Michal Kroupa

Biomarkers of early cancer detection, patient prognosis, and treatment response

Head: Michal Kroupa
Prague node

michal.kroupa@iem.cas.cz
website of the Institute

HOME INSTITUTION

Institute of Experimental Medicine of the Czech Academy of Sciences

RESEARCH PROGRAMME(S)

RP 1 - Molecular basis of cancer and molecular targets
RP 3 - Biomarkers of cancers and cancer diagnostics

An investment in cancer research is an investment in the future!

Mission: To employ molecular profiling of gastrointestinal cancers to elucidate variations in therapeutic response, patient survival, and cancer susceptibility.
Vision: To improve patient outcomes by turning advanced molecular research into tools for early detection, prognosis, and personalized treatment.

A central focus of our research is gastrointestinal cancers, with an emphasis on identifying biomarkers for early detection, prognostic stratification, and prediction of treatment response. Through close collaboration with clinicians, we access a wide range of patient-derived biological materials, including tumor biopsies and body fluids, which we analyze using advanced technologies such as multi-omics approaches. This integrative, technology-driven strategy has the potential to translate molecular insights into meaningful advances in precision oncology.

SELECTED PUBLICATIONS

Kroupa M, Kubecek O, Tomasova K, Hanak P, Krupova M, Cervena K, Siskova A, Rosendorf J, Hosek P, Vodickova L, Vodicka P, Liska V, John S, Vymetalkova V, Petera J. The dynamics of telomere length in primary and metastatic colorectal cancer lesions. Sci Rep. 2023 Jun 5;13(1):9097. DOI: 10.1038/s41598-023-35835-9
Tomasova, K., Seborova, K., Kroupa, M., Horak, J., Kavec, M., Vodickova, L., Rob, L., Hruda, M., Mrhalova, M., Bartakova, A., Bouda, J., Fleischer, T., Kristensen, V. N., Vodicka, P., & Vaclavikova, R. (2024). Telomere length as a predictor of therapy response and survival in patients diagnosed with ovarian carcinoma. Heliyon, 10(13), e33525. DOI: 10.1016/j.heliyon.2024.e33525
Kroupa M, Rachakonda SK, Liska V, Srinivas N, Urbanova M, Jiraskova K, Schneiderova M, Vycital O, Vymetalkova V, Vodickova L, Kumar R, Vodicka P. Relationship of telomere length in colorectal cancer patients with cancer phenotype and patient prognosis. Br J Cancer. 2019 Aug;121(4):344-350. Epub 2019 Jul 17. DOI: 10.1038/s41416-019-0525-3
Tomasova K, Kroupa M, Zinkova A, Korabecna M, Vymetalkova V, Skrobanek P, Sojka L, Levy M, Hemminki K, Liska V, Hosek P, Kumar R, Vodickova L, Vodicka P. Monitoring of telomere dynamics in peripheral blood leukocytes in relation to colorectal cancer patients’ outcomes. Front Oncol. 2022 Sep 20;12:962929. DOI: 10.3389/fonc.2022.962929
Kroupa M, Rachakonda S, Vymetalkova V, Tomasova K, Liska V, Vodenkova S, Cumova A, Rossnerova A, Vodickova L, Hemminki K, Soucek P, Kumar R, Vodicka P. Telomere length in peripheral blood lymphocytes related to genetic variation in telomerase, prognosis and clinicopathological features in breast cancer patients. Mutagenesis. 2020 Dec 31;35(6):491-497. DOI: 10.1093/mutage/geaa030