Under the auspices of NICR, the Institute of Biochemistry and Experimental Oncology, First Faculty of Medicine, Charles University hosted a lecture by Jakub Cibulka from the Laboratory of Recombination and DNA Repair (Lumír Krejčí Group, Masaryk University).
Invited by Martin Sztacho from the Laboratory of Cancer Cell Architecture at the Institute of Biochemistry and Experimental Oncology, Charles University, and NICR, Jakub Cibulka presented recent advances in understanding how biomolecular condensates contribute to the maintenance of genome integrity. He demonstrated how in vitro reconstitution systems provide powerful tools for dissecting the molecular principles governing phase separation during DNA damage repair, allowing researchers to reconstruct complex biological processes from purified components. He also highlighted how condensate formation coordinates DNA repair pathways and how disruption of these mechanisms contributes to cancer development.
"Dr. Cibulka's visit provided an excellent opportunity for scientific discussions with researchers and students at our institute, particularly in view of our laboratory's ongoing research into biomolecular condensates in cancer, nuclear organization, and transcriptional regulation. The seminar stimulated lively discussions on emerging experimental approaches to studying phase separation and their implications for genome stability and oncogenesis," said Martin Sztacho.
The seminar was part of a lecture series organized under the auspices of the National Institute for Cancer Research, showcasing current advances in biomedical research and providing a platform for scientific discussion among researchers and students.
