How has our understanding of T-lymphocyte development and T-cell receptor signaling evolved over the past two decades? And what do these advances mean for contemporary immunology and the future of targeted therapies? These and other questions will be addressed by leading molecular immunologist Jonathan S. Duke-Cohan.
As part of the Biomedical Research News lecture series, designed for Ph.D. students and the broader scientific community, Jonathan S. Duke-Cohan will deliver a lecture entitled “Reassessing the Controls on Thymocyte Development 20 Years On” on Thursday, March 12, 2026, at 3:00 p.m. The event will take place in the Cori Lecture Hall at the First Faculty of Medicine, Charles University (U Nemocnice 5, Prague 2).
Jonathan S. Duke-Cohan serves as Principal Associate in Medicine at Harvard Medical School, Principal Research Scientist at Dana-Farber Cancer Institute, and Visiting Professor at the First Faculty of Medicine, Charles University. His research focuses on protein interactions which lead to the development, maturation, differentiation, and activation of T lymphocytes in both health and disease.
The lecture will offer a critical perspective on two decades of research into the molecular and cellular mechanisms regulating thymocyte development. It will examine how advances in molecular signaling, studies of the thymic microenvironment, and systems immunology have refined our understanding of T-cell selection, lineage commitment, and functional responses. Particular emphasis will be placed on the evolving view of T-cell receptor (TCR) signaling mechanisms—an area central to understanding immunopathology and to advancing modern immunotherapeutic approaches.
We look forward to welcoming you!
