Research institutions gathered in the NICR have committed themselves to create over 600 classifiable outputs, including over 400 academic publications. Here is an overview of works published in scientific journals belonging to the first quartile of the relevant science and of some other outputs of the project.
Thiosemicarbazones Can Act Synergistically with Anthracyclines to Downregulate CHEK1 Expression and Induce DNA Damage in Cell Lines Derived from Pediatric Solid Tumors. Silvia Paukovčeková, Maria Krchniakova, Petr Chlapek, Jakub Neradil, Jan Škoda, Renata Veselská. Int J Mol Sci 2022 Aug 1;23(15):8549.
doi: 10.3390/ijms23158549. PMID: 35955683; PMCID: PMC9369312
Fully automated virtual screening pipeline of FDA-approved drugs using Caver Web. Miloš Musil, Andrej Ježík, Marie Jankůjová, Jan Štourač, Jakub Galgonek, Saltuk Mustafa Eyrilmez, Jiří Vondrášek, Jiří Damborský, David Bednář. Comput Struct Biotechnol J. 2022, Nov 17;20:6512-6518.
doi: 10.1016/j.csbj.2022.11.031. PMID: 36467577; PMCID: PMC9705369
Current methods for studying metastatic potential of tumor cells. Pavla Bouchalová, Pavel Bouchal. Cancer Cell Int. 2022 Dec 9;22(1):394.
doi: 10.1186/s12935-022-02801-w. PMID: 36494720; PMCID: PMC9733110
The landscape of tumor cell states and spatial organization in H3-K27M mutant diffuse midline glioma across age and location. Ilon Liu, Li Jiang, Erik R Samuelsson, Sergio Marco Salas, Alexander Beck, Olivia A Hack, Daeun Jeong, McKenzie L Shaw, Bernhard Englinger, Jenna LaBelle, Hafsa M Mire, Sibylle Madlener, Lisa Mayr, Michael A Quezada, Maria Trissal, Eshini Panditharatna, Kati J Ernst, Jayne Vogelzang, Taylor A Gatesman, Matthew E Halbert, Hana Pálová, Petra Pokorná, Jaroslav Štěrba, Ondřej Slabý, Rene Geyeregger, Aaron Diaz, Izac J Findlay, Matthew D Dun, Adam Resnick, Mario L Suvà, David T W Jones, Sameer Agnihotri, Jessica Svedlund, Carl Koschmann, Christine Haberler, Thomas Czech, Irene Slavc, Jennifer A Cotter, Keith L Ligon, Sanda Alexandrescu, W K Alfred Yung, Isabel Arrillaga-Romany, Johannes Gojo, Michelle Monje, Mats Nilsson, Mariella G Filbin. Nat Genet. 2022 Dec;54(12):1881-1894.
doi: 10.1038/s41588-022-01236-3. PMID: 36471067; PMCID: PMC9729116
Electrochemical DNA biosensor coupled to LAMP reaction for early diagnostics of cervical precancerous lesions. Ravery Sebuyoya, Ludmila Moráňová, Nasim Izadi, Roman Hrstka, Milan Anton, Martin Bartošík. Biosensors and Bioelectronics: X Volume 12, December 2022, 100224.
doi: 10.1016/j.biosx.2022.100224.
Electrochemical biosensors for analysis of DNA point mutations in cancer research. Kateřina Ondrášková, Ravery Sebuyoya, Ludmila Moráňová, Jitka Holčáková, Petr Voňka, Roman Hrstka, Martin Bartošík. Anal Bioanal Chem. 2023, Mar;415(6):1065-1085.
doi: 10.1007/s00216-022-04388-7 PMID: 36289102
Modulating the pharmacokinetic profile of Actinium-225-labeled macropa-derived radioconjugates by dual targeting of PSMA and albumin. Falco Reissig, Kristof Zarschler, Zbyněk Nový, Miloš Petřík, Kateřina Bendová, Daniela Kurfürstová, Jan Bouchal, Marie Charlotte Ludik, Florian Brandt, Klaus Kopka, Marta Khoylou, Hans-Jürgen Pietzsch, Marián Hajdúch, Constantin Mamat. Theranostics 2022, Oct 17;12(17):7203-7215.
doi: 10.7150/thno.78043. PMID: 36438496; PMCID: PMC9691366
Characterization of drug effects on cell cultures from phase-contrast microscopy images. Denis Baručić, Sumit Kaushik, Jan Kybic, Jarmila Stanková, Petr Džubák, Marián Hajdúch.
Comput Biol Med 2022, Dec;151(Pt A):106171
doi: 10.1016/j.compbiomed.2022.106171. PMID: 36306582
Chronic inflammation decreases HSC fitness by activating the druggable Jak/Stat3 signaling pathway. Srđan Grušanović, Petr Daněk, Maria Kuzmina, Miroslava Kari Adamcová, Burócziová, Monika, Romana Mikyšková, Karolina Vaníčková, Slađana Kosanović, Jana Pokorná, Milan Reiniš, Tomáš Brdička, Meritxell Alberich Jordà. EMBO Rep. 2023, Jan 9;24(1):e54729.
doi: 10.15252/embr.202254729. PMID: 36341527; PMCID: PMC9827550
γ-Tubulin in microtubule nucleation and beyond. Vadym Sulimenko, Eduarda Dráberová, Pavel Dráber. Front Cell Dev Biol. 2022, Sep 1;10:880761.
doi: 10.3389/fcell.2022.880761. PMID: 36158181; PMCID: PMC9503634
Discovery of small molecule mechanistic target of rapamycin inhibitors as anti-aging and anti-cancer therapeutics. Žofia Chrienová, David Ryšánek, Patrik Olekšák, Dorota Starý, Marek Bajda, Milan Reiniš, Romana Mikyšková, Ondřej Novotný, Rudolf Andrýs, Adam Skarka, Pavla Vašicová, Josef Novák, Martin Vališ, Kamil Kuča, Zdeněk Hodný, Eugenie Nepovimová. Front Aging Neurosci. 2022 Dec 6;14:1048260.
doi: 10.3389/fnagi.2022.1048260. PMID: 36561137; PMCID: PMC9767416
Involvement of Small Non-Coding RNA and Cell Antigens in Pathogenesis of Extramedullary Multiple Myeloma. Monika Vlachová, Jana Gregorová, Petra Vychytilová-Faltejsková, Natalia Anna Gabło, Lenka Radová, Lenka Pospíšilová, Martina Almáši, Martin Štork, Zdenka Knechtová, Jiří Minařík, Tereza Popková, Tomáš Jelínek, Roman Hájek, Luděk Pour, Lucie Říhová, Sabina Ševčíková. Int J Mol Sci. 2022, Nov 25;23(23):14765.
doi: 10.3390/ijms232314765. PMID: 36499093; PMCID: PMC9741227
Unexpected Heterogeneity of Newly Diagnosed Multiple Myeloma Patients with Plasmacytomas. Martin Štork, Sabina Ševčíková, Tomáš Jelínek, Jiří Minařík, Jakub Radocha, Tomáš Pika, Lenka Pospíšilová, Ivan Špička, Jan Štraub, Petr Pavlíček, Alexandra Jungová, Zdeňka Knechtová, Viera Sandecká, Vladimír Maisnar, Roman Hájek, Luděk Pour.
Biomedicines 2022, 10(10), 2535.
doi: 10.3390/biomedicines10102535. PMID: 36289797; PMCID: PMC9599767
More Than 2% of Circulating Tumor Plasma Cells Defines Plasma Cell Leukemia–Like Multiple Myeloma. Tomáš Jelínek, Renata Bezděková, David Žihala, Tereza Ševčíková, Anjana Anilkumar Sithara, Lenka Pospíšlová, Sabina Ševčíková, Petra Poláčková, Martin Štork, Zdeňka Knechtová, Ondřej Venglář, Veronika Kapustová, Tereza Popková, Ludmila Muroňová, Zuzana Chyra, Matouš Hrdinka, Michal Šimíček, Juan-Jose Garcés, Noemi Puig, Maria-Teresa Cedena, Artur Jurczyszyn, Jorge J Castillo, Miroslav Penka, Jakub Radocha, María Victoria Mateos, Jesús San Miguel, Bruno Paiva, Luděk Pour, Lucie Říhová, Roman Hájek. J Clin Oncol. 2022, Oct 31;JCO2201226.
doi: 10.1200/JCO.22.01226. PMID: 36315921
Distinct p53 phosphorylation patterns in chroniclymphocytic leukemia patients are reflected in theactivation of circumjacent pathways upon DNA damage. Veronika Mančíková, Michaela Pešová, Šárka Pavlová, Robert Helma, Kristýna Zavácká, Václav Hejret, Petr Taus, Jakub Hynšt, Karla Plevová, Jitka Malčíková, Šarka Pospíšilová. Mol. Oncol. 2023, Jan;17(1):82-97.
doi: 10.1002/1878-0261.13337. PMID: 36334078; PMCID: PMC9812841
Thiosemicarbazones and selected tyrosine kinase inhibitors synergize in pediatric solid tumors: NDRG1 upregulation and impaired prosurvival signaling in neuroblastoma cells. Maria Krchniakova, Silvia Paukovčeková, Petr Chlapek, Jakub Neradil, Jan Škoda, Renata Veselská. Front Pharmacol. 2022 Sep 7;13:976955.
doi: 10.3389/fphar.2022.976955. PMID: 36160437; PMCID: PMC9490180
Disulfriam increases the efficiency of 5-fluorouracil in organotypic cultures of colorectal carcinoma. Michal Hendrych, Kamila Říhová, Barbora Adamová, Vojtěch Hradil, Marek Stiborek, Petr Vlček, Markéta Hermanová, Jana Vašíčková, Petr Beneš, Jan Šmarda, Viktor Kanický, Jan Preisler, Jarmila Navrátilová. Biomed Pharmacother 2022, Sep;153:113465.
doi: 10.1016/j.biopha.2022.113465. PMID: 36076577
SoluProtMutDB: A manually curated database of protein solubility changes upon mutations. Jan Velecký, Marie Hamšíková, Jan Šťourač, Miloš Musil, Jiří Damborský, David Bednář, Stanislav Mazurenko. Comput Struct Biotechnol J. 2022, Nov 9;20:6339-6347.
doi: 10.1016/j.csbj.2022.11.009. PMID: 36420168; PMCID: PMC9678803
Minimal residual disease in BCR: ABL1-positive acute lymphoblastic leukemia: different significance in typical ALL and in CML-like disease. Jan Zuna, Lenka Hovorková, Justina Krotká, Amelie Koehrmann, Michela Bardini, Lucie Winkowská, Eva Froňková, Julia Alten, Rolf Koehler, Cornelia Eckert, Lisa Brizzolara, Marie Trková, Jan Stuchlý, Martin Zimmermann, Paola De Lorenzo, Maria Grazia Valsecchi, Valentino Conter, Jan Starý, Martin Schrappe, Andrea Biondi, Jan Trka, Markéta Žaliová, Giovanni Cazzaniga, Gunnar Cario.
Leukemia volume 36, pages 2793–2801 (2022).
doi: 10.1038/s41375-022-01668-0. PMID: 35933523
Long Non-Coding RNA and microRNA Interplay in Colorectal Cancer and Their Effect on the Tumor Microenvironment. Marie Rajtmajerová, Andriy Trailin, Václav Liška, Kari Jussi Hemminki, Filip Ambrozkiewicz. Cancers 2022, 14(21), 5450.
doi: 10.3390/cancers14215450. PMID: 36358867; PMCID: PMC9655812
Activated Hepatic Stellate Cells in Hepatocellular Carcinoma: Their Role as a Potential Target for Future Therapies. Esraa Ali, Andriy Trailin, Filip Ambrozkiewicz, Václav Liška, Kari Jussi Hemminki. Int. J. Mol. Sci. 2022, 23(23), 15292.
doi: 10.3390/ijms232315292. PMID: 36499616; PMCID: PMC9741299
LACTB exerts tumor suppressor properties in ovarian cancer through regulation of Slug. Valentina Cutano, Jessica Marianne Ferreira Mendes, Sara Escudeiro-Lopes, Susana Machado, Judith Vinaixa Forner, Juan M Gonzales-Morena, Martin Převorovský, Viacheslav Zemlianski, Yuxiong Feng, Petra Králová Viziová, Andrea Hartmanová, Beáta Malčeková, Pavel Jakoubě, Sonia Iyer, Zuzana Kečkéšová. Life Sci Alliance. 2022 Nov 14;6(1):e202201510.
doi: 10.26508/lsa.202201510. PMID: 36375842; PMCID: PMC9664245
TROP2 Represents a Negative Prognostic Factor in Colorectal Adenocarcinoma and Its Expression Is Associated with Features of Epithelial–Mesenchymal Transition and Invasiveness. Jiří Švec, Monika Šťastná, Lucie Janečková, Dušan Hrčkulák, Martina Vojtěchová, Jakub Onhajzer, Vítězslav Kříž, Kateřina Galušková, Eva Šloncová, Jan Kubovčiak, Lucie Pfeiferová, Jan Hrudka, Radoslav Matěj, Petr Waldauf, Lukáš Havlůj, Michal Kolář, Vladimír Kořínek. Cancers (Basel) 2022, Aug 26;14(17):4137.
doi: 10.3390/cancers14174137. PMID: 36077674; PMCID: PMC9454662
FBXO38 Ubiquitin Ligase Controls Centromere Integrity via ZXDA/B Stability. Nikol Dibus, Vladimír Kořínek, Lukáš Čermák. Front Cell Dev Biol. 2022 Jun 23;10:929288.
doi: 10.3389/fcell.2022.929288. PMID: 35813202; PMCID: PMC9260856
NGS better discriminates true MRD positivity for the risk stratification of childhood ALL treated on MRD-based protocol. Michael Svatoň, Aneta Skotnicová, Leona Řezníčková, Andrea Rennerová, Taťána Valová, Michaela Kotrová, Vincent H J van der Velden, Monika Brüggemann, Nikos Darzentas, Anton W Langerak, Jan Zuna, Jan Starý, Jan Trka, Eva Froňková. Blood (2023) 141 (5): 529–533.
doi: 10.1182/blood.2022017003. PMID: 36240445
Azulene hydrazide-hydrazones for selective targeting of pancreatic cancer cells. Tereza Brogyányi, Robert Kaplánek, Zdeněk Kejík, Božena Hosnedlová, Veronika Antonyová, Nikita Abramenko, Kateřina Veselá, Pavel Martásek, Martin Vokurka, Des R Richardson, Milan Jakubek. Biomedicine & Pharmacotherapy, 2022 Nov; 155:113736.
doi: 10.1016/j.biopha.2022.113736. PMID: 36156366
Restored biosynthetic pathways induced by MSCs serve as rescue mechanism in leukemia cells after L-asparaginase therapy. Natividad Alquezar-Artieda, Daniela Kužílková, Jennie Roberts, Katerina Hložková, Alena Pecinová, Petr Pecina, Martina Zwyrtková, Eliška Potůčková, Daniel Kavan, Ivana Hermanová, Markéta Žaliová, Petr Novák, Tomáš Mráček, Lucie Šrámková, Daniel A Tennant, Jan Trka, Júlia Starková. Blood Adv. 2022 Nov 18;bloodadvances.2021006431.
doi: 10.1182/bloodadvances.2021006431. PMID: 36399517
Pentamethinium salts suppress key metastatic processes by regulating mitochondrial function and inhibiting dihydroorotate dehydrogenase respiration. Jindriška Leischner Fialová, Kateřina Hönigová, Martina Raudenská, Lucie Mikšátková, Renata Zobalová, Jiří Navrátil, Jana Šmigová, Taraka Ramji Moturu, Tomáš Vicar, Jan Balvan, Kateřina Veselá, Nikita Abramenko, Zdeněk Kejík, Robert Kaplánek, Jaromír Gumulec, Daniel Rosel, Pavel Martásek, Jan Brábek. Jiří Neužil, Michal Masařík. Biomedicine & Pharmacotherapy, 2022 Oct; 154:113582.
doi: 10.1016/j.biopha.2022.113582. PMID: 36055111
Complex genetic and histopathological study of 15 patient-derived xenografts of aggressive lymphomas. Radek Jakša, Jana Karolová, Michael Svatoň, Dmitry Kazantsev, Martina Grajciarová, Eva Pokorná, Zbyněk Tonar, Magdalena Klánová, Lucie Winkowska, Diana Maláriková, Petra Vočková, Kristina Forsterová, Nicol Renešová, Alexandra Dolníková, Kristýna Nožičková, Pavel Dundr, Eva Froňková, Marek Trněný, Pavel Klener. Laboratory Investigation, 2022 Sep; 102(9):957-965.
doi: 10.1038/s41374-022-00784-w. PMID: 35488033; PMCID: PMC9420679
Non-Psychotropic Cannabinoids as Inhibitors of TET1 Protein. Veronika Antonyová, Zdeněk Kejík, Tereza Brogyanyi, Robert Kaplánek, Kateřina Veselá, Nikita Abramenko, Tomáš Ocelka, Michal Masařík, Adam Matkowski, Jakub Gburek, Renata Abel, Andrean Goede, Robert Preissner, Petr Novotný, Milan Jakubek. Bioorganic Chemistry, 2022 Jul; 124:105793.
doi: 10.1016/j.bioorg.2022.105793. PMID: 35462234
Targeting of the Mitochondrial TET1 Protein by Pyrrolo[3,2-b]pyrrole Chelators. Veronika Antonyová, Ameneh Tatar, Tereza Brogyányi, Zdeněk Kejík, Robert Kaplánek, Fréderic Vellieux, Nikita Abramenko, Alla Sinica, Jan Hajduch, Petr Novotný, Bettie Sue Masters, Pavel Martásek, Milan Jakubek. Int. J. Mol. Sci, 2022 Sep; 16;23(18):10850.
doi: 10.3390/ijms231810850. PMID: 36142763; PMCID: PMC9505425
G-CSF plus azacitidine versus azacitidine alone for patients with high-risk myelodysplastic syndrome: academic, open label, randomized trial. Tomáš Stopka, Lubomír Minařík, Nina Dusílková, Michal Pešta, Vojtěch Kulvait, Martin Špaček, Zuzana Zemanová, Marta Kalousová, Anna Jonášová. Blood Cancer Journal, volume 12, article number: 105 (2022).
doi: 10.1038/s41408-022-00698-2. PMID: 35798720; PMCID: PMC9262924
Combined Approach to Leukemic Differentiation Using Transcription Factor PU.1-Enhancing Agents. Petra Bašová, Helena Paszeková, Lubomír Minařík, Martina Dluhošová, Pavel Burda, Tomáš Stopka. Int. J. Mol. Sci, 2022, Jun; 16;23(12):6729.
doi: 10.3390/ijms23126729. PMID: 35743167; PMCID: PMC9224232
Quaternized Chitosan/Heparin Polyelectrolyte Multilayer Films for Protein Delivery. Tomasz Urbaniak, Gabriela S. García-Briones, Alexander Zhigunov, Sviatoslav Hladysh, Edyta Adrian, Volodymyr Lobaz, Tereza Krunclová, Olga Janoušková, Ognen Pop-Georgievski, Dana Kubies. Biomacromolecules 2022, 23, 11, 4734–4748.
doi: doi.org/10.1021/acs.biomac.2c00926. PMID: 36289568; PMCID: PMC9667497
New-Generation Heterocyclic Bis-Pentamethinium Salts as Potential Cytostatic Drugs with Dual IL-6R and Mitochondria-Targeting Activity. Veronika Talianová, Zdeněk Kejík, Robert Kaplánek, Kateřina Veselá, Nikita Abramenko, Lukáš Lacina, Karolína Strnadová, Barbora Dvořánková, Pavel Martásek, Michal Masařík, Magdalena Houdová Megová, Petr Bušek, Jana Křížová, Lucie Zdražilová, Hana Hansíková, Erik Vlčák, Vlada Filimonenko, Aleksi Šedo, Karel Smetana Jr, Milan Jakubek. Pharmaceutics 2022, 14(8), 1712.
doi: 10.3390/pharmaceutics14081712. PMID: 36015338
Biomarker Dynamics and Long-Term Treatment Outcomes in Breast Cancer Patients with Residual Cancer Burden after Neoadjuvant Therapy. Milos Holanek, Iveta Selingerova, Pavel Fabian, Oldrich Coufal, Ondrej Zapletal, Katarina Petrakova, Tomas Kazda, Roman Hrstka, Alexandr Poprach, Maria Zvarikova, Ondrej Bilek, Marek Svoboda. Diagnostics 2022, 12(7), 1740.
doi: 10.3390/diagnostics12071740. PMID: 35885644; PMCID: PMC9318288
Design, Synthesis, and Biochemical and Biological Evaluation of Novel 7-Deazapurine Cyclic Dinucleotide Analogues as STING Receptor Agonists. Zdeněk Vavřina, Pavla Perlíková, Nemanja Milisavljević, Florian Chevrier, Miroslav Smola, Joshua Smith, Milan Dejmek, Vojtěch Havlíček, Miloš Buděšínský, Radek Liboska, Lenka Vaneková, Jiří Brynda, Evzen Boura, Pavlína Řezáčová, Michal Hocek, and Gabriel Birkuš. J. Med. Chem.2022, 65, 20, 14082–14103.
doi: 10.1021/acs.jmedchem.2c01305. PMID: 36201304
Emetine blocks DNA replication via proteosynthesis inhibition not by targeting Okazaki fragments. David Lukac, Zuzana Machacova, Pavel Moudry. Life Sci Alliance. 2022 Sep 9;5(12):e202201560.
doi: 10.26508/lsa.202201560. PMID: 36260751; PMCID: PMC9463495
Synthesis of Polycyclic Hetero-Fused 7-Deazapurine Heterocycles and Nucleosides through C-H Dibenzothiophenation and Negishi Coupling. Chao Yang, Lenka Poštová Slavětínská, Marianne Fleuti, Blanka Klepetářová, Michal Tichý, Soňa Gurská, Petr Pavliš, Petr Džubák, Marián Hajdúch, Michal Hocek. J. Am. Chem. Soc. 2022, 144, 42, 19437–19446.
doi: 10.1021/jacs.2c07517. PMID: 36245092
Preparation, In Vitro Affinity, and In Vivo Biodistribution of Receptor-Specific Ga-Labeled Peptides Targeting Vascular Endothelial Growth Factor Receptors. Pavel Barta, Rajamanikkam Kamaraj, Monika Kucharova, Zbynek Novy, Milos Petrik, Katerina Bendova, Marian Hajduch, Petr Pavek, Frantisek Trejtnar. Bioconjugate Chem. 2022, 33, 10, 1825–1836.
doi: 10.1021/acs.bioconjchem.2c00272. PMID: 36197842
Modulation of FLT3-ITD and CDK9 in acute myeloid leukaemia cells by novel proteolysis targeting chimera (PROTAC). Eva Řezníčková, Soňa Krajčovičová, Miroslav Peřina, Markéta Kovalová, Miroslav Soural, Vladimír Kryštof. Europen Journal of Medicinal Chem. 2022, 243, 114792.
doi: 10.1016/j.ejmech.2022.114792. PMID: 36191408
Triterpenoid pyrazines and pyridines – Synthesis, cytotoxicity, mechanism of action, preparation of prodrugs. Jiří Hodoň, Ivo Frydrych, Zdeňka Trhlíková, Jan Pokorný, Lucie Borková, Sandra Benická, Martin Vlk, Barbora Lišková, Agáta Kubíčková, Martina Medvedíková, Martin Pisár, Jan Šarek, Viswanath Das, Anna Ligasová, Karel Koberna, Petr Džubák, Marián Hajdúch, Milan Urban. Europen Journal of Medicinal Chem. 2022, 243,114777.
doi: 10.1016/j.ejmech.2022.114777. PMID: 36174412
Mixture Effects of Tryptophan Intestinal Microbial Metabolites on Aryl Hydrocarbon Receptor Activity Aneta Vrzalová, Petra Pečinková, Peter Illés, Soňa Gurská, Petr Džubák, Martin Szotkowski, Marián Hajdúch, Sridhar Mani, Zdeněk Dvořák.
Int. J. Mol. Sci. 2022, 23 (18), 10825.
doi: 10.3390/ijms231810825. PMID: 36142735; PMCID: PMC9505659