Ondřej Slabý

Translational Cancer Genomics

Discovering genetic pathways to recovery!

  • Mission: Conduct translational genomics research that advances our knowledge and transforms the lives of cancer patients.
  • Vision: Understand how cancer genomes control carcinogenesis and response to cancer therapy, and use this knowledge to benefit patients.

Non-coding RNAs (ncRNAs) have significantly expanded the concept of molecular pathogenesis of cancer and have shown great potential to serve as diagnostic tools and therapeutic targets. In the last two decades, hundreds of individual ncRNAs of different classes have been shown to act as tumor suppressors or oncogenes in a wide range of cancers. However, we still lack a synthesis of this knowledge using systems biology approaches to define ncRNA deregulation as a novel hallmark of cancer.

SELECTED PUBLICATIONS
  • Vychytilova-Faltejskova P, Radova L, Sachlova M, Kosarova Z, Slaba K, Fabian P, Grolich T, Prochazka V, Kala Z, Svoboda M, Kiss I, Vyzula R, Slaby O. Serum-Based MicroRNA Signatures in Early Diagnosis and Prognosis Prediction of Colon Cancer. Carcinogenesis. 2016;37(10):941-950. DOI: 10.1093/carcin/bgw078
  • Vychytilova-Faltejskova P, Merhautova J, Machackova T, Gutierrez-Garcia I, Garcia-Solano J, Radova L, Brchnelova D, Slaba K, Svoboda M, Halamkova J, Demlova R, Kiss I, Vyzula R, Conesa-Zamora P, Slaby O. MiR-215-5p is a tumor suppressor in colorectal cancer targeting EGFR ligand epiregulin and its transcriptional inducer HOXB9. Oncogenesis. 2017;6(11):399. DOI: 10.1038/s41389-017-0006-6
  • Chen B, Dragomir MP, Fabris L, Bayraktar R, Knutsen E, Liu X, Tang C, Li Y, Shimura T, Ivkovic TC, De Los Santos MC, Anfossi S, Shimizu M, Shah MY, Ling H, Shen P, Multani AS, Pardini B, Burks JK, Katayama H, Reineke LC, Huo L, Syed M, Song S, Ferracin M, Oki E, Fromm B, Ivan C, Bhuvaneshwar K, Gusev Y, Mimori K, Menter D, Sen S, Matsuyama T, Uetake H, Vasilescu C, Kopetz S, Parker-Thornburg J, Taguchi A, Hanash SM, Girnita L, Slaby O, Goel A, Varani G, Gagea M, Li C, Ajani JA, Calin GA. The Long Noncoding RNA CCAT2 Induces Chromosomal Instability Through BOP1-AURKB Signaling. Gastroenterology. 2020;159(6):2146-2162.e33. DOI: 10.1053/j.gastro.2020.08.018
  • Liu I, Jiang L, Samuelsson ER, Marco Salas S, Beck A, Hack OA, Jeong D, Shaw ML, Englinger B, LaBelle J, Mire HM, Madlener S, Mayr L, Quezada MA, Trissal M, Panditharatna E, Ernst KJ, Vogelzang J, Gatesman TA, Halbert ME, Palova H, Pokorna P, Sterba J, Slaby O, Geyeregger R, Diaz A, Findlay IJ, Dun MD, Resnick A, Suvà ML, Jones DTW, Agnihotri S, Svedlund J, Koschmann C, Haberler C, Czech T, Slavc I, Cotter JA, Ligon KL, Alexandrescu S, Yung WKA, Arrillaga-Romany I, Gojo J, Monje M, Nilsson M, Filbin MG. The landscape of tumor cell states and spatial organization in H3-K27M mutant diffuse midline glioma across age and location. Nat Genet. 2022;54(12):1881-1894. DOI: 10.1038/s41588-022-01236-3
  • Palova H, Das A, Pokorna P, Bajciova V, Pavelka Z, Jezova M, Pal K, Dimayacyac JR, Negm L, Stengs L, Bianchi V, Vejmelkova K, Noskova K, Jarosova M, Mejstrikova S, Mudry P, Kyr M, Merta T, Tinka P, Drabova K, Aulicka S, Jugas R, Tabori U, Slaby O, Sterba J. Precision immuno-oncology approach for four malignant tumors in siblings with constitutional mismatch repair deficiency syndrome. NPJ Precis Oncol. 2024;8(1):110. DOI: 10.1038/s41698-024-00597-8
SPECIALIZED EXPERTISE AND TECHNOLOGY

Cancer genomics (whole genome, whole exome sequencing, RNA sequencing, small RNA sequencing)

Functional genomics and genome modifications (CRISPR/Cas9)

Processing of challenging biological material for genomic analyses (liquid biopsy, FFPE tissue samples)

COLLABORATION WITH LARGE RESEARCH INFRASTRUCTURES AND RESEARCH CENTRES

Czech Clinical Research Infrastructure Research CZECRIN

National infrastructure for translational medicine EATRIS-CZ

National Center for Medical Genomics NCMG