Cancer. 2023 Jan 21;22(1):15.
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Clinical lipidomics in the era of the big data. Aleš Kvasnička, Lukáš Najdekr, Dana Dobešová, Barbora Piskláková, Eliška Ivanovová, David Friedecký. Clin Chem Lab Med. 2023 Jan 4;61(4):587-598.
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Clonal origin and development of high hyperdiploidy in childhood acute lymphoblastic leukaemia. Eleanor L Woodward, Minjun Yang, Larissa H Moura-Castro, Hilda van den Bos, Rebeqa Gunnarsson Linda Olsson-Arvidsson, Diana C J Spierings, Anders Castor, Nicolas Duployez, Marketa Zaliova, Jan Zuna, Bertil Johansson, Floris Foijer, Kajsa Paulsson. Nat Commun. 2023 Mar 25;14(1):1658.
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Constitutively active Lyn kinase causes a cutaneous small vessel vasculitis and liver fibrosis syndrome. Adriana A de Jesus, Guibin Chen, Dan Yang, Tomas Brdicka, Natasha M Ruth, David Bennin, Dita Cebecauerova, Hana Malcova, Helen Freeman, Neil Martin, Karel Svojgr, Murray H Passo, Farzana Bhuyan, Sara Alehashemi, Andre T Rastegar, Katsiaryna Uss, Lela Kardava, Bernadette Marrero, Iris Duric, Ebun Omoyinmi, Petra Peldova, Chyi-Chia Richard Lee, David E Kleiner, Colleen M Hadigan, Stephen M Hewitt, Stefania Pittaluga, Carmelo Carmona-Rivera, Katherine R Calvo, Nirali Shah, Miroslava Balascakova, Danielle L Fink, Radana Kotalova, Zuzana Parackova, Lucie Peterkova, Daniela Kuzilkova, Vit Campr, Lucie Sramkova, Angelique Biancotto, Stephen R Brooks, Cameron Manes, Eric Meffre, Rebecca L Harper, Hyesun Kuehn, Mariana J Kaplan, Paul Brogan, Sergio D Rosenzweig, Melinda Merchant, Zuoming Deng, Anna Huttenlocher, Susan L Moir, Douglas B Kuhns, Manfred Boehm, Karolina Skvarova Kramarzova, Raphaela Goldbach-Mansky. Nat Commun. 2023 Mar 17;14(1):1502.
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Cytoplasmic Tail of MT1-MMP: A Hub of MT1-MMP Regulation and Function. Katerina Strouhalova, Ondřej Tolde, Daniel Rosel, Jan Brábek. Int J Mol Sci 2023 Mar 7;24(6):5068.
doi: 10.3390/ijms24065068. PMID: 36982142
Cytotoxicity evaluation of photosensitizer-conjugated hexagonal upconverting nanoparticles. Mykhailo Nahorniak, Viktoriia Oleksa, Taras Vasylyshyn, Ognen Pop-Georgievski, Eliška Rydvalová, Marcela Filipová, Daniel Horák. Nanomaterials 2023. Roč. 13, č. 9, č. článku 1535.
doi: 10.3390/nano13091535. PMCID: PMC10180129
Design, Synthesis, Biological Evaluation, and Crystallographic Study of Novel Purine Nucleoside Phosphorylase Inhibitors. Jan Skácel, Stefan Djukic, Ondřej Baszczyňski, Filip Kalčic, Tadeáš Bílek, Karel Chalupský, Jaroslav Kozák, Alexandra Dvořáková, Eva Tloušt’ová, Zuzana Král’ová, Markéta Šmídková, Jan Voldřich, Michaela Rumlová, Petr Pachl, Jiří Brynda, Tereza Vučková, Milan Fábry, Jan Snášel, Iva Pichová, Pavlína Řezáčová, Helena Mertlíková-Kaiserová, Zlatko Janeba. Journal of Medicinal Chemistry, 2023.
doi: 10.1021/acs.jmedchem.2c02097. PMID: 37134237
DiaPASEF proteotype analysis indicates changes in cell growth and metabolic switch induced by caspase-9 inhibition in chondrogenic cells. Petr Lapcik, Barbora Vesela, David Potesil, Katerina Dadakova, Martina Zapletalova, Petr Benes, Pavel Bouchal, Eva Matalova. Proteomics, 00, e2200408.
doi: 10.1002/pmic.202200408. PMID: 36960851
Engine shutdown: migrastatic strategies and prevention of metastases. Martina Raudenská, Kateřina Petrláková, Tamara Juriňáková, Jindřiška Leischner Fialová, Michaela Fojtů, Milan Jakubek, Daniel Rösel, Jan Brábek, Michal Masařík. Trends in Cancer 2023, 9(4), 293.
doi: 10.1016/j.trecan.2023.01.001. PMID: 36804341
Evaluation of linear versus star-like polymer anti-cancer nanomedicines in mouse models. Libor Kostka, Lenka Kotrchová, Eva Randárová, Carolina A. Ferreira, Iva Malátová, Hye Jin Lee, Aeli P. Olson, Jonathan W. Engle, Marek Kovář, Weibo Cai, Milada Šírová, Tomáš Etrych. Journal of Controlled Release. Roč. 353, January (2023), s. 549-562.
doi: 10.1016/j.jconrel.2022.11.060. PMID: 36470330
Expression of Selected miRNAs in Normal and Cancer-Associated Fibroblasts and in BxPc3 and MIA PaCa-2 Cell Lines of Pancreatic Ductal Adenocarcinoma. Václav Mandys, Alexey Popov, Robert Gürlich, Jan Havránek, Lucie Pfeiferová, Michal Kolář, Jana Vránová, Karel Smetana, Jr., Lukáš Lacina, Pavol Szabo. Int. J. Mol. Sci. 2023, 24(4), 3617.
doi: 10.3390/ijms24043617. PMID: 36835029
FoxP3 Expression in Tumor-Infiltrating Lymphocytes as Potential Predictor of Response to Immune Checkpoint Inhibitors in Patients with Advanced Melanoma and Non-Small Cell Lung Cancer. Peter Grell, Simona Borilova, Pavel Fabian, Iveta Selingerova, David Novak, Petr Muller, Igor Kiss, Rostislav Vyzula. Cancers 2023;15(6):1901.
doi: 10.3390/cancers15061901. PMID: 36980787; PMCID: PMC10047850
HPMA copolymer conjugated 5-aminolevulinic acid exhibits superior efficacy for photodynamic therapy with tumor-responsive and targeting properties. Rayhanul Islam, Kevin Kotalík, Vladimír Šubr, Shanghui Gao, Jian-Rong Zhou, Kazumi Yokomizo, Tomáš Etrych, Jun Fang. Nanomedicine: Nanotechnology, Biology and Medicine 2023. Roč. 48, č. článku 102636.
doi: 10.1016/j.nano.2022.102636. PMID: 36549553
Characterization of new highly selective pyrazolo[4,3-d]pyrimidine inhibitor of CDK7. Markéta Kovalová, Libor Havlíček, Stefan Djukic, Jana Škerlová, Miroslav Peřina, Tomáš Pospíšil, Eva Řezníčková, Pavlína Řezáčová, Radek Jorda, Vladimír Kryštof. Biomedicine & Pharmacotherapy, 2023, 161: 114492.
doi: 10.1016/j.biopha.2023.114492. PMID: 36931035
Chromatin Remodeling Enzyme Snf2h Is Essential for Retinal Cell Proliferation and Photoreceptor Maintenance. Andrea Kuzelova, Naoko Dupacova, Barbora Antosova, Sweetu Susan Sunny, Zbynek Kozmik, Jr., Jan Paces, Arthur I. Skoultchi, Tomas Stopka, and Zbynek Kozmik. 2023. Cells 12, no. 7: 1035.
doi: 10.3390/cells12071035. PMID: 37048108; PMCID: PMC10093269
Identification of AGR2 Gene-Specific Expression Patterns Associated with Epithelial-Mesenchymal Transition. Andrea Martisova, Lucia Sommerova, Adam Krejci, Iveta Selingerova, Tamara Kolarova, Filip Zavadil Kokas, Milos Holanek, Jan Podhorec, Tomas Kazda, Roman Hrstka. Int J Mol Sci. 2022 Sep 16;23(18):10845.
doi: 10.3390/ijms231810845. PMID: 36142758; PMCID: PMC9504245
Importance of Germline and Somatic Alterations in Human MRE11, RAD50, and NBN Genes Coding for MRN Complex. Barbora Otahalova, Zuzana Volkova, Jana Soukupova, Petra Kleiblova, Marketa Janatova, Michal Vocka, Libor Macurek, Zdenek Kleibl. Int J Mol Sci. 2023;24(6):5612.
doi: 10.3390/ijms24065612. PMID: 36982687
Long-term survival trends in solid cancers in the Nordic countries marking timing of improvements. Kari Jussi Hemminki, Asta Försti, Václav Liška, Anna Kanerva, Otto Hemminki, Akseli Hemminki. International Journal of Cancer 2023 May 1;152(9):1837-1846.
doi: 10.1002/ijc.34416. PMID: 36571455
Low Frequency of Cancer-Predisposition Gene Mutations in Liver Transplant Candidates with Hepatocellular Carcinoma. Klara Horackova, Sona Frankova, Petra Zemankova, Petr Nehasil, Marta Cerna, Magdalena Neroldova, Barbora Otahalova, Jan Kral, Milena Hovhannisyan, Viktor Stranecky, Tomas Zima, Marketa Safarikova, Marta Kalousova, Jan Novotny, Jan Sperl, Marianna Borecka, Sandra Jelinkova, Michal Vocka, Marketa Janatova, Petra Kleiblova, Zdenek Kleibl, Milan Jirsa, Jana Soukupova. Cancers (Basel). 2023 Dec 29;15(1):201.
doi: 10.3390/cancers15010201. PMID: 36612198
MicroRNA Profiling of Self-Renewing Human Neural Stem Cells Reveals Novel Sets of Differentially Expressed microRNAs During Neural Differentiation In Vitro. Veronika Fedorová, Kateřina Amruz Černá, Jan Oppelt, Veronika Pospíšilová, Tomáš Bárta, Marek Mraz, Dáša Bohačiaková. Stem Cell Rev and Rep (2023).
doi: 10.1007/s12015-023-10524-2. PMID: 36918496
Molecular Design of 68Ga- and 89Zr-labeled Anticalin radioligands for PET-imaging of PSMA-positive tumors. Volker Morath, Corinna Brandt, Friedrich-Christian Deuschle, Claudia T. Mendler, Claudia T. Mendler, Birgit Blechert, Dominik Summer, Cyril Barinka, Clemens Decristoforo, Wolfgang A. Weber, Markus Schwaiger, Arne Skerra. Mol. Pharmaceutics 2023,20(5), 2490-2501.
doi: 10.1021/acs.molpharmaceut.2c01066. PMID: 37068305
Molecular design, synthesis and anticancer activity of new thiopyrano[2,3-d]thiazoles based on 5-hydroxy-1,4-naphthoquinone (juglone). Iryna Ivasechko, Andrii Lozynskyi, Julia Senkiv, Piotr Roszczecko, Yuliia Kozak, Nataliya Finiuk, Olga Kluyuchivka, Nataliya Kashchak, Nazar Manko, Zvenyslava Maslyak, Daylo Lesyk, Andriy Karkhut, Svyatoslav Polovkovych, Robert Czarnomysy, Olga Szewczyk, Andriy Kozytskiy, Olexandr Karpenko, Dmytro Khyluk, Andzej Gzella, Krzysztof Bielawski, Anna Bielawska, Petr Dzubak, Sona Gurska, Marian Hajduch, Rostyslav Stoika, Roman Lesyk. Eur J Med Chem. 2023 Apr 5;252:115304.
doi: 10.1016/j.ejmech.2023.115304. PMID: 37001390
Ovarian cancer pathology characteristics as predictors of variant pathogenicity in BRCA1 and BRCA2. Denise G O'Mahony, Susan J Ramus, Melissa C Southey, Nicola S Meagher, Andreas Hadjisavvas, Esther M John, Ute Hamann, Evgeny N Imyanitov, Irene L Andrulis, Priyanka Sharma, Mary B Daly, Christopher R Hake, Jeffrey N Weitzel, Anna Jakubowska, Andrew K Godwin, Adalgeir Arason, Anita Bane, Jacques Simard, Penny Soucy, Maria A Caligo, Phuong L Mai, Kathleen B M Claes, Manuel R Teixeira, Wendy K Chung, Conxi Lazaro, Peter J Hulick, Amanda E Toland, Inge Sokilde Pedersen; HEBON Investigators; Susan L Neuhausen, Ana Vega, Miguel de la Hoya, Heli Nevanlinna, Mallika Dhawan, Valentina Zampiga, Rita Danesi, Liliana Varesco, Viviana Gismondi, Valerio Gaetano Vellone, Paul A James, Ramunas Janavicius, Liene Nikitina-Zake, Finn Cilius Nielsen, Thomas van Overeem Hansen, Tanja Pejovic, Ake Borg, Johanna Rantala, Kenneth Offit, Marco Montagna, Katherine L Nathanson, Susan M Domchek, Ana Osorio, María J García, Beth Y Karlan; GEMO Study Collaborators; Anna De Fazio, David Bowtell; AOCS Group; Lesley McGuffog, Goska Leslie, Michael T Parsons, Thilo Dörk, Lisa-Marie Speith, Elizabeth Santana Dos Santos, Alexandre André B A da Costa, Paolo Radice, Paolo Peterlongo, Laura Papi, Christoph Engel, Eric Hahnen, Rita K Schmutzler, Barbara Wappenschmidt, Douglas F Easton, Marc Tischkowitz, Christian F Singer, Yen Yen Tan, Alice S Whittemore, Weiva Sieh, James D Brenton, Drakoulis Yannoukakos, Florentia Fostira, Irene Konstantopoulou, Jana Soukupova, Michal Vocka; CZECANCA Consortium; Georgia Chenevix-Trench, Paul D P Pharoah, Antonis C Antoniou, David E Goldgar, Amanda B Spurdle, Kyriaki Michailidou; Consortium of Investigators of Modifiers of BRCA1/2; Evidence-based Network for the Interpretation of Germline Mutant Alleles Consortium. Br J Cancer. 2023 Apr 19. Online ahead of print.
doi: 10.1038/s41416-023-02263-5. PMID: 37076566
Personal comorbidities and their subsequent risks for liver, gallbladder and bile duct cancers. Kari Jussi Hemminki, Kristina Sundquist, Jan Sundquist, Asta Försti, Václav Liška, Akseli Hemminki, Xinjun Li. International Journal of Cancer 2023 Mar 15;152(6):1107-1114.
doi: 10.1002/ijc.34308. PMID: 36196489
Perspectives in the Application of High, Medium, and Low Molecular Weight Oat β-d-Glucans in Dietary Nutrition and Food Technology—A Short Overview. Leonid Sushytskyi, Andriy Synytsya, Jana Čopíková, Pavol Lukáč, Lenka Rajsiglová, Paolo Tenti, and Luca E. Vannucci. Foods 2023, 12, no. 6: 1121.
doi: 10.3390/foods12061121. PMID: 36981048; PMCID: PMC10048208
Phosphorylation of TRF2 promotes its interaction with TIN2 and regulates DNA damage response at telomeres. Radka Storchova, Matous Palek, Natalie Palkova, Pavel Veverka, Tomas Brom, Ctirad Hofr, Libor Macurek. Nucleic Acids Research. 2023; 51(3):1154-1172.
doi: 10.1093/nar/gkac1269. PMID: 36651296
PPM1D activity promotes the replication stress caused by cyclin E1 overexpression. Andra S. Martinikova, Miroslav Stoyanov, Anna Oravetzova, Yannik Kok, Sonbin Yu, Jana Dobrovolna, Pavel Janscak, Marcel van Vugt, Libor Macurek. Molecular Oncology. 2023 (E-pub ahead of print)
doi: 10.1002/1878-0261.13433. PMID: 37067201
Recent Advances in Methods for Circulating Tumor Cell Detection. Monika Vidlářová, Alona Řehulková, Pavel Stejskal, Andrea Prokopova, Hanus Slavik. Marián Hajdúch, Josef Srovnal. Int J Mol Sci. 2023 Feb 15;24(4):3902.
doi: 10.3390/ijms24043902. PMID: 36835311
Selectivity of Hydroxamate- and Difluoromethyloxadiazole-Based Inhibitors of Histone Deacetylase 6 In Vitro and in Cells. Jakub Ptacek, Ivan Snajdr, Jiri Schimer, Zsofia Kutil, Jana Mikesova, Petra Baranova, Barbora Havlinova, Werner Tueckmantel, Pavel Majer, Alan Kozikowski, Cyril Barinka. Int. J. Mol. Sci. 2023, 24, 4720.
doi: 10.3390/ijms24054720. PMID: 36902164
The emerging role of microtubules in invasion plasticity. Anna Legátová, Markéta Pelantová, Daniel Rösel, Jan Brábek, Aneta Škarková. Front Oncol. 2023 Feb 13;13:1118171.
doi: 10.3389/fonc.2023.1118171. PMID: 36860323; PMCID: PMC9969133
The KMT2A recombinome of acute leukemias in 2023. C Meyer, P Larghero, B Almeida Lopes, T Burmeister, D Gröger, R Sutton, N C Venn, G Cazzaniga, L Corral Abascal, G Tsaur, L Fechina, M Emerenciano, M S Pombo-de-Oliveira, T Lund-Aho, T Lundán, M Montonen, V Juvonen, J Zuna, J Trka, P Ballerini, H Lapillonne, V H J Van der Velden, E Sonneveld, E Delabesse, R R C de Matos, M L M Silva, S Bomken, K Katsibardi, M Keernik, N Grardel, J Mason, R Price, J Kim, C Eckert, L Lo Nigro, C Bueno, P Menendez, U Zur Stadt, P Gameiro, L Sedék, T Szczepański, A Bidet, V Marcu, K Shichrur, S Izraeli, H O Madsen, B W Schäfer, S Kubetzko, R Kim, E Clappier, H Trautmann, M Brüggemann, P Archer, J Hancock, J Alten, A Möricke, M Stanulla, J Lentes, A K Bergmann, S Strehl, S Köhrer, K Nebral, M N Dworzak, O A Haas, C Arfeuille, A Caye-Eude, H Cavé, R Marschalek. Leukemia. 2023 May;37(5):988-1005.
doi: 10.1038/s41375-023-01877-1. PMID: 37019990; PMCID: PMC10169636
Therapeutic Potential and Limitations of Curcumin as Antimetastatic Agent. Petr Dytrych, Zdeněk Kejík, Jan Hajduch, Robert Kaplánek, Kateřina Veselá, Kateřina Kučnirová, Markéta Skaličková, Anna Venhauerová, David Hoskovec, Pavel Martásek, Milan Jakubek. Biomedicine and Pharmacotherapy 2023,163, 114758.
doi: 10.1016/j.biopha.2023.114758. PMID: 37141738
Triazole-based estradiol dimers prepared via CuAAC from 17α-ethinyl estradiol with five-atom linkers causing G2/M arrest and tubulin inhibition. Michal Jurášek, Jiří Řehulka, Lenka Hrubá, Aleksandra Ivanová, Soňa Gurská, Olena Mokshna, Pavel Trousil, Lukáš Huml, Pavel Polischchuk Marián Hajdúch, Pavel B Drašar, Petr Džubák. Bioorg Chem. 2023 Feb; 131:106334.
doi: 10.1016/j.bioorg.2022.106334. PMID: 36592487
Tunable Multivalent Platform for Immune Recruitment to Lower Antigen Expressing Cancers. Benjamin P M Lake, Ryan G Wylie, Cyril Bařinka, Anthony F Rullo. Angew Chem Int Ed Engl 2023, 62(9).
doi: 10.1002/anie.202214659. PMID: 36577087
2022
Developmental changes in iron metabolism and erythropoiesis in mice with human gain-of-function erythropoietin receptor. Barbora Kralova, Lucie Sochorcova, Jihyun Song, Ondrej Jahoda, Katarina Hlusickova Kapralova, Josef T Prchal, Vladimir Divoky, Monika Horvathova. Am J Hematol. 2022 Oct;97(10):1286-1299.
doi: 10.1002/ajh.26658. PMID: 35815815
Thiosemicarbazones Can Act Synergistically with Anthracyclines to Downregulate CHEK1 Expression and Induce DNA Damage in Cell Lines Derived from Pediatric Solid Tumors. Silvia Paukovčeková, Maria Krchniakova, Petr Chlapek, Jakub Neradil, Jan Škoda, Renata Veselská. Int J Mol Sci 2022 Aug 1;23(15):8549.
doi: 10.3390/ijms23158549. PMID: 35955683; PMCID: PMC9369312
Fully automated virtual screening pipeline of FDA-approved drugs using Caver Web. Miloš Musil, Andrej Ježík, Marie Jankůjová, Jan Štourač, Jakub Galgonek, Saltuk Mustafa Eyrilmez, Jiří Vondrášek, Jiří Damborský, David Bednář. Comput Struct Biotechnol J. 2022, Nov 17;20:6512-6518.
doi: 10.1016/j.csbj.2022.11.031. PMID: 36467577; PMCID: PMC9705369
Current methods for studying metastatic potential of tumor cells. Pavla Bouchalová, Pavel Bouchal. Cancer Cell Int. 2022 Dec 9;22(1):394.
doi: 10.1186/s12935-022-02801-w. PMID: 36494720; PMCID: PMC9733110
The landscape of tumor cell states and spatial organization in H3-K27M mutant diffuse midline glioma across age and location. Ilon Liu, Li Jiang, Erik R Samuelsson, Sergio Marco Salas, Alexander Beck, Olivia A Hack, Daeun Jeong, McKenzie L Shaw, Bernhard Englinger, Jenna LaBelle, Hafsa M Mire, Sibylle Madlener, Lisa Mayr, Michael A Quezada, Maria Trissal, Eshini Panditharatna, Kati J Ernst, Jayne Vogelzang, Taylor A Gatesman, Matthew E Halbert, Hana Pálová, Petra Pokorná, Jaroslav Štěrba, Ondřej Slabý, Rene Geyeregger, Aaron Diaz, Izac J Findlay, Matthew D Dun, Adam Resnick, Mario L Suvà, David T W Jones, Sameer Agnihotri, Jessica Svedlund, Carl Koschmann, Christine Haberler, Thomas Czech, Irene Slavc, Jennifer A Cotter, Keith L Ligon, Sanda Alexandrescu, W K Alfred Yung, Isabel Arrillaga-Romany, Johannes Gojo, Michelle Monje, Mats Nilsson, Mariella G Filbin. Nat Genet. 2022 Dec;54(12):1881-1894.
doi: 10.1038/s41588-022-01236-3. PMID: 36471067; PMCID: PMC9729116
Electrochemical DNA biosensor coupled to LAMP reaction for early diagnostics of cervical precancerous lesions. Ravery Sebuyoya, Ludmila Moráňová, Nasim Izadi, Roman Hrstka, Milan Anton, Martin Bartošík. Biosensors and Bioelectronics: X Volume 12, December 2022, 100224.
doi: 10.1016/j.biosx.2022.100224.
Electrochemical biosensors for analysis of DNA point mutations in cancer research. Kateřina Ondrášková, Ravery Sebuyoya, Ludmila Moráňová, Jitka Holčáková, Petr Voňka, Roman Hrstka, Martin Bartošík. Anal Bioanal Chem. 2023, Mar;415(6):1065-1085.
doi: 10.1007/s00216-022-04388-7 PMID: 36289102
Modulating the pharmacokinetic profile of Actinium-225-labeled macropa-derived radioconjugates by dual targeting of PSMA and albumin. Falco Reissig, Kristof Zarschler, Zbyněk Nový, Miloš Petřík, Kateřina Bendová, Daniela Kurfürstová, Jan Bouchal, Marie Charlotte Ludik, Florian Brandt, Klaus Kopka, Marta Khoylou, Hans-Jürgen Pietzsch, Marián Hajdúch, Constantin Mamat. Theranostics 2022, Oct 17;12(17):7203-7215.
doi: 10.7150/thno.78043. PMID: 36438496; PMCID: PMC9691366
Characterization of drug effects on cell cultures from phase-contrast microscopy images. Denis Baručić, Sumit Kaushik, Jan Kybic, Jarmila Stanková, Petr Džubák, Marián Hajdúch.
Comput Biol Med 2022, Dec;151(Pt A):106171
doi: 10.1016/j.compbiomed.2022.106171. PMID: 36306582
Chronic inflammation decreases HSC fitness by activating the druggable Jak/Stat3 signaling pathway. Srđan Grušanović, Petr Daněk, Maria Kuzmina, Miroslava Kari Adamcová, Burócziová, Monika, Romana Mikyšková, Karolina Vaníčková, Slađana Kosanović, Jana Pokorná, Milan Reiniš, Tomáš Brdička, Meritxell Alberich Jordà. EMBO Rep. 2023, Jan 9;24(1):e54729.
doi: 10.15252/embr.202254729. PMID: 36341527; PMCID: PMC9827550
γ-Tubulin in microtubule nucleation and beyond. Vadym Sulimenko, Eduarda Dráberová, Pavel Dráber. Front Cell Dev Biol. 2022, Sep 1;10:880761.
doi: 10.3389/fcell.2022.880761. PMID: 36158181; PMCID: PMC9503634
Discovery of small molecule mechanistic target of rapamycin inhibitors as anti-aging and anti-cancer therapeutics. Žofia Chrienová, David Ryšánek, Patrik Olekšák, Dorota Starý, Marek Bajda, Milan Reiniš, Romana Mikyšková, Ondřej Novotný, Rudolf Andrýs, Adam Skarka, Pavla Vašicová, Josef Novák, Martin Vališ, Kamil Kuča, Zdeněk Hodný, Eugenie Nepovimová. Front Aging Neurosci. 2022 Dec 6;14:1048260.
doi: 10.3389/fnagi.2022.1048260. PMID: 36561137; PMCID: PMC9767416
Involvement of Small Non-Coding RNA and Cell Antigens in Pathogenesis of Extramedullary Multiple Myeloma. Monika Vlachová, Jana Gregorová, Petra Vychytilová-Faltejsková, Natalia Anna Gabło, Lenka Radová, Lenka Pospíšilová, Martina Almáši, Martin Štork, Zdenka Knechtová, Jiří Minařík, Tereza Popková, Tomáš Jelínek, Roman Hájek, Luděk Pour, Lucie Říhová, Sabina Ševčíková. Int J Mol Sci. 2022, Nov 25;23(23):14765.
doi: 10.3390/ijms232314765. PMID: 36499093; PMCID: PMC9741227
Unexpected Heterogeneity of Newly Diagnosed Multiple Myeloma Patients with Plasmacytomas. Martin Štork, Sabina Ševčíková, Tomáš Jelínek, Jiří Minařík, Jakub Radocha, Tomáš Pika, Lenka Pospíšilová, Ivan Špička, Jan Štraub, Petr Pavlíček, Alexandra Jungová, Zdeňka Knechtová, Viera Sandecká, Vladimír Maisnar, Roman Hájek, Luděk Pour.
Biomedicines 2022, 10(10), 2535.
doi: 10.3390/biomedicines10102535. PMID: 36289797; PMCID: PMC9599767
More Than 2% of Circulating Tumor Plasma Cells Defines Plasma Cell Leukemia–Like Multiple Myeloma. Tomáš Jelínek, Renata Bezděková, David Žihala, Tereza Ševčíková, Anjana Anilkumar Sithara, Lenka Pospíšlová, Sabina Ševčíková, Petra Poláčková, Martin Štork, Zdeňka Knechtová, Ondřej Venglář, Veronika Kapustová, Tereza Popková, Ludmila Muroňová, Zuzana Chyra, Matouš Hrdinka, Michal Šimíček, Juan-Jose Garcés, Noemi Puig, Maria-Teresa Cedena, Artur Jurczyszyn, Jorge J Castillo, Miroslav Penka, Jakub Radocha, María Victoria Mateos, Jesús San Miguel, Bruno Paiva, Luděk Pour, Lucie Říhová, Roman Hájek. J Clin Oncol. 2022, Oct 31;JCO2201226.
doi: 10.1200/JCO.22.01226. PMID: 36315921
Distinct p53 phosphorylation patterns in chroniclymphocytic leukemia patients are reflected in theactivation of circumjacent pathways upon DNA damage. Veronika Mančíková, Michaela Pešová, Šárka Pavlová, Robert Helma, Kristýna Zavácká, Václav Hejret, Petr Taus, Jakub Hynšt, Karla Plevová, Jitka Malčíková, Šarka Pospíšilová. Mol. Oncol. 2023, Jan;17(1):82-97.
doi: 10.1002/1878-0261.13337. PMID: 36334078; PMCID: PMC9812841
Thiosemicarbazones and selected tyrosine kinase inhibitors synergize in pediatric solid tumors: NDRG1 upregulation and impaired prosurvival signaling in neuroblastoma cells. Maria Krchniakova, Silvia Paukovčeková, Petr Chlapek, Jakub Neradil, Jan Škoda, Renata Veselská. Front Pharmacol. 2022 Sep 7;13:976955.
doi: 10.3389/fphar.2022.976955. PMID: 36160437; PMCID: PMC9490180
Disulfriam increases the efficiency of 5-fluorouracil in organotypic cultures of colorectal carcinoma. Michal Hendrych, Kamila Říhová, Barbora Adamová, Vojtěch Hradil, Marek Stiborek, Petr Vlček, Markéta Hermanová, Jana Vašíčková, Petr Beneš, Jan Šmarda, Viktor Kanický, Jan Preisler, Jarmila Navrátilová. Biomed Pharmacother 2022, Sep;153:113465.
doi: 10.1016/j.biopha.2022.113465. PMID: 36076577
SoluProtMutDB: A manually curated database of protein solubility changes upon mutations. Jan Velecký, Marie Hamšíková, Jan Šťourač, Miloš Musil, Jiří Damborský, David Bednář, Stanislav Mazurenko. Comput Struct Biotechnol J. 2022, Nov 9;20:6339-6347.
doi: 10.1016/j.csbj.2022.11.009. PMID: 36420168; PMCID: PMC9678803
Minimal residual disease in BCR: ABL1-positive acute lymphoblastic leukemia: different significance in typical ALL and in CML-like disease. Jan Zuna, Lenka Hovorková, Justina Krotká, Amelie Koehrmann, Michela Bardini, Lucie Winkowská, Eva Froňková, Julia Alten, Rolf Koehler, Cornelia Eckert, Lisa Brizzolara, Marie Trková, Jan Stuchlý, Martin Zimmermann, Paola De Lorenzo, Maria Grazia Valsecchi, Valentino Conter, Jan Starý, Martin Schrappe, Andrea Biondi, Jan Trka, Markéta Žaliová, Giovanni Cazzaniga, Gunnar Cario.
Leukemia volume 36, pages 2793–2801 (2022).
doi: 10.1038/s41375-022-01668-0. PMID: 35933523
Long Non-Coding RNA and microRNA Interplay in Colorectal Cancer and Their Effect on the Tumor Microenvironment. Marie Rajtmajerová, Andriy Trailin, Václav Liška, Kari Jussi Hemminki, Filip Ambrozkiewicz. Cancers 2022, 14(21), 5450.
doi: 10.3390/cancers14215450. PMID: 36358867; PMCID: PMC9655812
Activated Hepatic Stellate Cells in Hepatocellular Carcinoma: Their Role as a Potential Target for Future Therapies. Esraa Ali, Andriy Trailin, Filip Ambrozkiewicz, Václav Liška, Kari Jussi Hemminki. Int. J. Mol. Sci. 2022, 23(23), 15292.
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LACTB exerts tumor suppressor properties in ovarian cancer through regulation of Slug. Valentina Cutano, Jessica Marianne Ferreira Mendes, Sara Escudeiro-Lopes, Susana Machado, Judith Vinaixa Forner, Juan M Gonzales-Morena, Martin Převorovský, Viacheslav Zemlianski, Yuxiong Feng, Petra Králová Viziová, Andrea Hartmanová, Beáta Malčeková, Pavel Jakoubě, Sonia Iyer, Zuzana Kečkéšová. Life Sci Alliance. 2022 Nov 14;6(1):e202201510.
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TROP2 Represents a Negative Prognostic Factor in Colorectal Adenocarcinoma and Its Expression Is Associated with Features of Epithelial–Mesenchymal Transition and Invasiveness. Jiří Švec, Monika Šťastná, Lucie Janečková, Dušan Hrčkulák, Martina Vojtěchová, Jakub Onhajzer, Vítězslav Kříž, Kateřina Galušková, Eva Šloncová, Jan Kubovčiak, Lucie Pfeiferová, Jan Hrudka, Radoslav Matěj, Petr Waldauf, Lukáš Havlůj, Michal Kolář, Vladimír Kořínek. Cancers (Basel) 2022, Aug 26;14(17):4137.
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FBXO38 Ubiquitin Ligase Controls Centromere Integrity via ZXDA/B Stability. Nikol Dibus, Vladimír Kořínek, Lukáš Čermák. Front Cell Dev Biol. 2022 Jun 23;10:929288.
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NGS better discriminates true MRD positivity for the risk stratification of childhood ALL treated on MRD-based protocol. Michael Svatoň, Aneta Skotnicová, Leona Řezníčková, Andrea Rennerová, Taťána Valová, Michaela Kotrová, Vincent H J van der Velden, Monika Brüggemann, Nikos Darzentas, Anton W Langerak, Jan Zuna, Jan Starý, Jan Trka, Eva Froňková. Blood (2023) 141 (5): 529–533.
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Azulene hydrazide-hydrazones for selective targeting of pancreatic cancer cells. Tereza Brogyányi, Robert Kaplánek, Zdeněk Kejík, Božena Hosnedlová, Veronika Antonyová, Nikita Abramenko, Kateřina Veselá, Pavel Martásek, Martin Vokurka, Des R Richardson, Milan Jakubek. Biomedicine & Pharmacotherapy, 2022 Nov; 155:113736.
doi: 10.1016/j.biopha.2022.113736. PMID: 36156366
Restored biosynthetic pathways induced by MSCs serve as rescue mechanism in leukemia cells after L-asparaginase therapy. Natividad Alquezar-Artieda, Daniela Kužílková, Jennie Roberts, Katerina Hložková, Alena Pecinová, Petr Pecina, Martina Zwyrtková, Eliška Potůčková, Daniel Kavan, Ivana Hermanová, Markéta Žaliová, Petr Novák, Tomáš Mráček, Lucie Šrámková, Daniel A Tennant, Jan Trka, Júlia Starková. Blood Adv. 2022 Nov 18;bloodadvances.2021006431.
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Pentamethinium salts suppress key metastatic processes by regulating mitochondrial function and inhibiting dihydroorotate dehydrogenase respiration. Jindriška Leischner Fialová, Kateřina Hönigová, Martina Raudenská, Lucie Mikšátková, Renata Zobalová, Jiří Navrátil, Jana Šmigová, Taraka Ramji Moturu, Tomáš Vicar, Jan Balvan, Kateřina Veselá, Nikita Abramenko, Zdeněk Kejík, Robert Kaplánek, Jaromír Gumulec, Daniel Rosel, Pavel Martásek, Jan Brábek. Jiří Neužil, Michal Masařík. Biomedicine & Pharmacotherapy, 2022 Oct; 154:113582.
doi: 10.1016/j.biopha.2022.113582. PMID: 36055111
Complex genetic and histopathological study of 15 patient-derived xenografts of aggressive lymphomas. Radek Jakša, Jana Karolová, Michael Svatoň, Dmitry Kazantsev, Martina Grajciarová, Eva Pokorná, Zbyněk Tonar, Magdalena Klánová, Lucie Winkowska, Diana Maláriková, Petra Vočková, Kristina Forsterová, Nicol Renešová, Alexandra Dolníková, Kristýna Nožičková, Pavel Dundr, Eva Froňková, Marek Trněný, Pavel Klener. Laboratory Investigation, 2022 Sep; 102(9):957-965.
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Non-Psychotropic Cannabinoids as Inhibitors of TET1 Protein. Veronika Antonyová, Zdeněk Kejík, Tereza Brogyanyi, Robert Kaplánek, Kateřina Veselá, Nikita Abramenko, Tomáš Ocelka, Michal Masařík, Adam Matkowski, Jakub Gburek, Renata Abel, Andrean Goede, Robert Preissner, Petr Novotný, Milan Jakubek. Bioorganic Chemistry, 2022 Jul; 124:105793.
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Targeting of the Mitochondrial TET1 Protein by Pyrrolo[3,2-b]pyrrole Chelators. Veronika Antonyová, Ameneh Tatar, Tereza Brogyányi, Zdeněk Kejík, Robert Kaplánek, Fréderic Vellieux, Nikita Abramenko, Alla Sinica, Jan Hajduch, Petr Novotný, Bettie Sue Masters, Pavel Martásek, Milan Jakubek. Int. J. Mol. Sci, 2022 Sep; 16;23(18):10850.
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G-CSF plus azacitidine versus azacitidine alone for patients with high-risk myelodysplastic syndrome: academic, open label, randomized trial. Tomáš Stopka, Lubomír Minařík, Nina Dusílková, Michal Pešta, Vojtěch Kulvait, Martin Špaček, Zuzana Zemanová, Marta Kalousová, Anna Jonášová. Blood Cancer Journal, volume 12, article number: 105 (2022).
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Combined Approach to Leukemic Differentiation Using Transcription Factor PU.1-Enhancing Agents. Petra Bašová, Helena Paszeková, Lubomír Minařík, Martina Dluhošová, Pavel Burda, Tomáš Stopka. Int. J. Mol. Sci, 2022, Jun; 16;23(12):6729.
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Quaternized Chitosan/Heparin Polyelectrolyte Multilayer Films for Protein Delivery. Tomasz Urbaniak, Gabriela S. García-Briones, Alexander Zhigunov, Sviatoslav Hladysh, Edyta Adrian, Volodymyr Lobaz, Tereza Krunclová, Olga Janoušková, Ognen Pop-Georgievski, Dana Kubies. Biomacromolecules 2022, 23, 11, 4734–4748.
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New-Generation Heterocyclic Bis-Pentamethinium Salts as Potential Cytostatic Drugs with Dual IL-6R and Mitochondria-Targeting Activity. Veronika Talianová, Zdeněk Kejík, Robert Kaplánek, Kateřina Veselá, Nikita Abramenko, Lukáš Lacina, Karolína Strnadová, Barbora Dvořánková, Pavel Martásek, Michal Masařík, Magdalena Houdová Megová, Petr Bušek, Jana Křížová, Lucie Zdražilová, Hana Hansíková, Erik Vlčák, Vlada Filimonenko, Aleksi Šedo, Karel Smetana Jr, Milan Jakubek. Pharmaceutics 2022, 14(8), 1712.
doi: 10.3390/pharmaceutics14081712. PMID: 36015338
Biomarker Dynamics and Long-Term Treatment Outcomes in Breast Cancer Patients with Residual Cancer Burden after Neoadjuvant Therapy. Milos Holanek, Iveta Selingerova, Pavel Fabian, Oldrich Coufal, Ondrej Zapletal, Katarina Petrakova, Tomas Kazda, Roman Hrstka, Alexandr Poprach, Maria Zvarikova, Ondrej Bilek, Marek Svoboda. Diagnostics 2022, 12(7), 1740.
doi: 10.3390/diagnostics12071740. PMID: 35885644; PMCID: PMC9318288
Design, Synthesis, and Biochemical and Biological Evaluation of Novel 7-Deazapurine Cyclic Dinucleotide Analogues as STING Receptor Agonists. Zdeněk Vavřina, Pavla Perlíková, Nemanja Milisavljević, Florian Chevrier, Miroslav Smola, Joshua Smith, Milan Dejmek, Vojtěch Havlíček, Miloš Buděšínský, Radek Liboska, Lenka Vaneková, Jiří Brynda, Evzen Boura, Pavlína Řezáčová, Michal Hocek, and Gabriel Birkuš. J. Med. Chem.2022, 65, 20, 14082–14103.
doi: 10.1021/acs.jmedchem.2c01305. PMID: 36201304
Emetine blocks DNA replication via proteosynthesis inhibition not by targeting Okazaki fragments. David Lukac, Zuzana Machacova, Pavel Moudry. Life Sci Alliance. 2022 Sep 9;5(12):e202201560.
doi: 10.26508/lsa.202201560. PMID: 36260751; PMCID: PMC9463495
Synthesis of Polycyclic Hetero-Fused 7-Deazapurine Heterocycles and Nucleosides through C-H Dibenzothiophenation and Negishi Coupling. Chao Yang, Lenka Poštová Slavětínská, Marianne Fleuti, Blanka Klepetářová, Michal Tichý, Soňa Gurská, Petr Pavliš, Petr Džubák, Marián Hajdúch, Michal Hocek. J. Am. Chem. Soc. 2022, 144, 42, 19437–19446.
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Preparation, In Vitro Affinity, and In Vivo Biodistribution of Receptor-Specific Ga-Labeled Peptides Targeting Vascular Endothelial Growth Factor Receptors. Pavel Barta, Rajamanikkam Kamaraj, Monika Kucharova, Zbynek Novy, Milos Petrik, Katerina Bendova, Marian Hajduch, Petr Pavek, Frantisek Trejtnar. Bioconjugate Chem. 2022, 33, 10, 1825–1836.
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Modulation of FLT3-ITD and CDK9 in acute myeloid leukaemia cells by novel proteolysis targeting chimera (PROTAC). Eva Řezníčková, Soňa Krajčovičová, Miroslav Peřina, Markéta Kovalová, Miroslav Soural, Vladimír Kryštof. Europen Journal of Medicinal Chem. 2022, 243, 114792.
doi: 10.1016/j.ejmech.2022.114792. PMID: 36191408
Triterpenoid pyrazines and pyridines – Synthesis, cytotoxicity, mechanism of action, preparation of prodrugs. Jiří Hodoň, Ivo Frydrych, Zdeňka Trhlíková, Jan Pokorný, Lucie Borková, Sandra Benická, Martin Vlk, Barbora Lišková, Agáta Kubíčková, Martina Medvedíková, Martin Pisár, Jan Šarek, Viswanath Das, Anna Ligasová, Karel Koberna, Petr Džubák, Marián Hajdúch, Milan Urban. Europen Journal of Medicinal Chem. 2022, 243,114777.
doi: 10.1016/j.ejmech.2022.114777. PMID: 36174412
Mixture Effects of Tryptophan Intestinal Microbial Metabolites on Aryl Hydrocarbon Receptor Activity Aneta Vrzalová, Petra Pečinková, Peter Illés, Soňa Gurská, Petr Džubák, Martin Szotkowski, Marián Hajdúch, Sridhar Mani, Zdeněk Dvořák.
Int. J. Mol. Sci. 2022, 23 (18), 10825.
doi: 10.3390/ijms231810825. PMID: 36142735; PMCID: PMC9505659